Human RAGE Quantikine ELISA Kit

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

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Catalog# & Conjugate Size Price

Human RAGE Quantikine ELISA Kit Summary

Background
The Quantikine Human RAGE Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human RAGE (extracellular domain) in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant human RAGE/Fc Chimera and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human RAGE showed linear curves that were parallel to the standa...rd curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring RAGE.
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Specificity
Natural and recombinant human RAGE
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
AGER

Applications/Dilutions

Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DRG00.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human RAGE Quantikine ELISA Kit

  • advanced glycosylation end product-specific receptor
  • AGER
  • RAGE isoform delta
  • RAGE isoform sRAGE-delta
  • RAGE
  • Receptor for advanced glycosylation end products
  • receptor for advanced glycosylation end-products
  • SCARJ1

Background

RAGE (Receptor for Advanced Glycation End product) is a transmembrane glycoprotein that binds advanced glycation end products (AGEs), beta-amyloid peptides, HMGB1/Amphoterin, and several S100 family proteins. AGEs are adducts formed by the non-enzymatic glycation and oxidation of proteins and lipids. A soluble form can also be generated by MMP-mediated shedding. RAGE is expressed in the CNS during development as well as in adult endothelial cells, smooth muscle cells, pericytes, monocytes, and neurons. It is locally upregulated in vascular inflammation (e.g. diabetes, atherosclerosis, vascular injury, Alzheimer’s disease). At these sites, RAGE binding to S100A1, EN-RAGE/S100A12, or S100B induces inflammatory immune cell adhesion and infiltration as well as vascular smooth muscle proliferation, neointimal expansion, atherosclerotic plaque development, and transport of A-beta into the cerebrospinal fluid. In cancer, RAGE binding to HMGB1, S100A8, or S100A9 promotes tumor growth and metastasis in addition to inflammatory cell infiltration.

To view our complete solutions for RAGE research, visit bio-techne.com.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for AGER (DRG00)(53)

We have publications tested in 2 confirmed species: Human, Chinese Hamster.


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Human
(52)
Chinese Hamster
(1)
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Showing Publications 1 - 10 of 53. Show All 53 Publications.
Publications using DRG00 Applications Species
CL Vinton, CE Starke, AM Ortiz, SH Lai, JK Flynn, O Sortino, K Knox, I Sereti, JM Brenchley Biomarkers of Cellular Stress Do Not Associate with sCD14 in Progressive HIV and SIV Infections in Vivo Pathog Immun, 2020;5(1):68-88. 2020 [PMID: 32426577] (Human) Human
KB Holte, M Svanteson, KF Hanssen, KA Sveen, I Seljeflot, S Solheim, DR Sell, VM Monnier, TJ Berg Collagen methionine sulfoxide and glucuronidine/LW-1 are markers of coronary artery disease in long-term survivors with type 1 diabetes. The Dialong study PLoS ONE, 2020;15(5):e0233174. 2020 [PMID: 32401813] (Human) Human
H Ebert, ME Lacruz, A Kluttig, A Simm, KH Greiser, D Tiller, N Kartschmit, R Mikolajczy Association between advanced glycation end products, their soluble receptor, and mortality in the general population: Results from the CARLA study Exp. Gerontol., 2019;131(0):110815. 2019 [PMID: 31857132] (Human) Human
NP Kumar, K Moideen, A Nancy, V Viswanatha, BS Shruthi, S Sivakumar, S Hissar, H Kornfeld, S Babu Systemic RAGE ligands are upregulated in tuberculosis individuals with diabetes co-morbidity and modulated by anti-tuberculosis treatment and metformin therapy BMC Infect. Dis., 2019;19(1):1039. 2019 [PMID: 31818258] (Human) Human
FG Scurt, J Menne, S Brandt, A Bernhardt, PR Mertens, H Haller, C Chatzikyrk, Systemic Inflammation Precedes Microalbuminuria in Diabetes Kidney Int Rep, 2019;4(10):1373-1386. 2019 [PMID: 31701047] (Human) Human
H Ebert, ME Lacruz, A Kluttig, A Simm, KH Greiser, D Tiller, N Kartschmit, R Mikolajczy Advanced glycation end products and their ratio to soluble receptor are associated with limitations in physical functioning only in women: results from the CARLA cohort BMC Geriatr, 2019;19(1):299. 2019 [PMID: 31684879] (Human) Human
J Gelžinský, O Mayer, J Seidlerová, M Mate?ánkov, Š Mareš, V Kordíková, L Trefil, R Cífková, J Filipovský Soluble receptor for advanced glycation end-products independently influences individual age-dependent increase of arterial stiffness Hypertens. Res., 2019;0(0):. 2019 [PMID: 31636359] (Human) Human
VM Mendoza-Nú, BI García-Mar, J Rosado-Pér, E Santiago-O, J Pedraza-Ch, VJ Hernández- The Effect of 600 mg Alpha-lipoic Acid Supplementation on Oxidative Stress, Inflammation, and RAGE in Older Adults with Type 2 Diabetes Mellitus Oxid Med Cell Longev, 2019;2019(0):3276958. 2019 [PMID: 31285784] (Human) Human
A Abdulle, CK Inman, A Saleh, M Noshi, D Galani, L Abdelwaret, H Alsafar, A Elfatih, H Al Shamsi, R Ali, H Li, R Ramasamy, AM Schmidt, MM Benbarka, MH Hassan Metabolic dysfunction in Emirati subjects in Abu Dhabi: Relationship to levels of soluble RAGEs J Clin Transl Endocrinol, 2019;16(0):100192. 2019 [PMID: 31080742] (Human) Human
LF da Silva, EC Skupien, TK Lazzari, SR Holler, EGC de Almeida, LR Zampieri, SE Coutinho, M Andrades, DR Silva Advanced glycation end products (AGE) and receptor for AGE (RAGE) in patients with active tuberculosis, and their relationship between food intake and nutritional status PLoS ONE, 2019;14(3):e0213991. 2019 [PMID: 30870511] (Human) Human
Show All 53 Publications.

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FAQs for AGER (DRG00). (Showing 1 - 1 of 1 FAQs).

  1. wondering what the difference is between your quantikine and duo set elisas?
    • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

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Bioinformatics

Gene Symbol AGER