TNF RI/TNFRSF1A Products

Description

The protein encoded by the TNF Receptor I gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. (provided by RefSeq)

Bioinformatics

Entrez	21937 Mouse 25625 Rat 7132 Human
Uniprot	AAA36756 Human AAH10140 Human ABW03527.1 Human NM_001065 Human NP_001056 Human NP_035739 Mouse P19438 Human P19438.1 Human
Product By Gene ID	7132
Alternate Names	CD120a antigen CD120a FPF p55 p55-R p60 TNFARMGC19588 TNF-R TNF-R1 TNFR1TBP1 TNFR55 TNF-R55 TNFR60 TNF-RI TNF-R-I TNFR-I tumor necrosis factor binding protein 1 Tumor necrosis factor receptor 1 tumor necrosis factor receptor 1A isoform beta tumor necrosis factor receptor superfamily member 1A tumor necrosis factor receptor superfamily, member 1A tumor necrosis factor receptor type 1 Tumor necrosis factor receptor type I tumor necrosis factor-alpha receptor

Research Areas for TNF RI/TNFRSF1A

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cytokine Research
Phospho-Specific