Human Lipocalin-2/NGAL DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human Lipocalin-2/NGAL DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: LCN2

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Lipocalin-2/NGAL DuoSet ELISA, 15 Plate

• 24p3
• 25 kDa alpha-2-microglobulin-related subunit of MMP-9
• HNL
• LCN2
• lipocalin 2 (oncogene 24p3)
• lipocalin 2
• Lipocalin2
• Lipocalin-2
• migration-stimulating factor inhibitor
• MSFI
• neutrophil gelatinase-associated lipocalin
• NGAL
• NGALlipocalin-2
• Oncogene 24p3
• p25
• Siderocalin
• Uterocalin

Background

The Lipocalin family comprises a diverse group of mostly secreted soluble proteins that bind hydrophobic ligands and act as transporters, carrying small molecules to specific cells. Lipocalins are related by possessing an 8-stranded beta-barrel structure. Lipocalin-1, also named tear lipocalin (TL), von Ebners gland protein (VEG) and tear pre-albumin, binds a large number of hydrophobic molecules and exhibits cysteine proteinase inhibitor and endonuclear activities. Lipocalin-2, also known as neutrophil gelatinase-associated lipocalin (NGAL), is a component of granules in neutrophils from tissues that are normally exposed to microorganisms and is upregulated during inflammation. Lipocalin-2 can form homodimers and can heterodimerize with the neutrophil gelatinase MMP-9.

Publications for Lipocalin-2/NGAL (DY1757)(39)

Publications using DY1757

• Somova, M;Simm, S;Ehrhardt, J;Schoon, J;Burchardt, M;Pinto, PC; SARS-CoV-2 Spike Protein Amplifies the Immunogenicity of Healthy Renal Epithelium in the Presence of Renal Cell Carcinoma Cells 2024-12-10 [PMID: 39768130] (ELISA, Human)
• Hanford, HE;Price, CTD;Uriarte, S;Abu Kwaik, Y; Inhibition and evasion of neutrophil microbicidal responses by Legionella longbeachae mBio 2024-12-16 [PMID: 39679679] (Human)
• Williams, ME;Asia, LK;Lindeque, Z;Jansen van Vuren, E; The association between HIV-1 Tat and Vif amino acid sequence variation, inflammation and Trp-Kyn metabolism: an exploratory investigation BMC infectious diseases 2024-09-09 [PMID: 39251983] (Human)
• Herfindal, AM;Nilsen, M;Aspholm, TE;Schultz, GIG;Valeur, J;Rudi, K;Thoresen, M;Lundin, KEA;Henriksen, C;Bøhn, SK; Effects of fructan and gluten on gut microbiota in individuals with self-reported non-celiac gluten/wheat sensitivity-a randomised controlled crossover trial BMC medicine 2024-09-04 [PMID: 39227818] (Human)
• Cho, HY;Lee, JE;Park, KH;Choi, BY;Lee, MJ;Jeong, DE;Shin, S; Identification and characterization of plasma proteins associated with intra-amniotic inflammation and/or infection in women with preterm labor. Scientific reports 2024-06-25 [PMID: 38918423] (Human)
• de Rooij, ENM;Hoogeveen, EK;Romijn, FPHTM;van der Kooy, SW;Veighey, KV;Dekker, FW;van Kooten, C;Cobbaert, CM;de Fijter, JW; Urinary beta-2 microglobulin increases whereas TIMP-2 and IGFBP7 decline after unilateral nephrectomy in healthy kidney donors Scientific reports 2024-06-05 [PMID: 38839764] (Human)
• Xu, S;Hultström, M;Larsson, A;Lipcsey, M;Lindskog, C;Bülow, S;Frithiof, R;Venge, P; The Human Phospholipase B-II Precursor (HPLBII-P) in Urine as a Novel Biomarker of Glomerular Activity in COVID-19 and Diabetes Mellitus Journal of clinical medicine 2024-04-26 [PMID: 38731071] (Human)
• Grannes, H;Ueland, T;Simeone, P;Liani, R;Guagnano, MT;Aukrust, P;Michelsen, AE;Birkeland, K;di Castelnuovo, A;Cipollone, F;Consoli, A;Halvorsen, B;Gregersen, I;Santilli, F; Liraglutide and not lifestyle intervention reduces soluble CD163 after comparable weight loss in obese participants with prediabetes or type 2 diabetes mellitus Cardiovascular diabetology 2024-04-29 [PMID: 38685051] (Human)
• Nagayama, I;Takayanagi, K;Nagata, D;Hasegawa, H;Maeshima, A; Potential Utility of Urinary Follistatin as a Non-Invasive Indicator of Acute Tubular Damage in Patients with Acute Kidney Injury Cells 2024-03-16 [PMID: 38534369] (Human)
• Ramakrishnan, G;Young, MK;Nayak, U;Rigo, I;Marrs, AS;Gilchrist, CA;Behm, BW;Madden, GR;Petri, WA; Systemic neutrophil degranulation and emergency granulopoiesis in patients with Clostridioides difficile infection Anaerobe 2024-03-19 [PMID: 38514010] (Human)
• Paparella, R;Ferraguti, G;Fiore, M;Menghi, M;Micangeli, G;Tarani, F;Ligotino, A;Messina, MP;Ceccanti, M;Minni, A;Barbato, C;Lucarelli, M;Tarani, L;Petrella, C; Serum Lipocalin-2 Levels as a Biomarker in Pre- and Post-Pubertal Klinefelter Syndrome Patients: A Pilot Study International journal of molecular sciences 2024-02-12 [PMID: 38396890] (Human)
• Lablad, Y;Vanhomwegen, C;De Prez, E;Antoine, MH;Hasan, S;Baudoux, T;Nortier, J; Longitudinal Follow-Up of Serum and Urine Biomarkers Indicative of COVID-19-Associated Acute Kidney Injury: Diagnostic and Prognostic Impacts International journal of molecular sciences 2023-11-18 [PMID: 38003685] (Human)
• Ravn, EJ;Hasific, S;Thomassen, M;Hjortebjerg, R;Bach Laursen, K;Diederichsen, A;Bistrup, C;Øvrehus, KA; Intravenous versus oral hydration to reduce the risk of postcontrast acute kidney injury after intravenous contrast-enhanced CT in patients with severe chronic kidney disease (ENRICH): a study protocol for a single-centre, parallel-group, open-labelled non-inferiority randomised controlled trial in Denmark BMJ open 2023-09-12 [PMID: 37699636] (Human)
• Goulet, N;Tetzlaff, EJ;Morin, R;Mauger, JF;Amaratunga, R;Kenny, GP;Imbeault, P; No impact of a high-fat meal coupled with intermittent hypoxemia on acute kidney injury biomarkers in adults with and without obstructive sleep apnea Physiological reports 2023-09-01 [PMID: 37653582] (Human)
• Z Cao, IJ Burvenich, K Zhao, C Senko, J Glab, R Fogliaro, Z Liu, I Jose, H Puthalakat, NJ Hoogenraad, LD Osellame, AM Scott Identification of Potential Biomarkers for Cancer Cachexia and Anti-Fn14 Therapy Cancers, 2022-11-10;14(22):. 2022-11-10 [PMID: 36428623] (Human)
• PJW Naudé, C Pariante, N Hoffman, SM Koopowitz, KA Donald, HJ Zar, DJ Stein Antenatal maternal depression, early life inflammation and neurodevelopment in a South African birth cohort Brain, Behavior, and Immunity, 2022-07-06;105(0):160-168. 2022-07-06 [PMID: 35803482] (Human)
• HM Demerdash, AA Sabry, OE Arida Impact of Zinc to Copper Ratio and Lipocalin 2 in Obese Patients Undergoing Sleeve Gastrectomy Oncogene, 2022-06-10;2022(0):9278531. 2022-06-10 [PMID: 35722455] (Human)
• S Macdonald, E Bosio, NI Shapiro, L Balmer, S Burrows, M Hibbs, T Jowitt, L Smart, G Arendts, D Fatovich No association between intravenous fluid volume and endothelial glycocalyx shedding in patients undergoing resuscitation for sepsis in the emergency department Scientific Reports, 2022-05-24;12(1):8733. 2022-05-24 [PMID: 35610344] (Human)
• JH Kim, H Lee, J Oh, K Suk, BY Chun Increased Plasma Lipocalin-2 Levels in Patients with Myelin Oligodendrocyte Glycoprotein-IgG-Positive Optic Neuritis Journal of Clinical Medicine, 2022-05-07;11(9):. 2022-05-07 [PMID: 35566760] (Human)
• M Lipcsey, M Bergquist, R Sirén, A Larsson, F Huss, J Pravda, M Furebring, J Sjölin, H Janols Urine Hydrogen Peroxide Levels and Their Relation to Outcome in Patients with Sepsis, Septic Shock, and Major Burn Injury Biomedicines, 2022-04-05;10(4):. 2022-04-05 [PMID: 35453598] (Human)
• ACC Loureiro, GF Nocrato, ALL Correia, RS de Matos, JCCN Filho, EF Daher, FHM Pinto, AC de Oliveir, VM Ceccatto, RS Fortunato, DP de Carvalh Serum and Urinary Neutrophil Gelatinase-Associated Lipocalin Are Not Associated With Serum Redox Parameters in Amateur Athletes After an Ultramarathon Frontiers in Physiology, 2022-03-17;13(0):811514. 2022-03-17 [PMID: 35370771] (Human)
• S Hong, KH Park, YE Lee, JE Lee, YM Kim, E Joo, I Cho Antibody microarray analysis of amniotic fluid proteomes in women with cervical insufficiency and short cervix, and their association with pregnancy latency length PLoS ONE, 2022-02-07;17(2):e0263586. 2022-02-07 [PMID: 35130326] (Human)
• Ingunn Bakke, Gunnar Andreas Walaas, Torunn Bruland, Elin Synnøve Røyset, Atle van Beelen Granlund, Celia Escudero-Hernández et al. Mucosal and faecal neutrophil gelatinase-associated lipocalin as potential biomarkers for collagenous colitis Journal of Gastroenterology 2021-10-01 [PMID: 34414506]
• A Gradin, H Andersson, T Luther, SB Anderberg, S Rubertsson, M Lipcsey, M Åberg, A Larsson, R Frithiof, M Hultström Urinary cytokines correlate with acute kidney injury in critically ill COVID-19 patients Cytokine, 2021-05-24;146(0):155589. 2021-05-24 [PMID: 34161857] (Human)
• B Olson, X Zhu, MA Norgard, PR Levasseur, JT Butler, A Buenafe, KG Burfeind, KA Michaelis, KR Pelz, H Mendez, J Edwards, SM Krasnow, AJ Grossberg, DL Marks Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia Nature Communications, 2021-04-06;12(1):2057. 2021-04-06 [PMID: 33824339] (Human)
• C Veraar, J Kliman, A Benazzo, F Oberndorfe, M Laggner, P Hacker, T Raunegger, S Janik, P Jaksch, W Klepetko, HJ Ankersmit, B Moser Potential novel biomarkers for chronic lung allograft dysfunction and azithromycin responsive allograft dysfunction Scientific Reports, 2021-03-24;11(1):6799. 2021-03-24 [PMID: 33762606] (Human)
• L Kang, S Smith, C Wang Stabilization of surface-bound antibodies for ELISA based on a reversable zeolitic imidazolate framework-8 coating Journal of colloid and interface science, 2020-12-24;588(0):101-109. 2020-12-24 [PMID: 33388576] (Human)
• HK Pihlstrøm, T Ueland, AE Michelsen, P Aukrust, F Gatti, C Hammarströ, M Kasprzycka, J Wang, G Haraldsen, G Mjøen, DO Dahle, K Midtvedt, IA Eide, A Hartmann, H Holdaas Exploring the potential effect of paricalcitol on markers of inflammation in de novo renal transplant recipients PLoS ONE, 2020-12-16;15(12):e0243759. 2020-12-16 [PMID: 33326471] (Human)
• M Bergquist, L Samuelsson, A Larsson, J Tydén, J Johansson, M Lipcsey TNFR1, TNFR2, neutrophil gelatinase-associated lipocalin and heparin binding protein in identifying sepsis and predicting outcome in an intensive care cohort Scientific Reports, 2020-09-18;10(1):15350. 2020-09-18 [PMID: 32948801] (Human)
• B Cuffaro, ALW Assohoun, D Boutillier, L Súkeníková, J Desramaut, S Boudebbouz, S Salomé-Des, J Hrdý, AJ Waligora-D, E Maguin, C Grangette In Vitro Characterization of Gut Microbiota-Derived Commensal Strains: Selection of Parabacteroides distasonis Strains Alleviating TNBS-Induced Colitis in Mice Cells, 2020-09-16;9(9):. 2020-09-16 [PMID: 32947881] (Human)
• A Stanton, C Mowbray, M Lanz, K Brown, P Hilton, A Tyson-Capp, RS Pickard, ASM Ali, J Hall Topical Estrogen Treatment Augments the Vaginal Response to Escherichia coli Flagellin Sci Rep, 2020-05-21;10(1):8473. 2020-05-21 [PMID: 32439855] (Human)
• J Merkle, A Daka, AC Deppe, T Wahlers, A Paunel-Gör High levels of cell-free DNA accurately predict late acute kidney injury in patients after cardiac surgery PLoS ONE, 2019-06-18;14(6):e0218548. 2019-06-18 [PMID: 31211810] (Human)
• YT Kang, WC Hsu, CH Wu, IL Hsin, PR Wu, KT Yeh, JL Ko Metformin alleviates nickel-induced autophagy and apoptosis via inhibition of hexokinase-2, activating lipocalin-2, in human bronchial epithelial cells Oncotarget, 2017-11-06;8(62):105536-105552. 2017-11-06 [PMID: 29285270] (Human)
• Microbiota-inducible Innate Immune, Siderophore Binding Protein Lipocalin 2 is Critical for Intestinal Homeostasis Cell Mol Gastroenterol Hepatol, 2016-07-01;2(4):482-498.e6. 2016-07-01 [PMID: 27458605] (Human)
• Silk-based blood stabilization for diagnostics Proc Natl Acad Sci USA, 2016-05-09;113(21):5892-7. 2016-05-09 [PMID: 27162330] (Human)
• Zager R, Johnson A, Frostad K Rapid renal alpha-1 antitrypsin gene induction in experimental and clinical acute kidney injury. PLoS ONE, 2014-05-21;9(5):e98380. 2014-05-21 [PMID: 24848503] (Human)
• Zughaier , Susu M, Kandler , Justin L, Shafer , William Neisseria gonorrhoeae modulates iron-limiting innate immune defenses in macrophages. PLoS ONE, 2014-01-28;9(1):e87688. 2014-01-28 [PMID: 24489950] (Human)
• Paton C, Rogowski M, Kozimor A, Stevenson J, Chang H, Cooper J Lipocalin-2 increases fat oxidation in vitro and is correlated with energy expenditure in normal weight but not obese women. Obesity (Silver Spring), 2013-07-29;21(12):E640-8. 2013-07-29 [PMID: 23640923] (Human)
• Alvarez J, Zughaier S, Law J, Hao L, Wasse H, Ziegler T, Tangpricha V Effects of high-dose cholecalciferol on serum markers of inflammation and immunity in patients with early chronic kidney disease. Eur J Clin Nutr, 2013-01-30;67(3):264-9. 2013-01-30 [PMID: 23361158] (Human)

FAQs for Lipocalin-2/NGAL (DY1757). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: LCN2