IkB-alpha Products

IkB-alpha Antibody
IkB-alpha Antibody
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
IkB-alpha Knockout 293T Cell ...
IkB-alpha Knockout 293T Cell Lysate
Species: Hu
Applications: WB
IkB-alpha Overexpression Lysa ...
IkB-alpha Overexpression Lysate
Species: Hu
Applications: WB
IkB-alpha Recombinant Protein ...
IkB-alpha Recombinant Protein Antigen
Species: Hu
Applications: AC
Recombinant Human IkB-alpha P ...
Recombinant Human IkB-alpha Protein
Species: Hu
Applications: PAGE


NF-kB is silenced in the cytoplasm by an inhibitory protein, IkB (1). Synthesis of IkBa is autoregulated (2). IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g (3-6). External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Six members of IkB family members have been identified (1). One of the first gene induced following NF-kB activation is IkBa.


Entrez Human
Uniprot Human
Product By Gene ID 4792
Alternate Names
  • MAD3
  • I-kappa-B-alpha
  • IkB-alpha
  • Major histocompatibility complex enhancer-binding protein MAD3
  • nuclear factor of kappa light chain gene enhancer in B-cells
  • MAD-3
  • IkappaBalphaNF-kappa-B inhibitor alpha
  • IKBAikB-alpha
  • alpha
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor

Research Areas for IkB-alpha

Find related products by research area and learn more about each of the different research areas below.

Cell Biology
Diabetes Research
DNA Repair
Nucleotide Excision Repair
Signal Transduction

PTMs for IkB-alpha

Learn more about PTMs related to IkB-alpha.


Bioinformatics Tool for IkB-alpha

Discover related pathways, diseases and genes to IkB-alpha. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Vizit™, under license from BioVista Inc.

Related IkB-alpha Blog Posts

Check out the latest blog posts on IkB-alpha.
Sample collection from mammalian culture cells for kinomic analysis
By Jamshed Arslan Pharm.D., PhD.IntroductionKinome describes kinases, and kinomics refers to the kinase signaling. Studying the effects of reagent (exogenously applied growth factor or inhibitor) on kinase activit...    Read more.
The effects of curcumin on IKB Alpha and the NFkB signaling pathway
The IKK complex, or inhibitor of NFkB kinase, is composed of IKK alpha and IKK beta.  These kinases are at the core of the NFkB signaling cascade.  The NFkB family is made up of transcription factors that are kept inactive in the cytoplasm through...    Read more.
Inhibitor kappa B-alpha (IkappaB-alpha)
The transcription factor nuclear factor kappa beta (NFkB) is highly regulated by triggers such as stress, free-radicals, UV light, and hypoxia. NFkB is one of the fastest responding transcription factors in humans. The NFKB signaling pathway is ess...    Read more.
Read more IkB-alpha related blogs.