Human RAGE Quantikine ELISA Kit

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

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Catalog# & Conjugate Size Price

Human RAGE Quantikine ELISA Kit Summary

Background
The Quantikine Human RAGE Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human RAGE (extracellular domain) in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant human RAGE/Fc Chimera and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human RAGE showed linear curves that were parallel to the standa...rd curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring RAGE.
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Specificity
Natural and recombinant human RAGE
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
AGER

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DRG00.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human RAGE Quantikine ELISA Kit

  • advanced glycosylation end product-specific receptor
  • AGER
  • RAGE isoform delta
  • RAGE isoform sRAGE-delta
  • RAGE
  • Receptor for advanced glycosylation end products
  • receptor for advanced glycosylation end-products
  • SCARJ1

Background

RAGE (Receptor for Advanced Glycation End product) is a transmembrane glycoprotein that binds advanced glycation end products (AGEs), beta-amyloid peptides, HMGB1/Amphoterin, and several S100 family proteins. AGEs are adducts formed by the non-enzymatic glycation and oxidation of proteins and lipids. A soluble form can also be generated by MMP-mediated shedding. RAGE is expressed in the CNS during development as well as in adult endothelial cells, smooth muscle cells, pericytes, monocytes, and neurons. It is locally upregulated in vascular inflammation (e.g. diabetes, atherosclerosis, vascular injury, Alzheimer’s disease). At these sites, RAGE binding to S100A1, EN-RAGE/S100A12, or S100B induces inflammatory immune cell adhesion and infiltration as well as vascular smooth muscle proliferation, neointimal expansion, atherosclerotic plaque development, and transport of A-beta into the cerebrospinal fluid. In cancer, RAGE binding to HMGB1, S100A8, or S100A9 promotes tumor growth and metastasis in addition to inflammatory cell infiltration.

To view our complete solutions for RAGE research, visit bio-techne.com.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for AGER (DRG00)(76)

We have publications tested in 2 confirmed species: Human, Chinese Hamster.


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Human
(75)
Chinese Hamster
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Showing Publications 1 - 10 of 76. Show All 76 Publications.
Publications using DRG00 Applications Species
Elsadek, MF; Effectiveness of two photosensitizer-mediated photodynamic therapy for treating moderate peri-implant infections in type-II diabetes mellitus patients: A randomized clinical trial Photodiagnosis and photodynamic therapy 2023-06-01 [PMID: 37270045] (Human) Human
SJ Barnard, J Haunschild, L Heiser, MT Dieterlen, K Klaeske, MA Borger, CD Etz Apoptotic Cell Death in Bicuspid-Aortic-Valve-Associated Aortopathy International Journal of Molecular Sciences, 2023-04-18;24(8):. 2023-04-18 [PMID: 37108591] (Human) Human
Y Peng, F Liu, Y Qiao, P Wang, H Du, C Si, X Wang, K Chen, F Song Genetically Modified Circulating Levels of Advanced Glycation End-Products and Their Soluble Receptor (AGEs-RAGE Axis) with Risk and Mortality of Breast Cancer Cancers, 2022-12-12;14(24):. 2022-12-12 [PMID: 36551607] (Human) Human
L Butcher, JC Zaldua, JA Carnicero, K Hawkins, J Whitley, R Mothukuri, PA Evans, K Morris, S Pillai, JD Erusalimsk High levels of soluble RAGE are associated with a greater risk of mortality in COVID-19 patients treated with dexamethasone Respiratory Research, 2022-11-05;23(1):303. 2022-11-05 [PMID: 36335329] (Human) Human
S Reichert, B Hofmann, M Kohnert, AN Santos, L Friebe, J Grollmitz, HG Schaller, S Schulz Advanced Glycation End Product (AGE) and Soluble Receptor of AGE (sRAGE) Levels in Relation to Periodontitis Severity and as Putative 3-Year Outcome Predictors in Patients Undergoing Coronary Artery Bypass Grafting (CABG) Journal of Clinical Medicine, 2022-07-15;11(14):. 2022-07-15 [PMID: 35887868] (Human) Human
E Galliera, L Massaccesi, L Yu, J He, M Ranucci, MM Corsi Roma SCD14-ST and New Generation Inflammatory Biomarkers in the Prediction of COVID-19 Outcome Biomolecules, 2022-06-13;12(6):. 2022-06-13 [PMID: 35740951] (Human) Human
A Karas, D Holmannova, P Borsky, Z Fiala, C Andrys, K Hamakova, T Svadlakova, V Palicka, J Krejsek, V Rehacek, M Esterkova, H Kovarikova, L Borska Significantly Altered Serum Levels of NAD, AGE, RAGE, CRP, and Elastin as Potential Biomarkers of Psoriasis and Aging-A Case-Control Study Biomedicines, 2022-05-13;10(5):. 2022-05-13 [PMID: 35625870] (Human) Human
C Helou, MT Nogueira S, C Niquet-Ler, P Jacolot, E Boulanger, F Delguste, A Guilbaud, M Genin, PM Anton, C Delayre-Or, T Papazian, M Howsam, FJ Tessier Plasma Levels of Free N?-Carboxymethyllysine (CML) after Different Oral Doses of CML in Rats and after the Intake of Different Breakfasts in Humans: Postprandial Plasma Level of sRAGE in Humans Nutrients, 2022-04-30;14(9):. 2022-04-30 [PMID: 35565855] (Human) Human
KD Wick, L Siegel, JD Neaton, C Oldmixon, J Lundgren, RL Dewar, HC Lane, BT Thompson, MA Matthay, ACTIV-3/TI RAGE has potential pathogenetic and prognostic value in nonintubated hospitalized patients with COVID-19 JCI Insight, 2022-05-09;7(9):. 2022-05-09 [PMID: 35298440] (Human) Human
S Sin, MN Lim, J Kim, SH Bak, WJ Kim Association between plasma sRAGE and emphysema according to the genotypes of AGER gene BMC pulmonary medicine, 2022-02-10;22(1):58. 2022-02-10 [PMID: 35144588] (Human) Human
Show All 76 Publications.

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Bioinformatics

Gene Symbol AGER