Human Progranulin Quantikine ELISA Kit

• Reactivity: Hu
• Applications: ELISA
• Conjugate: HRP

Human Progranulin Quantikine ELISA Kit Summary

• Background: The Quantikine Human Progranulin immunoassay is a 4.5 hour solid phase ELISA designed to measure Progranulin in cell culture supernates, serum, plasma, saliva, urine, and human milk. It contains NS0-expressed recombinant human Progranulin and has been shown to accurately quantitate the recombinant factor. Results obtained using natural Progranulin showed linear curves that were parallel to t...he standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring human Progranulin.
  Show More
• Additional Information: Not Available in Europe
• Specificity: Natural and recombinant human Progranulin. Trypsin and Elastase cleaved Progranulin show reduced recognition in this assay, demonstrating specificity for Progranulin.
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: GRN

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Progranulin Quantikine ELISA Kit

• Acrogranin
• CLN11
• GEP
• GP88
• granulin precursor
• GRN
• PCDGF
• PEPI
• PGRN
• Proepithelin
• Progranulin

Background

Progranulin, also known as Acrogranin, PCDGF, and Epithelin/Granulin Precursor, is a widely expressed glycoprotein that can undergo proteolysis to generate numerous Granulin peptides. Progranulin plays a role in the regulation of mesothelial differentiation, macrophage development, sexual differentiation of the brain, cartilage proliferation, wound repair, and the development of rheumatoid arthritis and osteoarthritis. It is often upregulated in cancer and contributes to tumor progression. Progranulin upregulation or mutation is associated with several neurological disorders including frontotemporal dementia, Creutzfeldt-Jakob disease, Alzheimer’s disease, and motor neuron disease.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for Progranulin/PGRN (DPGRN0)(18)

Publications using DPGRN0

• He, Y;Kaya, I;Shariatgorji, R;Lundkvist, J;Wahlberg, LU;Nilsson, A;Mamula, D;Kehr, J;Zareba-Paslawska, J;Biverstål, H;Chergui, K;Zhang, X;Andren, PE;Svenningsson, P; Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents Nature communications 2023-09-19 [PMID: 37726325] (Human)
• Tóth, NM;Müller, V;Nagy, T;Polivka, L;Horváth, P;Bohács, A;Eszes, N; Serum Progranulin Level Might Differentiate Non-IPF ILD from IPF International journal of molecular sciences 2023-05-24 [PMID: 37298130] (Human)
• T Gohda, M Murakoshi, Y Suzuki, M Hiki, T Naito, K Takahashi, Y Tabe Circulating tumor necrosis factor receptors are associated with mortality and disease severity in COVID-19 patients PLoS ONE, 2022-10-11;17(10):e0275745. 2022-10-11 [PMID: 36219652] (Human)
• C Raposo-Lim, IM Pereira, F Marques, P Morgado Elevated levels of neutrophil gelatinase-associated lipocalin among OCD patients: an exploratory study BMC Psychiatry, 2021-05-26;21(1):272. 2021-05-26 [PMID: 34039300] (Human)
• T Samejima, T Nagamatsu, N Akiba, T Fujii, S Sayama, K Kawana, A Taguchi, K Kumasawa, T Iriyama, Y Osuga, T Fujii Secretory leukocyte protease inhibitor and progranulin as possible regulators of cervical remodeling in pregnancy J Reprod Immunol, 2020-11-01;143(0):103241. 2020-11-01 [PMID: 33157500] (Human)
• AD Nguyen, TK Malmstrom, ML Niehoff, A Aziz, DK Miller, JE Morley Serum progranulin levels are associated with frailty in middle-aged individuals PLoS ONE, 2020-09-04;15(9):e0238877. 2020-09-04 [PMID: 32886731] (Human)
• L Rao, Z Song, X Yu, Q Tu, Y He, Y Luo, Y Yin, D Chen Progranulin as a novel biomarker in diagnosis of early-onset neonatal sepsis Cytokine, 2020-01-23;128(0):155000. 2020-01-23 [PMID: 31982701] (Human)
• K Schmitz, A Wilken-Sch, V Vasic, R Brunkhorst, M Schmidt, I Tegeder Progranulin deficiency confers resistance to autoimmune encephalomyelitis in mice Cell. Mol. Immunol., 2019-08-29;0(0):. 2019-08-29 [PMID: 31467413] (Human)
• BB Nicoletto, RA Sarmento, EF Pedrollo, TC Krolikowsk, LH Canani Association between progranulin serum levels and dietary intake PLoS ONE, 2018-08-17;13(8):e0202149. 2018-08-17 [PMID: 30118483] (Human)
• GS Choi, HKT Trinh, EM Yang, YM Ye, YS Shin, SH Kim, HS Park Role of clusterin/progranulin in toluene diisocyanate-induced occupational asthma Exp. Mol. Med., 2018-05-01;50(5):58. 2018-05-01 [PMID: 29717106] (Human)
• Identifying biomarkers of dementia prevalent among amnestic mild cognitively impaired ethnic female patients Alzheimers Res Ther, 2016-10-18;8(1):43. 2016-10-18 [PMID: 27756387] (Human)
• p38 MAPK alpha mediates cytokine-induced IL-6 and MMP-3 expression in human cardiac fibroblasts. Biochem Biophys Res Commun, 2012-12-01;430(1):419-24. 2012-12-01 [PMID: 23206705] (Mouse)
• Richter J, Focke D, Ebert T, Kovacs P, Bachmann A, Lossner U, Kralisch S, Kratzsch J, Beige J, Anders M, Bast I, Bluher M, Stumvoll M, Fasshauer M Serum levels of the adipokine progranulin depend on renal function. Diabetes Care, 2012-10-01;36(2):410-4. 2012-10-01 [PMID: 23033238] (Human)
• Gass J, Lee W, Cook C, Finch N, Stetler C, Jansen-West K, Lewis J, Link C, Rademakers R, Nykjaer A, Petrucelli L Progranulin regulates neuronal outgrowth independent of sortilin. Mol Neurodegener, 2012-07-10;7(0):33. 2012-07-10 [PMID: 22781549] (Human)
• Suh HS, Choi N, Tarassishin L, Lee SC Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12). PLoS ONE, 2012-04-11;7(4):e35115. 2012-04-11 [PMID: 22509390] (Human)
• Al-Ayadhi LY, Mostafa GA Low plasma progranulin levels in children with autism. J Neuroinflammation, 2011-09-05;8(0):111. 2011-09-05 [PMID: 21892962] (Human)
• Diamandis EP, Goodglick L, Planque C, Thornquist MD Pentraxin-3 Is a Novel Biomarker of Lung Carcinoma. Clin. Cancer Res., 2011-01-21;17(8):2395-2399. 2011-01-21 [PMID: 21257721] (Human)
• Carrasquillo MM, Nicholson AM, Finch N, Gibbs JR, Baker M, Rutherford NJ, Hunter TA, DeJesus-Hernandez M, Bisceglio GD, Mackenzie IR, Singleton A, Cookson MR, Crook JE, Dillman A, Hernandez D, Petersen RC, Graff-Radford NR, Younkin SG, Rademakers R Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma. Am. J. Hum. Genet., 2010-11-18;87(6):890-7. 2010-11-18 [PMID: 21087763] (Human)

Bioinformatics

• Gene Symbol: GRN