IkB-alpha Products

Antibodies
IkB-alpha Antibody
IkB-alpha Antibody
NBP1-87761
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P, IP
Host: Rabbit Polyclonal
Lysates
IkB-alpha Overexpression Lysa ...
IkB-alpha Overexpression Lysate (N...
NBP2-06636
Applications: WB
Proteins
IkB-alpha Recombinant Protein ...
IkB-alpha Recombinant Protein
H00004792-P01
Species: Hu
Applications: WB, ELISA, PA
IkB-alpha Recombinant Protein ...
IkB-alpha Recombinant Protein Antigen
NBP1-87761PEP
Species: Hu
Applications: AC
IkB-alpha Recombinant Protein ...
IkB-alpha Recombinant Protein
NBP1-72500
Species: Hu
Applications: PAGE
RNAi

Description

NF-kB is silenced in the cytoplasm by an inhibitory protein, IkB (1). Synthesis of IkBa is autoregulated (2). IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g (3-6). External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Six members of IkB family members have been identified (1). One of the first gene induced following NF-kB activation is IkBa.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Product By Gene ID 4792
Alternate Names
  • MAD3
  • I-kappa-B-alpha
  • IkB-alpha
  • Major histocompatibility complex enhancer-binding protein MAD3
  • nuclear factor of kappa light chain gene enhancer in B-cells
  • MAD-3
  • IkappaBalphaNF-kappa-B inhibitor alpha
  • IKBAikB-alpha
  • NFKBI
  • alpha
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor

Research Areas for IkB-alpha

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cell Biology
Diabetes Research
DNA Repair
Nucleotide Excision Repair
Phospho-Specific
Signal Transduction

PTMs for IkB-alpha

Learn more about PTMs related to IkB-alpha.

Phosphorylation
Biotinylation
Acetylation
Methylation

Bioinformatics Tool for IkB-alpha

Discover related pathways, diseases and genes to IkB-alpha. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related IkB-alpha Blog Posts

Check out the latest blog posts on IkB-alpha.
Inhibitor kappa B-alpha (IkappaB-alpha)
The transcription factor nuclear factor kappa beta (NFkB) is highly regulated by triggers such as stress, free-radicals, UV light, and hypoxia. NFkB is one of the fastest responding transcription factors in humans. The NFKB signaling pathway is ess...    Read more.
Read more IkB-alpha related blogs.