Human IL-6 Quantikine ELISA Kit

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Product Details

Summary
Reactivity HuSpecies Glossary
Conjugate
HRP

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Human IL-6 Quantikine ELISA Kit Summary

Background
The Quantikine Human IL-6 Immunoassay is a 4.5 hour solid phase immunoassay designed to measure human IL-6 in cell culture supernates, serum, plasma, and urine. It contains recombinant human IL-6 and antibodies raised against the recombinant protein. Natural human IL-6 showed dose-response curves that were parallel to the standard curves obtained using the Quantikine kit standards, indicating that this kit can be used to determine relative levels of natural human IL-6.
Specificity
Natural and recombinant human IL-6.
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details

Applications/Dilutions

Application Notes
Interference observed with 1 or more available related molecules.
Publications
Read Publications using
D6050B in the following applications:

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IL-6 Quantikine ELISA Kit

  • B-cell differentiation factor
  • B-cell stimulatory factor 2
  • BSF2
  • BSF-2
  • CDF
  • CTL differentiation factor
  • HSF
  • hybridoma growth factor
  • IFNB2
  • IFN-beta-2
  • IL6
  • IL-6
  • Interferon beta-2
  • interleukin 6 (interferon, beta 2)
  • interleukin BSF-2
  • interleukin-6
  • MGI-2A

Background

IL-6 (Interleukin-6) is a pleiotropic cytokine that acts in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. It contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis. IL-6 signals through a receptor complex of IL-6 R alpha and gp130. gp130 is also a component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6 R alpha are generated by both alternative splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6 R alpha.

Publications for IL-6 (D6050B)(753)

We have publications tested in 10 confirmed species: Human, Mouse, Rat, Porcine, Primate - Chlorocebus aethiops (African Green Monkey), Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque), Primate - Macaca mulatta (Rhesus Macaque), Primate - Papio cynocephalus (Yellow Baboon), Rabbit, Xenograft.

We have publications tested in 1 application: ELISA Capture.


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ELISA Capture
(5)
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Human
(713)
Mouse
(17)
Rat
(5)
Porcine
(1)
Primate - Chlorocebus aethiops (African Green Monkey)
(1)
Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
(2)
Primate - Macaca mulatta (Rhesus Macaque)
(7)
Primate - Papio cynocephalus (Yellow Baboon)
(1)
Rabbit
(2)
Xenograft
(3)
All Species
Showing Publications 1 - 10 of 753. Show All 753 Publications.
Publications using D6050B Applications Species
Park, YJ;Acosta, D;Rubel Hoq, M;Khurana, S;Golding, H;Zaitseva, M; Pyrogenic and inflammatory mediators are produced by polarized M1 and M2 macrophages activated with D-dimer and SARS-CoV-2 spike immune complexes Cytokine 2024-01-01 [PMID: 38041875] (Human) Human
Shang, J;Hines, S;Makarczyk, MJ;Lin, H;Hogan, MV;Yan, A; Influence of the Synthetic Cannabinoid Agonist on Normal and Inflamed Cartilage: An In Vitro Study Biomolecules 2023-10-10 [PMID: 37892184] (Human) Human
Sinha, I;Zhu, J;Sinha, R; Selective Impact of Selenium Compounds on Two Cytokine Storm Players Journal of personalized medicine 2023-09-30 [PMID: 37888066] (Human) Human
Pleros, C;Adamidis, K;Kantartzi, K;Griveas, I;Baltsavia, I;Moustakas, A;Kalliaropoulos, A;Fraggedaki, E;Petra, C;Damianakis, N;Mentis, A;Drosataki, E;Petrakis, I;Passadakis, P;Panagopoulos, P;Stylianou, K;Panagoutsos, S; Dialysis Patients Respond Adequately to Influenza Vaccination Irrespective of Dialysis Modality and Chronic Inflammation Journal of clinical medicine 2023-09-26 [PMID: 37834849] (Human) Human
Vega-Jasso, AL;Amezcua-Guerra, LM;González-Pacheco, H;Sandoval-Zárate, J;González-Díaz, CA;Escobar-Alvarado, J;Manzano-Luna, JD;Brianza-Padilla, M; Adipokines and Inflammatory Markers in Acute Myocardial Infarction Patients with and without Obstructive Sleep Apnea: A Comparative Analysis International journal of molecular sciences 2023-09-28 [PMID: 37834123] (Human) Human
Ryoo, GH;Kim, GJ;Han, AR;Jin, CH;Lee, H;Nam, JW;Choi, H;Jung, CH; Antimetastatic activity of seongsanamide B in ?-irradiated human lung cancer Heliyon 2023-09-01 [PMID: 37809399] (Human) Human
Tomaszewski, M;Mertowska, P;Janczewska, M;Stycze?, A;Mertowski, S;Jonas, K;Grywalska, E;Kope?, G; In the Search for Biomarkers of Pulmonary Arterial Hypertension, Are Cytokines IL-2, IL-4, IL-6, IL-10, and IFN-Gamma the Right Indicators to Use? International journal of molecular sciences 2023-09-05 [PMID: 37761997] (Human) Human
Aboussekhra, A;Alraouji, NN;Al-Mohanna, FH;Al-Khalaf, H; Ionizing radiation normalizes the features of active breast cancer stromal fibroblasts and suppresses their paracrine pro-carcinogenic effects Translational oncology 2023-09-04 [PMID: 37672859] (Human) Human
Han, SH;Lee, HD;Lee, S;Lee, AY; Taraxacum coreanum Nakai extract attenuates lipopolysaccharide-induced inflammatory responses and intestinal barrier dysfunction in Caco-2 cells Journal of ethnopharmacology 2023-09-03 [PMID: 37660957] (Human) Human
Buczy?ska, A;Sidorkiewicz, I;Ko?ciuszko, M;Adamska, A;Siewko, K;Dzi?cio?, J;Szumowski, P;My?liwiec, J;Szelachowska, M;Pop?awska-Kita, A;Kr?towski, A; Clinical significance of oxidative stress markers as angioinvasion and metastasis indicators in papillary thyroid cancer Scientific reports 2023-08-22 [PMID: 37608150] (Human) Human