Viperin Antibody

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Western Blot: Viperin Antibody [NBP2-03971] - analysis of viperin using viperin polyclonal antibody. Human brain lysate in the absence (1) and presence (2) of immunizing peptide, mouse brain (3) and rat brain (4) lysate ...read more
Immunohistochemistry-Paraffin: Viperin Antibody [NBP2-03971] - Analysis of viperin using viperin polyclonal antibody. Human rectum tissue probed with viperin antibody at 5 ug/ml.

Product Details

Summary
Reactivity Hu, Mu, Rt, Po, Bv, Ca, Ch, ChHa, Eq, Pm, RbSpecies Glossary
Applications WB, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

Viperin Antibody Summary

Immunogen
A portion of amino acids 165-215 of human viperin was used as the immunogen for this antibody.
Specificity
The amino acid sequence used as immunogen is 100% homologous in human, mouse, rat, white-cheeked gibbon, chinese hamster, rhesus monkey, common chimpanzee, pig, new world monkey, panda, african bush elephant and orangutan, 95% in horse, wild turkey, opossum, platypus, 89% in western clawed frog, rabbit, zebra finch, chicken, 79% in carolina anole, and 63% homologous in zebrafish and sablefish.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
RSAD2
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Western Blot 3-5 ug/ml
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 5ug/ml

Reactivity Notes

Cross reacts with Chimpanzee, Chinese Hamster, Orangutan. Predicted to react with Zebrafish.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
0.2 ml PBS and 0.05% BSA
Preservative
0.05% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein A purified

Alternate Names for Viperin Antibody

  • 2510004L01Rik
  • cig33
  • cig5
  • Cytomegalovirus-induced gene 5 protein
  • interferon-inducible
  • radical S-adenosyl methionine domain containing 2
  • radical S-adenosyl methionine domain-containing protein 2
  • vig1
  • viperin
  • Virus inhibitory protein, endoplasmic reticulum-associated

Background

Viperin is a 43kDa protein which is one of several hundred interferon inducible viral proteins. Elevated expression of viperin is induced by LPS and poly I:C through TLR dependent signaling pathways. Sendai virus mediated viperin expression is induced independently of TLR signaling pathways through RLRs - RIG-I and MAVs (Severa, 2006). Viperin has been shown to play an important role in interferon mediated anti-viral activity in a Hepatitis C virus model system (Helbig, 2011). Viperin is induced in lymphoid cells and dendritic cells (DCs) and highly induced in neutrophils and macrophages during acute LCMV infection in mice (Hinson, ). Viperin functions as a mediator of viral resistance and as a marker for interferon responsiveness making its detection and mechanism of action through specific antibody probes valuable for further studies. Additionally, viperin antibodies provide useful information for analysis of specific cell types responsive to interferon making it valuable for phenotyping studies complementing mechanism of action analysis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Blogs on Viperin.

Viperin: A Cellular Inhibitor of DNA and RNA Viruses
Viperin (Virus Inhibitory Protein, Endoplasmic Reticulum-associated, Interferon-inducible) inhibits the replication of a broad spectrum of viruses by several diverse mechanisms. The protein was first identified in 2001, when it was found to be the pro...  Read full blog post.

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Bioinformatics

Gene Symbol RSAD2
Uniprot