Human Myeloperoxidase DuoSet ELISA, 15 Plate

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
Biotin

Order Details

Human Myeloperoxidase DuoSet ELISA, 15 Plate Summary

Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
MPO

Applications/Dilutions

Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DY3174.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Myeloperoxidase DuoSet ELISA, 15 Plate

  • EC 1.11.1
  • EC 1.11.1.7
  • Lactoperoxidase
  • MPO
  • Myeloperoxidase

Background

Myeloperoxidase (MPO) is a heme-containing enzyme belonging to the XPO subfamily of peroxidases. It is an abundant neutrophil and monocyte glycoprotein that catalyzes the hydrogen peroxide dependent formation of hypochlorus acid (HOCl) and other reactive species. Enzymatically active MPO is a disulfide-linked tetramer that contains two heme groups and two copies each of the heavy and light chains. MPO binds Albumin, MMR, Cytokeratin 1 on vascular endothelial cells, HMW Kininogen, and Integrin CD11b/CD18 on neutrophils. These interactions promote MPO clearance, a reduction of nitric oxide and bradykinin levels, reduced vasodilation, and continued neutrophil activation. Neutrophil MPO is stored in cytoplasmic azurophilic granules. Upon cellular activation and degranulation, MPO is delivered into phagosomes where it is required for the killing of phagocytosed bacteria. Activated neutrophils also release granule contents extracellularly. Elevated plasma MPO levels have been associated with a variety of clinical conditions including systemic inflammation, eclampsia, risk of cardiovascular events, vascular endothelial dysfunction, severity of multiple sclerosis, and prospective mortality and oxidative stress during hemodialysis.

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Applications: ELISA

Publications for Myeloperoxidase/MPO (DY3174)(8)

We have publications tested in 1 confirmed species: Human.


Filter By Application
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Filter By Species
Human
(8)
All Species
Showing Publications 1 - 8 of 8.
Publications using DY3174 Applications Species
RD Williamson, FP McCarthy, LC Kenny, CM McCarthy Activation of a TLR9 mediated innate immune response in preeclampsia Sci Rep, 2019;9(1):5920. 2019 [PMID: 30976066] (Human) Human
HM Alyami, LS Finoti, HS Teixeira, A Aljefri, DF Kinane, MR Benakanake Role of NOD1/NOD2 receptors in Fusobacterium nucleatum mediated NETosis Microb. Pathog., 2019;0(0):. 2019 [PMID: 30940608] (Human) Human
D Emal, E Rampanelli, N Claessen, FJ Bemelman, JC Leemans, S Florquin, MC Dessing Calcineurin inhibitor Tacrolimus impairs host immune response against urinary tract infection Sci Rep, 2019;9(1):106. 2019 [PMID: 30643171] (Human) Human
T Barliya, R Dardik, Y Nisgav, M Dachbash, D Gaton, G Kenet, R Ehrlich, D Weinberger, T Livnat Possible involvement of NETosis in inflammatory processes in the eye: Evidence from a small cohort of patients Mol. Vis., 2017;23(0):922-932. 2017 [PMID: 29296072] (Human) Human
L Rocha-Penh, M Caldeira-D, JE Tanus-Sant, R de Carvalh, VC Sandrim Myeloperoxidase in Hypertensive Disorders of Pregnancy and Its Relation With Nitric Oxide Hypertension, 2017;0(0):. 2017 [PMID: 28461600] (Human) Human
Swimming Motility Mediates the Formation of Neutrophil Extracellular Traps Induced by Flagellated Pseudomonas aeruginosa PLoS Pathog., 2016;12(11):e1005987. 2016 [PMID: 27855208] (Human) Human
Koepke J, Dresel M, Schmid S, Greulich T, Beutel B, Schmeck B, Vogelmeier C, Janciauskiene S, Koczulla A Therapy with plasma purified alpha1-antitrypsin (Prolastin(R)) induces time-dependent changes in plasma levels of MMP-9 and MPO. PLoS ONE, 2015;10(0):. 2015 [PMID: 25635861] (Human) Human
Yoo D, Winn M, Pang L, Moskowitz S, Malech H, Leto T, Rada B Release of cystic fibrosis airway inflammatory markers from Pseudomonas aeruginosa-stimulated human neutrophils involves NADPH oxidase-dependent extracellular DNA trap formation. J Immunol, 2014;192(10):4728-38. 2014 [PMID: 24740504] (Human) Human

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Product General Protocols

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FAQs for Myeloperoxidase/MPO (DY3174). (Showing 1 - 1 of 1 FAQs).

  1. wondering what the difference is between your quantikine and duo set elisas?
    • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Other Available Formats

Biotin DY3174

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Bioinformatics

Gene Symbol MPO