IFITM3/Fragilis Antibody [Biotin]

• Reactivity: Mu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Biotin
• Concentration: LYOPH

IFITM3/Fragilis Antibody [Biotin] Summary

• Immunogen: E. coli-derived recombinant mouse IFITM3/Fragilis
  Asn2-His57
  Accession # NP_079654
• Specificity: Detects mouse IFITM3/Fragilis in Western blots. In Western blots, approximately 50% cross-reactivity with recombinant human IFITM3 is observed.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: IFITM3
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot 0.1 ug/mL
• Readout System:
  • Streptavidin Native Protein NBP2-29367
  • Streptavidin Native Protein NBP2-29370
  • Streptavidin Native Protein NBP2-29371

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IFITM3/Fragilis Antibody [Biotin]

• 1-8U
• Fragilis
• IFITM3
• interferon induced transmembrane protein 3 (1-8U)
• interferon-induced transmembrane protein 3
• Interferon-inducible protein 1-8U
• IP15
• mil-1

Background

Mouse IFITM3 (also Fragilis) is a 137 amino acids (aa) 2-transmembrane protein that belongs to the Fragilis family of interferon-inducible genes. It contains two terminal extracellular domains (aa's 1-57 and 131-137) and one cytoplasmic region that potentially allows for multiple phosphorylations. The N-terminal extracellular region of mouse IFITM3 is 54%, 91% and 58% aa identical to the equivalent region in bovine, rat and human IFITM3, respectively. IFITM3 seems to be involved in primordial germ cell clustering and regionalization.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for IFITM3/Fragilis Antibody (BAF3377)(1)

Publication using BAF3377

• Schmidt, A;Fuchs, J;Dedden, M;Kocher, K;Schülein, C;Hübner, J;Vieira Antão, A;Irrgang, P;Oltmanns, F;Viherlehto, V;Leicht, N;Rieker, RJ;Geppert, C;Appelt, U;Zundler, S;Schober, K;Lapuente, D;Tenbusch, M; Inflammatory conditions shape phenotypic and functional characteristics of lung-resident memory T cells in mice Nature communications 2025-04-16 [PMID: 40240341] (Flow Cytometry, Mouse)

Bioinformatics

• Gene Symbol: IFITM3
• Uniprot:
  • NP_079654()