Human Progranulin DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human Progranulin DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: GRN

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Progranulin DuoSet ELISA, 15 Plate

• Acrogranin
• CLN11
• GEP
• GP88
• granulin precursor
• GRN
• PCDGF
• PEPI
• PGRN
• Proepithelin
• Progranulin

Background

Progranulin, also known as Acrogranin, PCDGF, and Epithelin/Granulin Precursor, is a widely expressed glycoprotein that can undergo proteolysis to generate numerous Granulin peptides. Progranulin plays a role in the regulation of mesothelial differentiation, macrophage development, sexual differentiation of the brain, cartilage proliferation, wound repair, and the development of rheumatoid arthritis and osteoarthritis. It is often upregulated in cancer and contributes to tumor progression. Progranulin upregulation or mutation is associated with several neurological disorders including frontotemporal dementia, Creutzfeldt-Jakob disease, Alzheimer’s disease, and motor neuron disease.

Publications for Progranulin/PGRN (DY2420)(6)

Publications using DY2420

• He, Y;Kaya, I;Shariatgorji, R;Lundkvist, J;Wahlberg, LU;Nilsson, A;Mamula, D;Kehr, J;Zareba-Paslawska, J;Biverstål, H;Chergui, K;Zhang, X;Andren, PE;Svenningsson, P; Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents Nature communications 2023-09-19 [PMID: 37726325] (Human)
• S Miyakawa, H Sakuma, D Warude, S Asanuma, N Arimura, T Yoshihara, D Tavares, A Hata, K Ida, Y Hori, Y Okuzono, S Yamamoto, K Iida, H Shimizu, S Kondo, S Sato Anti-sortilin1 Antibody Up-Regulates Progranulin via Sortilin1 Down-Regulation Frontiers in Neuroscience, 2020-12-15;14(0):586107. 2020-12-15 [PMID: 33384578] (Human)
• L Schulze-Ed, C Dürr, S Öztürk, M Zucknick, A Benner, V Kalter, S Ohl, V Close, P Wuchter, S Stilgenbau, P Lichter, M Seiffert Dissecting the Prognostic Significance and Functional Role of Progranulin in Chronic Lymphocytic Leukemia Cancers (Basel), 2019-06-13;11(6):. 2019-06-13 [PMID: 31200555] (Human)
• Suh H, Lo Y, Choi N, Letendre S, Lee S Insulin-like growth factors and related proteins in plasma and cerebrospinal fluids of HIV-positive individuals. J Neuroinflammation, 2015-04-15;12(0):72. 2015-04-15 [PMID: 25890304] (Human)
• Suh H, Lo Y, Choi N, Letendre S, Lee S Evidence of the innate antiviral and neuroprotective properties of progranulin. PLoS ONE, 2014-05-30;9(5):e98184. 2014-05-30 [PMID: 24878635] (Human)
• Suh HS, Choi N, Tarassishin L, Lee SC Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12). PLoS ONE, 2012-04-11;7(4):e35115. 2012-04-11 [PMID: 22509390] (Human)

FAQs for Progranulin/PGRN (DY2420). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: GRN