Humanin Antibody

Western Blot: Humanin Antibody [NB100-56877] - Analysis of Humanin in (A) recombinant fusion protein containing amino acids 1-24 and (B) fusion partner without these amino acids, using Humanin antibody at 1:2000.

Immunohistochemistry-Paraffin: Humanin Antibody [NB100-56877] - Analysis Humanin in human testis at 1:100.

• Reactivity: Hu
• Applications: WB, ELISA, ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated

Humanin Antibody Summary

• Immunogen: The full length peptide sequence from the human MT-RNR2 protein (accesion number Q8IVG9).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: MTRNR2L1
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:1000
  • Immunocytochemistry/Immunofluorescence reported by customer review
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:100
  • Western Blot 1:500-1:2000

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Whole antisera with 50% Glycerol
• Preservative: 0.025% Sodium Azide
• Purity: Unpurified

Alternate Names for Humanin Antibody

• HN
• HUNIN

Background

Humanin is a novel 24 A.A polypeptide identified in Alzheimer's disease-affected brain. It is 99% homologous to mitochondrial 16s ribosomal RNA and functions as a novel neuroprotective and cytoprotective factor. It specifically inhibits neuronal cell death induced by beta-amyloids and Alzheimer's disease causing FAD genes by competitively inhibiting access of FPRL1 receptor to beta-amyloids. It acts as an anti-apoptotic factor by binding to Bcl-2/Bax family of pro-apoptotic factors including Bax, Bak, Bid and BimEL and inhibits their pro-apoptotic activity. It activates JAK/STAT signaling pathway and is regulated by TRIM11. It interacts with IGFBP-3 and specifically blocks IGFBP-3 induced cell death in glioblastoma cells. Humanin is also expressed in colon and testis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Humanin Antibody (NB100-56877)(1)

Publication using NB100-56877

• Celvin B Prevention of growth failure caused by glucocorticoids and inflammation Thesis

Review for Humanin Antibody (NB100-56877) (1)

Average Rating: 3

(Based on 1 review)

We have 1 review tested in 1 species: Human.

reviewed by: Verified Customer IF Human 05/02/2014

Summary

• Application: Immunofluorescence
• Sample Tested: cells
• Species: Human
• Lot: CS032105A-02

Bioinformatics

• Gene Symbol: MTRNR2L1
• Uniprot:
  • Q8IVG9(Human)