Human FGF-21 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human FGF-21 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: FGF21

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human FGF-21 DuoSet ELISA, 15 Plate

• FGF21
• FGF-21
• fibroblast growth factor 21

Background

FGF-21 (Fibroblast Growth Factor 21) is a member of an FGF subfamily that also includes FGF-19 and FGF-23. FGF-19 subfamily members lack a heparin binding domain, enabling them to freely circulate as endocrine factors and diffuse within tissues. FGF-21 signals through Klotho beta in complex with FGF receptors. It regulates cellular metabolism including glucose uptake in adipocytes and cellular sensitivity to insulin. It is basally expressed in the pancreas, thymus, liver, and adipose tissue and is upregulated in liver, muscle, and fat in obesity and diabetes. FGF-21 also plays a role in cell survival and proliferation, mesenchymal stem cell differentiation, circadian rhythm, and controlling reproductive capacity.

Publications for FGF-21 (DY2539)(8)

Publications using DY2539

• Livshits, G;Tarabeih, N;Kalinkovich, A;Shalata, A;Ashkenazi, S; Metabolic and Inflammatory Biomarkers Predicting Sarcopenic Obesity and Cardiometabolic Risk in Arab Women: A Cross-Sectional Study International journal of molecular sciences 2025-06-13 [PMID: 40565161] (Human)
• Huijbers, A;Korzilius, JW;Morsche, RT;van der Graaf, M;Wanten, GJA; Intestinal failure-associated steatosis and fibroblast growth factor 21 plasma levels among adult chronic intestinal failure patients Clinical nutrition ESPEN 2025-04-26 [PMID: 40294745] (Human)
• Lopez-Pascual, A;Santamaria, E;Ardaiz, N;Uriarte, I;Palmer, T;Graham, AR;Gomar, C;Barbero, RC;Latasa, MU;Arechederra, M;Urman, JM;Berasain, C;Fontanellas, A;Del Rio, CL;Fernandez-Barrena, MG;Martini, PGV;Schultz, JR;Berraondo, P;Avila, MA; FGF21 and APOA1 mRNA-based therapies for the treatment of experimental acute pancreatitis Journal of translational medicine 2025-01-27 [PMID: 39871339] (Human)
• Castañé, H;Jiménez-Franco, A;Hernández-Aguilera, A;Martínez-Navidad, C;Cambra-Cortés, V;Onoiu, AI;Jiménez-Aguilar, JM;París, M;Hernández, M;Parada, D;Guilarte, C;Zorzano, A;Hernández-Alvarez, MI;Camps, J;Joven, J; Multi-omics profiling reveals altered mitochondrial metabolism in adipose tissue from patients with metabolic dysfunction-associated steatohepatitis EBioMedicine 2025-01-01 [PMID: 39731853] (Human)
• JY Lu, HY Ou, CZ Wu, CY Yang, JY Jiang, CH Lu, YD Jiang, TJ Chang, YC Chang, ML Hsieh, WC Wu, HY Li, YF Du, CH Lin, HC Hung, KJ Tien, NC Yeh, SY Lee, HI Yu, LM Chuang A randomized trial on the effect of transcutaneous electrical nerve stimulator on glycemic control in patients with type 2 diabetes Scientific Reports, 2023-02-15;13(1):2662. 2023-02-15 [PMID: 36792682] (Human)
• G Fiorilli, F Quinzi, A Buonsenso, G Casazza, L Manni, A Parisi, A Di Costanz, G Calcagno, M Soligo, A di Cagno A Single Session of Whole-Body Electromyostimulation Increases Muscle Strength, Endurance and proNGF in Early Parkinson Patients International Journal of Environmental Research and Public Health, 2021-05-20;18(10):. 2021-05-20 [PMID: 34065571] (Human)
• PK Fazeli, MA Bredella, OG Pachon-Peñ, W Zhao, X Zhang, AT Faje, M Resulaj, SP Polineni, TM Holmes, H Lee, EK O'Donnell, OA MacDougald, MC Horowitz, CJ Rosen, A Klibanski The dynamics of human bone marrow adipose tissue in response to feeding and fasting JCI Insight, 2021-06-22;0(0):. 2021-06-22 [PMID: 33974568] (Human)
• AL Magno, LY Herat, MG Kiuchi, MP Schlaich, NC Ward, VB Matthews The Influence of Hypertensive Therapies on Circulating Factors: Clinical Implications for SCFAs, FGF21, TNFSF14 and TNF-&alpha Journal of Clinical Medicine, 2020-08-26;9(9):. 2020-08-26 [PMID: 32858953] (Human)

FAQs for FGF-21 (DY2539). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: FGF21