Humanin Antibody - BSA Free

Western Blot: Humanin Antibody [NB100-56877] - Analysis of Humanin in (A) recombinant fusion protein containing amino acids 1-24 and (B) fusion partner without these amino acids, using Humanin antibody at 1:2000.

Immunohistochemistry-Paraffin: Humanin Antibody [NB100-56877] - Analysis Humanin in human testis at 1:100.

• Reactivity: Hu
• Applications: WB, ELISA, ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

Humanin Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit Humanin Antibody - BSA Free (NB100-56877) is a polyclonal antibody validated for use in IHC, WB, ELISA and ICC/IF. Anti-Humanin Antibody: Cited in 3 publications. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: The full length peptide sequence from the human MT-RNR2 protein (accesion number Q8IVG9).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: MTRNR2L1
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:1000
  • Immunocytochemistry/ Immunofluorescence reported by customer review
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:100
  • Western Blot 1:500-1:2000

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Whole antisera with 50% Glycerol
• Preservative: 0.025% Sodium Azide
• Purity: Unpurified

Alternate Names for Humanin Antibody - BSA Free

• HN
• HUNIN

Background

Humanin is a novel 24 A.A polypeptide identified in Alzheimer's disease-affected brain. It is 99% homologous to mitochondrial 16s ribosomal RNA and functions as a novel neuroprotective and cytoprotective factor. It specifically inhibits neuronal cell death induced by beta-amyloids and Alzheimer's disease causing FAD genes by competitively inhibiting access of FPRL1 receptor to beta-amyloids. It acts as an anti-apoptotic factor by binding to Bcl-2/Bax family of pro-apoptotic factors including Bax, Bak, Bid and BimEL and inhibits their pro-apoptotic activity. It activates JAK/STAT signaling pathway and is regulated by TRIM11. It interacts with IGFBP-3 and specifically blocks IGFBP-3 induced cell death in glioblastoma cells. Humanin is also expressed in colon and testis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Humanin Antibody (NB100-56877)(4)

Publications using NB100-56877

• Velentza L, Wickström M, Kogner P et Al. Humanin Treatment Protects Against Venetoclax-Induced Bone Growth Retardation in Ex Vivo Cultured Rat Bones J Endocr Soc 2024-01-16 [PMID: 38328478]
• Yunhan Zhao, Outi Mäkitie, Saila Laakso, Vera Fedosova, Lars Sävendahl, Farasat Zaman A novel link between chronic inflammation and humanin regulation in children Frontiers in Endocrinology 2024-01-23 [PMID: 38322155]
• Pe�a Agudelo JA, Pidre ML, Garcia Fallit M et al. Mitochondrial Peptide Humanin Facilitates Chemoresistance in Glioblastoma Cells Cancers (Basel) 2023-08-11 [PMID: 37627089] (Immunocytochemistry/ Immunofluorescence)
• Celvin B Prevention of growth failure caused by glucocorticoids and inflammation Thesis

Review for Humanin Antibody (NB100-56877) (1)

Average Rating: 3

(Based on 1 review)

We have 1 review tested in 1 species: Human.

reviewed by: Manjari Dimri IF Human 05/02/2014

Summary

• Application: Immunofluorescence
• Sample Tested: cells
• Species: Human
• Lot: CS032105A-02

Bioinformatics

• Gene Symbol: MTRNR2L1
• Uniprot:
  • Q8IVG9(Human)