Human RAGE Quantikine ELISA Kit

• Reactivity: Hu
• Applications: ELISA
• Conjugate: HRP

Human RAGE Quantikine ELISA Kit Summary

• Background: The Quantikine Human RAGE Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human RAGE (extracellular domain) in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant human RAGE/Fc Chimera and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human RAGE showed linear curves that were parallel to the standa...rd curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring RAGE.
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• Specificity: Natural and recombinant human RAGE
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: AGER

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human RAGE Quantikine ELISA Kit

• advanced glycosylation end product-specific receptor
• AGER
• RAGE isoform delta
• RAGE isoform sRAGE-delta
• RAGE
• Receptor for advanced glycosylation end products
• receptor for advanced glycosylation end-products
• SCARJ1

Background

RAGE (Receptor for Advanced Glycation End product) is a transmembrane glycoprotein that binds advanced glycation end products (AGEs), beta-amyloid peptides, HMGB1/Amphoterin, and several S100 family proteins. AGEs are adducts formed by the non-enzymatic glycation and oxidation of proteins and lipids. A soluble form can also be generated by MMP-mediated shedding. RAGE is expressed in the CNS during development as well as in adult endothelial cells, smooth muscle cells, pericytes, monocytes, and neurons. It is locally upregulated in vascular inflammation (e.g. diabetes, atherosclerosis, vascular injury, Alzheimer’s disease). At these sites, RAGE binding to S100A1, EN-RAGE/S100A12, or S100B induces inflammatory immune cell adhesion and infiltration as well as vascular smooth muscle proliferation, neointimal expansion, atherosclerotic plaque development, and transport of A-beta into the cerebrospinal fluid. In cancer, RAGE binding to HMGB1, S100A8, or S100A9 promotes tumor growth and metastasis in addition to inflammatory cell infiltration.

To view our complete solutions for RAGE research, visit bio-techne.com.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for AGER (DRG00)(85)

Publications using DRG00

• Palermo, BJ;Wilkinson, KS;Plante, TB;Judd, SE;Mukaz, DK;Long, DL;Olson, NC;Smith, MJ;Cushman, M; Soluble receptor for advanced glycation end products and diabetes in Black and White Americans: the REGARDS Study Obesity medicine 2025-09-01 [PMID: 41307005] (Human)
• Neubauer-Geryk, J;My?liwiec, M;Zorena, K;Bieniaszewski, L; Parameters of Micro- and Macrocirculation in Young Uncomplicated Type 1 Diabetic Patients-The Role of Metabolic Memory International journal of molecular sciences 2025-10-18 [PMID: 41155446] (Human)
• Koike, H;Harada, M;Yoshida, K;Noda, K;Tsuchida, C;Fujiwara, T;Kusamoto, A;Xu, Z;Tanaka, T;Sakaguchi, N;Kunitomi, C;Takahashi, N;Urata, Y;Sone, K;Wada-Hiraike, O;Hirota, Y;Osuga, Y; Assessment and prediction models for the quantitative and qualitative reserve of the ovary using machine learning Journal of ovarian research 2025-07-18 [PMID: 40676609] (Human)
• Kitadai, E;Yamaguchi, K;Ohshimo, S;Iwamoto, H;Sakamoto, S;Horimasu, Y;Masuda, T;Nakashima, T;Hamada, H;Bonella, F;Guzman, J;Costabel, U;Hattori, N; Serum soluble isoform of receptor for advanced glycation end product is a predictive biomarker for acute exacerbation of idiopathic pulmonary fibrosis: a German and Japanese cohort study Respiratory research 2024-11-11 [PMID: 39529063] (Human)
• Charoenvicha, C;Thongsroy, J;Apaijai, N;Attachaipanich, T;Sirimaharaj, W;Khwanngern, K;Chattipakorn, N;Mutirangura, A;Chattipakorn, SC; Alterations of senescence-associated markers in patients with non-syndromic cleft lip and palate Scientific reports 2024-09-29 [PMID: 39343816] (Human)
• Ye, D;Miyoshi, A;Ushitani, T;Kadoya, M;Igeta, M;Konishi, K;Shoji, T;Yasuda, K;Kitaoka, S;Yagi, H;Kuroda, E;Yamamoto, Y;Cheng, J;Koyama, H; RAGE in circulating immune cells is fundamental for hippocampal inflammation and cognitive decline in a mouse model of latent chronic inflammation Brain, behavior, and immunity 2023-12-22 [PMID: 38142917] (Transgenic Mouse)
• Perkins, RK;Miranda, ER;Varshney, P;Farabi, SS;Quinn, LT;Haus, JM; Effects of acute aerobic exercise on circulating sTLR and sRAGE profiles in normal- and abnormal-glucose-tolerant individuals Physiological reports 2023-11-01 [PMID: 37985201] (Human)
• Meza-Fuentes, G;López, R;Vial, C;Cortes, LJ;Retamal, MA;Delgado, I;Vial, P; Assessing Pulmonary Epithelial Damage in Hantavirus Cardiopulmonary Syndrome: Challenging the Predominant Role of Vascular Endothelium through sRAGE as a Potential Biomarker Viruses 2023-09-26 [PMID: 37896774] (Human)
• Schröder, L;Rupp, ABA;Gihr, KME;Kobilay, M;Domroese, CM;Mallmann, MR;Holdenrieder, S; Immunogenic Biomarkers HMGB1 and sRAGE Are Potential Diagnostic Tools for Ovarian Malignancies Cancers 2023-10-20 [PMID: 37894448] (Human)
• Elsadek, MF; Effectiveness of two photosensitizer-mediated photodynamic therapy for treating moderate peri-implant infections in type-II diabetes mellitus patients: A randomized clinical trial Photodiagnosis and photodynamic therapy 2023-06-01 [PMID: 37270045] (Human)
• SJ Barnard, J Haunschild, L Heiser, MT Dieterlen, K Klaeske, MA Borger, CD Etz Apoptotic Cell Death in Bicuspid-Aortic-Valve-Associated Aortopathy International Journal of Molecular Sciences, 2023-04-18;24(8):. 2023-04-18 [PMID: 37108591] (Human)
• Y Peng, F Liu, Y Qiao, P Wang, H Du, C Si, X Wang, K Chen, F Song Genetically Modified Circulating Levels of Advanced Glycation End-Products and Their Soluble Receptor (AGEs-RAGE Axis) with Risk and Mortality of Breast Cancer Cancers, 2022-12-12;14(24):. 2022-12-12 [PMID: 36551607] (Human)
• L Butcher, JC Zaldua, JA Carnicero, K Hawkins, J Whitley, R Mothukuri, PA Evans, K Morris, S Pillai, JD Erusalimsk High levels of soluble RAGE are associated with a greater risk of mortality in COVID-19 patients treated with dexamethasone Respiratory Research, 2022-11-05;23(1):303. 2022-11-05 [PMID: 36335329] (Human)
• S Reichert, B Hofmann, M Kohnert, AN Santos, L Friebe, J Grollmitz, HG Schaller, S Schulz Advanced Glycation End Product (AGE) and Soluble Receptor of AGE (sRAGE) Levels in Relation to Periodontitis Severity and as Putative 3-Year Outcome Predictors in Patients Undergoing Coronary Artery Bypass Grafting (CABG) Journal of Clinical Medicine, 2022-07-15;11(14):. 2022-07-15 [PMID: 35887868] (Human)
• E Galliera, L Massaccesi, L Yu, J He, M Ranucci, MM Corsi Roma SCD14-ST and New Generation Inflammatory Biomarkers in the Prediction of COVID-19 Outcome Biomolecules, 2022-06-13;12(6):. 2022-06-13 [PMID: 35740951] (Human)
• A Karas, D Holmannova, P Borsky, Z Fiala, C Andrys, K Hamakova, T Svadlakova, V Palicka, J Krejsek, V Rehacek, M Esterkova, H Kovarikova, L Borska Significantly Altered Serum Levels of NAD, AGE, RAGE, CRP, and Elastin as Potential Biomarkers of Psoriasis and Aging-A Case-Control Study Biomedicines, 2022-05-13;10(5):. 2022-05-13 [PMID: 35625870] (Human)
• C Helou, MT Nogueira S, C Niquet-Ler, P Jacolot, E Boulanger, F Delguste, A Guilbaud, M Genin, PM Anton, C Delayre-Or, T Papazian, M Howsam, FJ Tessier Plasma Levels of Free N?-Carboxymethyllysine (CML) after Different Oral Doses of CML in Rats and after the Intake of Different Breakfasts in Humans: Postprandial Plasma Level of sRAGE in Humans Nutrients, 2022-04-30;14(9):. 2022-04-30 [PMID: 35565855] (Human)
• KD Wick, L Siegel, JD Neaton, C Oldmixon, J Lundgren, RL Dewar, HC Lane, BT Thompson, MA Matthay, ACTIV-3/TI RAGE has potential pathogenetic and prognostic value in nonintubated hospitalized patients with COVID-19 JCI Insight, 2022-05-09;7(9):. 2022-05-09 [PMID: 35298440] (Human)
• S Sin, MN Lim, J Kim, SH Bak, WJ Kim Association between plasma sRAGE and emphysema according to the genotypes of AGER gene BMC pulmonary medicine, 2022-02-10;22(1):58. 2022-02-10 [PMID: 35144588] (Human)
• IA Drosatos, JN Tsoporis, S Izhar, S Gupta, G Tsirebolos, E Sakadakis, AS Triantafyl, A Rigopoulos, D Rigopoulos, LS Rallidis, I Rizos, TG Parker Differential Regulation of Circulating Soluble Receptor for Advanced Glycation End Products (sRAGEs) and Its Ligands S100A8/A9 Four Weeks Post an Exercise Intervention in a Cohort of Young Army Recruits Biomolecules, 2021-09-13;11(9):. 2021-09-13 [PMID: 34572568] (Human)
• F Diekmann, P Chouvarine, H Sallmon, L Meyer-Kobb, M Kieslich, BD Plouffe, SK Murthy, R Lichtingha, E Legchenko, G Hansmann Soluble Receptor for Advanced Glycation End Products (sRAGE) Is a Sensitive Biomarker in Human Pulmonary Arterial Hypertension International Journal of Molecular Sciences, 2021-08-10;22(16):. 2021-08-10 [PMID: 34445297] (Human)
• CD Ene, SR Georgescu, M Tampa, C Matei, CI Mitran, MI Mitran, MN Penescu, I Nicolae Cellular Response against Oxidative Stress, a Novel Insight into Lupus Nephritis Pathogenesis Journal of personalized medicine, 2021-07-22;11(8):. 2021-07-22 [PMID: 34442337] (Human)
• TK Lazzari, E Cavalheiro, SE Coutinho, LF da Silva, DR Silva Leptin and advanced glycation end products receptor (RAGE) in tuberculosis patients PLoS ONE, 2021-07-02;16(7):e0254198. 2021-07-02 [PMID: 34214138] (Human)
• C Gutmann, K Takov, SA Burnap, B Singh, H Ali, K Theofilato, E Reed, M Hasman, A Nabeebaccu, M Fish, MJ McPhail, K O'Gallaghe, LE Schmidt, C Cassel, M Rienks, X Yin, G Auzinger, S Napoli, SF Mujib, F Trovato, B Sanderson, B Merrick, U Niazi, M Saqi, K Dimitrakop, R Fernández-, S Braun, R Kronstein-, KJ Doores, JD Edgeworth, AM Shah, SR Bornstein, T Tonn, AC Hayday, M Giacca, M Shankar-Ha, M Mayr SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care Nature Communications, 2021-06-07;12(1):3406. 2021-06-07 [PMID: 34099652] (Human)
• M Jabaudon, B Pereira, E Laroche, L Roszyk, R Blondonnet, J Audard, T Godet, E Futier, JE Bazin, V Sapin, JA Bastarache, LB Ware, JM Constantin, On Behalf Changes in Plasma Soluble Receptor for Advanced Glycation End-Products Are Associated with Survival in Patients with Acute Respiratory Distress Syndrome Journal of Clinical Medicine, 2021-05-12;10(10):. 2021-05-12 [PMID: 34066048] (Human)
• CD Ene, MN Penescu, SR Georgescu, M Tampa, I Nicolae Posttranslational Modifications Pattern in Clear Cell Renal Cell Carcinoma Metabolites, 2020-12-27;11(1):. 2020-12-27 [PMID: 33375435] (Human)
• X Zhou, N Lin, M Zhang, X Wang, Y An, Q Su, P Du, B Li, H Chen Circulating soluble receptor for advanced glycation end products and other factors in type 2 diabetes patients with colorectal cancer BMC Endocr Disord, 2020-11-13;20(1):170. 2020-11-13 [PMID: 33187505] (Human)
• RC C, B Lukose, P Rani G82S RAGE polymorphism influences amyloid-RAGE interactions relevant in Alzheimer's disease pathology PLoS ONE, 2020-10-29;15(10):e0225487. 2020-10-29 [PMID: 33119615] (Human)
• P Swami, S Thiyagaraj, A Vidger, VSK Indurthi, SW Vetter, E Leclerc RAGE Up-Regulation Differently Affects Cell Proliferation and Migration in Pancreatic Cancer Cells Int J Mol Sci, 2020-10-19;21(20):. 2020-10-19 [PMID: 33086527] (Human)
• E Korça, V Piskovatsk, J Börgermann, A Navarrete, A Simm Circulating antibodies against age-modified proteins in patients with coronary atherosclerosis Sci Rep, 2020-10-13;10(1):17105. 2020-10-13 [PMID: 33051525] (Human)
• O Bourron, F Phan, MH Diallo, D Hajage, CE Aubert, A Carlier, JE Salem, C Funck-Bren, S Kemel, P Cluzel, A Redheuil, JM Davaine, Z Massy, R Mentaverri, D Bonnefont-, P Gillery, S Jaisson, C Vermeer, JM Lacorte, N Bouziri, S Laroche, C Amouyal, A Hartemann Circulating Receptor Activator of Nuclear Factor kB Ligand and triglycerides are associated with progression of lower limb arterial calcification in type 2 diabetes: a prospective, observational cohort study Cardiovascular Diabetology, 2020-09-18;19(1):140. 2020-09-18 [PMID: 32948184] (Human)
• CL Vinton, CE Starke, AM Ortiz, SH Lai, JK Flynn, O Sortino, K Knox, I Sereti, JM Brenchley Biomarkers of Cellular Stress Do Not Associate with sCD14 in Progressive HIV and SIV Infections in Vivo Pathog Immun, 2020-04-24;5(1):68-88. 2020-04-24 [PMID: 32426577] (Human)
• KB Holte, M Svanteson, KF Hanssen, KA Sveen, I Seljeflot, S Solheim, DR Sell, VM Monnier, TJ Berg Collagen methionine sulfoxide and glucuronidine/LW-1 are markers of coronary artery disease in long-term survivors with type 1 diabetes. The Dialong study PLoS ONE, 2020-05-13;15(5):e0233174. 2020-05-13 [PMID: 32401813] (Human)
• H Ebert, ME Lacruz, A Kluttig, A Simm, KH Greiser, D Tiller, N Kartschmit, R Mikolajczy Association between advanced glycation end products, their soluble receptor, and mortality in the general population: Results from the CARLA study Exp. Gerontol., 2019-12-16;131(0):110815. 2019-12-16 [PMID: 31857132] (Human)
• NP Kumar, K Moideen, A Nancy, V Viswanatha, BS Shruthi, S Sivakumar, S Hissar, H Kornfeld, S Babu Systemic RAGE ligands are upregulated in tuberculosis individuals with diabetes co-morbidity and modulated by anti-tuberculosis treatment and metformin therapy BMC Infect. Dis., 2019-12-09;19(1):1039. 2019-12-09 [PMID: 31818258] (Human)
• FG Scurt, J Menne, S Brandt, A Bernhardt, PR Mertens, H Haller, C Chatzikyrk Systemic Inflammation Precedes Microalbuminuria in Diabetes Kidney Int Rep, 2019-06-21;4(10):1373-1386. 2019-06-21 [PMID: 31701047] (Human)
• H Ebert, ME Lacruz, A Kluttig, A Simm, KH Greiser, D Tiller, N Kartschmit, R Mikolajczy Advanced glycation end products and their ratio to soluble receptor are associated with limitations in physical functioning only in women: results from the CARLA cohort BMC Geriatr, 2019-11-04;19(1):299. 2019-11-04 [PMID: 31684879] (Human)
• J Gelžinský, O Mayer, J Seidlerová, M Mate?ánkov, Š Mareš, V Kordíková, L Trefil, R Cífková, J Filipovský Soluble receptor for advanced glycation end-products independently influences individual age-dependent increase of arterial stiffness Hypertens. Res., 2019-10-21;0(0):. 2019-10-21 [PMID: 31636359] (Human)
• VM Mendoza-Nú, BI García-Mar, J Rosado-Pér, E Santiago-O, J Pedraza-Ch, VJ Hernández- The Effect of 600 mg Alpha-lipoic Acid Supplementation on Oxidative Stress, Inflammation, and RAGE in Older Adults with Type 2 Diabetes Mellitus Oxid Med Cell Longev, 2019-06-12;2019(0):3276958. 2019-06-12 [PMID: 31285784] (Human)
• EDC Ruelas Cin, B Ruíz Madri, JA Domínguez, M Maldonado, L De la Cruz, SM Ramírez Me, JR Torres Bar, E Martínez L, ZH Hernández Expression of the receptor of advanced glycation end-products (RAGE) and membranal location in peripheral blood mononuclear cells (PBMC) in obesity and insulin resistance Iran J Basic Med Sci, 2019-06-01;22(6):623-630. 2019-06-01 [PMID: 31231489] (Human)
• A Abdulle, CK Inman, A Saleh, M Noshi, D Galani, L Abdelwaret, H Alsafar, A Elfatih, H Al Shamsi, R Ali, H Li, R Ramasamy, AM Schmidt, MM Benbarka, MH Hassan Metabolic dysfunction in Emirati subjects in Abu Dhabi: Relationship to levels of soluble RAGEs J Clin Transl Endocrinol, 2019-04-23;16(0):100192. 2019-04-23 [PMID: 31080742] (Human)
• LF da Silva, EC Skupien, TK Lazzari, SR Holler, EGC de Almeida, LR Zampieri, SE Coutinho, M Andrades, DR Silva Advanced glycation end products (AGE) and receptor for AGE (RAGE) in patients with active tuberculosis, and their relationship between food intake and nutritional status PLoS ONE, 2019-03-14;14(3):e0213991. 2019-03-14 [PMID: 30870511] (Human)
• CJ Popp, DE St-Jules, L Hu, L Ganguzza, P Illiano, M Curran, H Li, A Schoenthal, M Bergman, AM Schmidt, E Segal, A Godneva, MA Sevick The rationale and design of the personal diet study, a randomized clinical trial evaluating a personalized approach to weight loss in individuals with pre-diabetes and early-stage type 2 diabetes Contemp Clin Trials, 2019-03-04;0(0):. 2019-03-04 [PMID: 30844471] (Human)
• AM Maresca, L Guasti, S Bozzini, C Mongiardi, N Tandurella, R Corso, FG Zerba, A Squizzato, L Campiotti, F Dentali, C Klersy, AM Grandi, C Falcone sRAGE and early signs of cardiac target organ damage in mild hypertensives Cardiovasc Diabetol, 2019-02-12;18(1):17. 2019-02-12 [PMID: 30755202] (Human)
• KH Chiang, JW Chen, SS Huang, HB Leu, SJ Lin, PH Huang The ratio of AGE to sRAGE independently associated with albuminuria in hypertensive patients BMC Endocr Disord, 2018-11-13;18(1):84. 2018-11-13 [PMID: 30424768] (Human)
• C Machahua, A Montes-Wor, L Planas-Cer, R Buendia-Fl, M Molina-Mol, V Vicens-Zyg Serum AGE/RAGEs as potential biomarker in idiopathic pulmonary fibrosis Respir. Res., 2018-11-08;19(1):215. 2018-11-08 [PMID: 30409203] (Human)
• F Klont, MR Joosten, NHT Ten Hacken, P Horvatovic, R Bischoff Quantification of the soluble Receptor of Advanced Glycation End-Products (sRAGE) by LC-MS after enrichment by strong cation exchange (SCX) solid-phase extraction (SPE) at the protein level Anal. Chim. Acta, 2018-09-29;1043(0):45-51. 2018-09-29 [PMID: 30392668] (Human)
• DL White, RC Hoogeveen, L Chen, P Richardson, M Ravishanka, P Shah, L Tinker, T Rohan, EA Whitsel, HB El-Serag, L Jiao A prospective study of soluble receptor for advanced glycation end products and adipokines in association with pancreatic cancer in postmenopausal women Cancer Med, 2018-03-23;0(0):. 2018-03-23 [PMID: 29573228] (Human)
• M Jabaudon, P Berthelin, T Pranal, L Roszyk, T Godet, JS Faure, R Chabanne, N Eisenmann, A Lautrette, C Belville, R Blondonnet, S Cayot, T Gillart, J Pascal, Y Skrzypczak, B Souweine, L Blanchon, V Sapin, B Pereira, JM Constantin Receptor for advanced glycation end-products and ARDS prediction: a multicentre observational study Sci Rep, 2018-02-08;8(1):2603. 2018-02-08 [PMID: 29422518] (Human)
• W Zhu, BC Kim, M Wang, J Huang, A Isak, NM Bexiga, R Monticone, T Ha, EG Lakatta, SS An TGF?1 reinforces arterial aging in the vascular smooth muscle cell through a long-range regulation of the cytoskeletal stiffness Sci Rep, 2018-02-08;8(1):2668. 2018-02-08 [PMID: 29422510] (Human)
• L Srinivasan, L Kilpatrick, SS Shah, S Abbasi, MC Harris Elevations of novel cytokines in bacterial meningitis in infants PLoS ONE, 2018-02-02;13(2):e0181449. 2018-02-02 [PMID: 29394248] (Human)
• B Paradela-D, Á Fernández-, D Bou-Teen, S Eiras, R González-F, RM Agra, A Varela-Rom, AI Castro-Pai, MC Carreira, FF Casanueva, E Álvarez, JR González-J Evolution and bad prognostic value of advanced glycation end products after acute heart failure: relation with body composition Cardiovasc Diabetol, 2017-09-15;16(1):115. 2017-09-15 [PMID: 28915840] (Human)
• LL Negrin, G Halat, S Kettner, M Gregori, R Ristl, S Hajdu, T Heinz Club cell protein 16 and cytokeratin fragment 21-1 as early predictors of pulmonary complications in polytraumatized patients with severe chest trauma PLoS ONE, 2017-04-05;12(4):e0175303. 2017-04-05 [PMID: 28380043] (Human)
• Karen Ingrid Tasca The Initial Months of Antiretroviral Therapy and Its Influence on AGEs, HMGB1, and sRAGE Levels in Asymptomatic HIV-Infected Individuals Mediators Inflamm, 2016-11-30;2016(0):2909576. 2016-11-30 [PMID: 28042203] (Human)
• BiJun Wang Decreased levels of sRAGE in follicular fluid from patients with PCOS Reproduction, 2016-12-13;0(0):. 2016-12-13 [PMID: 27965400] (Human)
• Innovative Flow Cytometry Allows Accurate Identification of Rare Circulating Cells Involved in Endothelial Dysfunction PLoS ONE, 2016-08-25;11(8):e0160153. 2016-08-25 [PMID: 27560136] (Human)
• Heier M, Margeirsdottir H, Gaarder M, Stensaeth K, Brunborg C, Torjesen P, Seljeflot I, Hanssen K, Dahl-Jorgensen K Soluble RAGE and atherosclerosis in youth with type 1 diabetes: a 5-year follow-up study. Cardiovasc Diabetol, 2015-09-25;14(1):126. 2015-09-25 [PMID: 26408307] (Human)
• Lee A, Lam J, Shiu S, Wong Y, Betteridge D, Tan K Serum Level of Soluble Receptor for Advanced Glycation End Products Is Associated with A Disintegrin And Metalloproteinase 10 in Type 1 Diabetes. PLoS ONE, 2015-09-01;10(9):e0137330. 2015-09-01 [PMID: 26325204] (Human)
• Jabaudon M, Blondonnet R, Roszyk L, Pereira B, Guerin R, Perbet S, Cayot S, Bouvier D, Blanchon L, Sapin V, Constantin J Soluble Forms and Ligands of the Receptor for Advanced Glycation End-Products in Patients with Acute Respiratory Distress Syndrome: An Observational Prospective Study. PLoS ONE, 2015-08-14;10(8):e0135857. 2015-08-14 [PMID: 26274928] (Human)
• Chou C, Lin F, Tsai H, Chang S The impact of concomitant pulmonary infection on immune dysregulation in Pneumocystis jirovecii pneumonia. BMC Pulm Med, 2014-11-19;14(0):182. 2014-11-19 [PMID: 25409888] (Human)
• Moser B, Megerle A, Bekos C, Janik S, Szerafin T, Birner P, Schiefer A, Mildner M, Lang I, Skoro-Sajer N, Sadushi-Kolici R, Taghavi S, Klepetko W, Ankersmit H Local and systemic RAGE axis changes in pulmonary hypertension: CTEPH and iPAH. PLoS ONE, 2014-09-04;9(9):e106440. 2014-09-04 [PMID: 25188497] (Human)
• Momma H, Niu K, Kobayashi Y, Huang C, Chujo M, Otomo A, Tadaura H, Miyata T, Nagatomi R Higher serum soluble receptor for advanced glycation end product levels and lower prevalence of metabolic syndrome among Japanese adult men: a cross-sectional study. Diabetol Metab Syndr, 2014-03-06;6(1):33. 2014-03-06 [PMID: 24602408] (Human)
• Wei , Wen, Kim , Ji Min, Medina , Danny, Lakatta , Edward G, Lin , Li GeneOptimizer program-assisted cDNA reengineering enhances sRAGE autologous expression in Chinese hamster ovary cells. Protein Expr Purif, 2013-12-25;95(0):143-8. 2013-12-25 [PMID: 24373844] (Chinese Hamster)
• Zakiyanov O, Kriha V, Vachek J, Zima T, Tesar V, Kalousova M Placental growth factor, pregnancy-associated plasma protein-A, soluble receptor for advanced glycation end products, extracellular newly identified receptor for receptor for advanced glycation end products binding protein and high mobility group box 1 levels in patients with acute kidney injury: a cross sectional study. BMC Nephrol, 2013-11-04;14(0):245. 2013-11-04 [PMID: 24188108] (Human)
• Campbell D, Somaratne J, Jenkins A, Prior D, Yii M, Kenny J, Newcomb A, Schalkwijk C, Black M, Kelly D Diastolic dysfunction of aging is independent of myocardial structure but associated with plasma advanced glycation end-product levels. PLoS ONE, 2012-11-26;7(11):e49813. 2012-11-26 [PMID: 23189164] (Human)
• Brix J, Hollerl F, Kopp H, Schernthaner G, Schernthaner G The soluble form of the receptor of advanced glycation endproducts increases after bariatric surgery in morbid obesity. Int J Obes (Lond), 2012-07-17;36(11):1412-7. 2012-07-17 [PMID: 22828946] (Human)
• Wittwer C, Lehner J, Fersching D, Siegele B, Stoetzer OJ, Holdenrieder S Methodological and Preanalytical Evaluation of a RAGE Immunoassay. Anticancer Res., 2012-05-01;32(5):2075-8. 2012-05-01 [PMID: 22593491] (Human)
• Narvaez-Rivera RM, Rendon A, Salinas-Carmona MC Soluble RAGE as a severity marker in community acquired pneumonia associated sepsis. BMC Infect. Dis., 2012-01-20;12(0):15. 2012-01-20 [PMID: 22264245] (Human)
• Colhoun HM, Betteridge DJ, Durrington P, Hitman G, Neil A, Livingstone S, Charlton-Menys V, Bao W, Demicco DA, Preston GM, Deshmukh H, Tan K, Fuller JH Total soluble and endogenous secretory receptor for advanced glycation end products as predictive biomarkers of coronary heart disease risk in patients with type 2 diabetes: an analysis from the CARDS trial. Diabetes, 2011-07-19;60(9):2379-85. 2011-07-19 [PMID: 21771973] (Human)
• Yamakawa N, Uchida T, Matthay MA, Makita K Proteolytic release of the receptor for advanced glycation end products from in vitro and in situ alveolar epithelial cells. Am. J. Physiol. Lung Cell Mol. Physiol., 2011-01-21;300(4):L516-25. 2011-01-21 [PMID: 21257730] (Human)
• Jabaudon M, Futier E, Roszyk L Soluble form of the receptor for advanced glycation end products is a marker of acute lung injury but not of severe sepsis in critically ill patients. Crit. Care Med., 2011-03-01;39(3):480-8. 2011-03-01 [PMID: 21220996] (Human)
• Nin JW, Jorsal A, Ferreira I Higher plasma soluble Receptor for Advanced Glycation End Products (sRAGE) levels are associated with incident cardiovascular disease and all-cause mortality in type 1 diabetes: a 12-year follow-up study. Diabetes, 2010-06-03;59(8):2027-32. 2010-06-03 [PMID: 20522598] (Human)
• Penfold SA, Coughlan MT, Patel SK Circulating high-molecular-weight RAGE ligands activate pathways implicated in the development of diabetic nephropathy. Kidney Int., 2010-05-12;78(3):287-95. 2010-05-12 [PMID: 20463655] (Human)
• Tam HL, Shiu SW, Wong Y, Chow WS, Betteridge DJ, Tan KC Effects of atorvastatin on serum soluble receptors for advanced glycation end-products in type 2 diabetes. Atherosclerosis, 2009-08-21;209(1):173-7. 2009-08-21 [PMID: 19733353] (Human)
• Bastarache JA, Fremont RD, Kropski JA, Bossert FR, Ware LB Procoagulant alveolar microparticles in the lungs of patients with acute respiratory distress syndrome. Am. J. Physiol. Lung Cell Mol. Physiol., 2009-08-21;297(6):L1035-41. 2009-08-21 [PMID: 19700643] (Human)
• Buhimschi CS, Baumbusch MA, Dulay AT, Oliver EA, Lee S, Zhao G, Bhandari V, Ehrenkranz RA, Weiner CP, Madri JA, Buhimschi IA Characterization of RAGE, HMGB1, and S100beta in inflammation-induced preterm birth and fetal tissue injury. Am. J. Pathol., 2009-08-13;175(3):958-75. 2009-08-13 [PMID: 19679874] (Human)
• Mahajan N, Malik N, Bahl A Receptor for advanced glycation end products (RAGE) and its inflammatory ligand EN-RAGE in non-diabetic subjects with pre-mature coronary artery disease. Atherosclerosis, 2009-06-11;207(2):597-602. 2009-06-11 [PMID: 19576587] (Human)
• Makam M, Diaz D, Laval J, Gernez Y, Conrad CK, Dunn CE, Davies ZA, Moss RB, Herzenberg LA, Herzenberg LA, Tirouvanziam R Activation of critical, host-induced, metabolic and stress pathways marks neutrophil entry into cystic fibrosis lungs. Proc. Natl. Acad. Sci. U.S.A., 2009-03-17;106(14):5779-83. 2009-03-17 [PMID: 19293384] (Human)
• Yan XX, Lu L, Peng WH, Wang LJ, Zhang Q, Zhang RY, Chen QJ, Shen WF Increased serum HMGB1 level is associated with coronary artery disease in nondiabetic and type 2 diabetic patients. Atherosclerosis, 2008-12-14;205(2):544-8. 2008-12-14 [PMID: 19150066] (Human)
• Serum-soluble receptor for advanced glycation end product levels in patients with amyotrophic lateral sclerosis. Acta Neurol. Scand., 2008-12-02;120(2):119-22. 2008-12-02 [PMID: 19053950] (Human)
• Katakami N, Matsuhisa M, Kaneto H, Matsuoka TA, Sakamoto K, Yasuda T, Umayahara Y, Kosugi K, Yamasaki Y Serum endogenous secretory RAGE level is an independent risk factor for the progression of carotid atherosclerosis in type 1 diabetes. Atherosclerosis, 2008-09-02;204(1):288-92. 2008-09-02 [PMID: 18926539] (Human)
• Hallstrom L, Berghall E, Frostell C, Sollevi A, Soop AL Nitric oxide inhalation and glucocorticoids as combined treatment in human experimental endotoxemia. Crit. Care Med., 2008-11-01;36(11):3043-7. 2008-11-01 [PMID: 18824917] (Human)
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• Rosas IO, Richards TJ, Konishi K, Zhang Y, Gibson K, Lokshin AE, Lindell KO, Cisneros J, Macdonald SD, Pardo A, Sciurba F, Dauber J, Selman M, Gochuico BR, Kaminski N MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis. PLoS Med., 2008-04-29;5(4):e93. 2008-04-29 [PMID: 18447576] (Human)
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FAQs for AGER (DRG00). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: AGER