Human Total PDGF R alpha DuoSet IC ELISA, 2 Plate Summary
No significant interference observed with available related molecules.
Packaging, Storage & Formulations
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Human Total PDGF R alpha DuoSet IC ELISA, 2 Plate
alpha-type platelet-derived growth factor receptor CD140 antigen-like family member A CD140a antigen CD140a EC 2.7.10 EC 18.104.22.168 MGC74795 PDGF R alpha PDGFR alpha PDGFR2 PDGFRA PDGFRA/BCR fusion PDGF-R-alpha platelet-derived growth factor receptor, alpha polypeptide rearranged-in-hypereosinophilia-platelet derived growth factor receptor alphafusion protein RHEPDGFRA Background
PDGF R alpha (Platelet-Derived Growth Factor Receptor alpha) is a transmembrane receptor tyrosine kinase that can form homodimers or heterodimers with PDGF R beta when engaged by dimers of the PDGF ligands. PDGF R alpha binds to PDGF-AA, PDGF-AB, and PDGF-CC. It is strongly expressed in oligodendrocyte, lung, skin, and intestinal progenitor cells, at low levels in most mesenchymal cells, and can be induced by inflammation. PDGF R alpha function is important during formation of the cranial and cardiac neural crest, retina, gonads, lung alveoli, intestinal villi, skin, hair follicles, skeleton, teeth, palate, and interstitial kidney mesenchyme. Dysregulated PDGF R alpha signaling can result in spina bifida or cleft palate-type malformations. Postnatally, PDGF R alpha is implicated in gliomas and fibrotic disorders of lung, heart, and skin (scleroderma).
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Publications for PDGFR alpha (DYC322-2)(1)
We have publications tested in 1 confirmed species: Human.
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Publication using DYC322-2
Aderhold C, Faber A, Grobschmidt G, Chakraborty A, Bockmayer A, Umbreit C, Birk R, Stern-Straeter J, Hormann K, Schultz J Small molecule-based chemotherapeutic approach in p16-positive and -negative HNSCC in vitro. Anticancer Res, 2013;33(12):5385-93. 2013 [PMID: 24324073] (Human)
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