Human RAGE Quantikine ELISA Kit

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

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Catalog# & Conjugate Size Price

Human RAGE Quantikine ELISA Kit Summary

Background
The Quantikine Human RAGE Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human RAGE (extracellular domain) in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant human RAGE/Fc Chimera and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human RAGE showed linear curves that were parallel to the standa...rd curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring RAGE.
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Specificity
Natural and recombinant human RAGE
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
AGER

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DRG00.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human RAGE Quantikine ELISA Kit

  • advanced glycosylation end product-specific receptor
  • AGER
  • RAGE isoform delta
  • RAGE isoform sRAGE-delta
  • RAGE
  • Receptor for advanced glycosylation end products
  • receptor for advanced glycosylation end-products
  • SCARJ1

Background

RAGE (Receptor for Advanced Glycation End product) is a transmembrane glycoprotein that binds advanced glycation end products (AGEs), beta-amyloid peptides, HMGB1/Amphoterin, and several S100 family proteins. AGEs are adducts formed by the non-enzymatic glycation and oxidation of proteins and lipids. A soluble form can also be generated by MMP-mediated shedding. RAGE is expressed in the CNS during development as well as in adult endothelial cells, smooth muscle cells, pericytes, monocytes, and neurons. It is locally upregulated in vascular inflammation (e.g. diabetes, atherosclerosis, vascular injury, Alzheimer’s disease). At these sites, RAGE binding to S100A1, EN-RAGE/S100A12, or S100B induces inflammatory immune cell adhesion and infiltration as well as vascular smooth muscle proliferation, neointimal expansion, atherosclerotic plaque development, and transport of A-beta into the cerebrospinal fluid. In cancer, RAGE binding to HMGB1, S100A8, or S100A9 promotes tumor growth and metastasis in addition to inflammatory cell infiltration.

To view our complete solutions for RAGE research, visit bio-techne.com.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for AGER (DRG00)(69)

We have publications tested in 2 confirmed species: Human, Chinese Hamster.


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Human
(68)
Chinese Hamster
(1)
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Showing Publications 1 - 10 of 69. Show All 69 Publications.
Publications using DRG00 Applications Species
C Helou, MT Nogueira S, C Niquet-Ler, P Jacolot, E Boulanger, F Delguste, A Guilbaud, M Genin, PM Anton, C Delayre-Or, T Papazian, M Howsam, FJ Tessier Plasma Levels of Free N?-Carboxymethyllysine (CML) after Different Oral Doses of CML in Rats and after the Intake of Different Breakfasts in Humans: Postprandial Plasma Level of sRAGE in Humans Nutrients, 2022;14(9):. 2022 [PMID: 35565855] (Human) Human
S Sin, MN Lim, J Kim, SH Bak, WJ Kim Association between plasma sRAGE and emphysema according to the genotypes of AGER gene BMC pulmonary medicine, 2022;22(1):58. 2022 [PMID: 35144588] (Human) Human
IA Drosatos, JN Tsoporis, S Izhar, S Gupta, G Tsirebolos, E Sakadakis, AS Triantafyl, A Rigopoulos, D Rigopoulos, LS Rallidis, I Rizos, TG Parker Differential Regulation of Circulating Soluble Receptor for Advanced Glycation End Products (sRAGEs) and Its Ligands S100A8/A9 Four Weeks Post an Exercise Intervention in a Cohort of Young Army Recruits Biomolecules, 2021;11(9):. 2021 [PMID: 34572568] (Human) Human
F Diekmann, P Chouvarine, H Sallmon, L Meyer-Kobb, M Kieslich, BD Plouffe, SK Murthy, R Lichtingha, E Legchenko, G Hansmann Soluble Receptor for Advanced Glycation End Products (sRAGE) Is a Sensitive Biomarker in Human Pulmonary Arterial Hypertension International Journal of Molecular Sciences, 2021;22(16):. 2021 [PMID: 34445297] (Human) Human
CD Ene, SR Georgescu, M Tampa, C Matei, CI Mitran, MI Mitran, MN Penescu, I Nicolae Cellular Response against Oxidative Stress, a Novel Insight into Lupus Nephritis Pathogenesis Journal of personalized medicine, 2021;11(8):. 2021 [PMID: 34442337] (Human) Human
TK Lazzari, E Cavalheiro, SE Coutinho, LF da Silva, DR Silva Leptin and advanced glycation end products receptor (RAGE) in tuberculosis patients PLoS ONE, 2021;16(7):e0254198. 2021 [PMID: 34214138] (Human) Human
C Gutmann, K Takov, SA Burnap, B Singh, H Ali, K Theofilato, E Reed, M Hasman, A Nabeebaccu, M Fish, MJ McPhail, K O'Gallaghe, LE Schmidt, C Cassel, M Rienks, X Yin, G Auzinger, S Napoli, SF Mujib, F Trovato, B Sanderson, B Merrick, U Niazi, M Saqi, K Dimitrakop, R Fernández-, S Braun, R Kronstein-, KJ Doores, JD Edgeworth, AM Shah, SR Bornstein, T Tonn, AC Hayday, M Giacca, M Shankar-Ha, M Mayr SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care Nature Communications, 2021;12(1):3406. 2021 [PMID: 34099652] (Human) Human
M Jabaudon, B Pereira, E Laroche, L Roszyk, R Blondonnet, J Audard, T Godet, E Futier, JE Bazin, V Sapin, JA Bastarache, LB Ware, JM Constantin, On Behalf Changes in Plasma Soluble Receptor for Advanced Glycation End-Products Are Associated with Survival in Patients with Acute Respiratory Distress Syndrome Journal of Clinical Medicine, 2021;10(10):. 2021 [PMID: 34066048] (Human) Human
CD Ene, MN Penescu, SR Georgescu, M Tampa, I Nicolae Posttranslational Modifications Pattern in Clear Cell Renal Cell Carcinoma Metabolites, 2020;11(1):. 2020 [PMID: 33375435] (Human) Human
X Zhou, N Lin, M Zhang, X Wang, Y An, Q Su, P Du, B Li, H Chen Circulating soluble receptor for advanced glycation end products and other factors in type 2 diabetes patients with colorectal cancer BMC Endocr Disord, 2020;20(1):170. 2020 [PMID: 33187505] (Human) Human
Show All 69 Publications.

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Bioinformatics

Gene Symbol AGER