TLR2 is a member of the broad family of Toll-like receptors (TLR) that play an important role in pathogen recognition and innate immunity. TLRs, like other pattern recognition receptors (PRRs), recognize endogenous ligands released during cell or tissue damage (DAMPs) as well as exogenous, pathogen associated ligands from bacteria or viruses (PAMPs). Upon recognition of a specific ligand, PRRs activate host defense processes including cytokine and inflammatory mediator secretion, and innate immune cell activation and proliferation. TLR2 recognizes the bacterial cell wall component, peptidoglycan. Recent Studies
- A TLR2 antibody expression profiling study published by Palladino et al uncovered detailed profiles for over a dozen TLR family members in rat male reproductive tract organs and tissues1.
- A Dutch research group used a TLR2 antibody to create similar expression profiles in human multiple myeloma (MM) cells2. They found a broad range of TLR expression, along with some disparity between gene and protein expression profiles, helping to explain the propensity of MM cells to respond to tumor-induced triggers.
- Recent studies have examined the role of miRNAs in modulating TLR induced inflammation. One such study using the TLR2 antibody demonstrated that the microRNA miR-19 acts as a negative regulator or TLR2 mediated IL-6 production3.
- Wong et al used an anti-TLR2 antibody in western blot and flow cytometry to measure the impact of TLR2 signaling on downstream immune responses in human eosinophils. They found interesting links between microbial infection and allergic inflammation responses4.
- A TLR2 antibody was also employed to confirm results of a microarray analysis performed by the Deretic lab at the University of New Mexico to assess cystic fibrosis-relevant signaling pathways activated in response to bacterial lipotoxins derived from the mucoid Pseudomonas aeruginosa5.
Novus Biologicals offers TLR2 reagents for your research needs including: