Human CXCL9/MIG DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human CXCL9/MIG DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: CXCL9

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human CXCL9/MIG DuoSet ELISA, 15 Plate

• chemokine (C-X-C motif) ligand 9
• CMK
• crg-10
• C-X-C motif chemokine 9
• CXCL9
• Gamma-interferon-induced monokine
• Humig
• MIG
• MIGSmall-inducible cytokine B9
• monokine induced by gamma interferon
• SCYB9Monokine induced by interferon-gamma

Background

CXCL9, also known as MIG, is a chemokine that is induced in macrophages and in CNS glial cells in response to IFN-gamma. CXCL9 signals through CXCR3 to induce the chemoattraction of activated T cells and tumor-infiltrating lymphocytes.

Publications for CXCL9/MIG (DY392)(26)

Publications using DY392

• Green, HLH;Sum, H;Sinha, P;Visnagri, A;Lee, SH;Baffour-Kyei, A;Lee, H;Santos, F;Theofilatos, K;Brewer, AC; TET2 has endothelial-specific roles in interferon responses that are dysregulated by hyperglycaemia in vitro and in vivo The Journal of biological chemistry 2025-07-25 [PMID: 40716745] (Human)
• Tinel, C;Sauvaget, V;Aouni, L;Lamarthée, B;Terzi, F;Legendre, C;Rabant, M;Anglicheau, D; Transforming kidney transplant monitoring with urine CXCL9 and CXCL10: practical clinical implementation Scientific reports 2024-09-02 [PMID: 39223175] (Human)
• Cherpaz, M;Meugnier, E;Seillier, G;Pozzi, M;Pierrard, R;Leboube, S;Farhat, F;Vola, M;Obadia, JF;Amaz, C;Chalabreysse, L;May, C;Chanon, S;Brun, C;Givre, L;Bidaux, G;Mewton, N;Derumeaux, G;Bergerot, C;Paillard, M;Thibault, H; Myocardial transcriptomic analysis of diabetic patients with aortic stenosis: key role for mitochondrial calcium signaling Cardiovascular diabetology 2024-07-08 [PMID: 38978010] (Human)
• T Koudstaal, D van Uden, JAC van Hulst, P Heukels, IM Bergen, LW Geenen, VJM Baggen, AE van den Bo, LM van den To, PP Chandoesin, M Kool, E Boersma, RW Hendriks, KA Boomars Plasma markers in pulmonary hypertension subgroups correlate with patient survival Respiratory Research, 2021-05-04;22(1):137. 2021-05-04 [PMID: 33947407] (Human)
• GK Vasileiadi, AC Lundell, Y Zhang, K Andersson, I Gjertsson, A Rudin, C Maglio Adipocytokines in Untreated Newly Diagnosed Rheumatoid Arthritis: Association with Circulating Chemokines and Markers of Inflammation Biomolecules, 2021-02-21;11(2):. 2021-02-21 [PMID: 33669910] (Human)
• A Radujkovic, T Boch, F Nolte, D Nowak, C Kunz, A Gieffers, C Müller-Tid, P Dreger, WK Hofmann, T Luft Clinical Response to the CD95-Ligand Inhibitor Asunercept Is Defined by a Pro-Inflammatory Serum Cytokine Profile Cancers, 2020-12-08;12(12):. 2020-12-08 [PMID: 33302451] (Human)
• A Radujkovic, L Kordelas, R Bogdanov, C Müller-Tid, DW Beelen, P Dreger, T Luft Interleukin-18 and Hematopoietic Recovery after Allogeneic Stem Cell Transplantation Cancers (Basel), 2020-09-28;12(10):. 2020-09-28 [PMID: 32998441] (Human)
• JA Woznicki, P Flood, M Bustamante, P Stamou, G Moloney, A Fanning, SA Zulquernai, J McCarthy, F Shanahan, S Melgar, K Nally Human BCL-G regulates secretion of inflammatory chemokines but is dispensable for induction of apoptosis by IFN-gamma and TNF-alpha in intestinal epithelial cells Cell Death Dis, 2020-01-27;11(1):68. 2020-01-27 [PMID: 31988296] (Human)
• G Prencipe, C Bracaglia, I Caiello, A Pascarella, P Francalanc, M Pardeo, A Meneghel, G Martini, MN Rossi, A Insalaco, G Marucci, V Nobili, M Spada, F Zulian, F De Benedet The interferon-gamma pathway is selectively up-regulated in the liver of patients with secondary hemophagocytic lymphohistiocytosis PLoS ONE, 2019-12-17;14(12):e0226043. 2019-12-17 [PMID: 31846457] (Human)
• Y Hosokawa, I Hosokawa, K Ozaki, T Matsuo IL-27 Modulates Chemokine Production in TNF-? -Stimulated Human Oral Epithelial Cells Cell. Physiol. Biochem., 2017-10-05;43(3):1198-1206. 2017-10-05 [PMID: 28977795] (Human)
• K Fujii, Y Miyahara, N Harada, D Muraoka, M Komura, R Yamaguchi, H Yagita, J Nakamura, S Sugino, S Okumura, S Imoto, S Miyano, H Shiku Identification of an immunogenic neo-epitope encoded by mouse sarcoma using CXCR3 ligand mRNAs as sensors Oncoimmunology, 2017-03-20;6(5):e1306617. 2017-03-20 [PMID: 28638727] (Human)
• C Windmüller, D Zech, S Avril, M Boxberg, T Dawidek, B Schmalfeld, M Schmitt, M Kiechle, H Bronger CXCR3 mediates ascites-directed tumor cell migration and predicts poor outcome in ovarian cancer patients Oncogenesis, 2017-05-15;6(5):e331. 2017-05-15 [PMID: 28504691] (Human)
• JP Strassner, M Rashighi, M Ahmed Refa, JM Richmond, JE Harris Suction blistering the lesional skin of vitiligo patients reveals useful biomarkers of disease activity J. Am. Acad. Dermatol, 2017-03-01;0(0):. 2017-03-01 [PMID: 28259440] (Human)
• CXCL9 and CXCL10 predict survival and are regulated by cyclooxygenase inhibition in advanced serous ovarian cancer Br J Cancer, 2016-08-04;0(0):. 2016-08-04 [PMID: 27490802] (Human)
• Nagarsheth N, Peng D, Kryczek I, Wu K, Li W, Zhao E, Zhao L, Wei S, Frankel T, Vatan L, Szeliga W, Dou Y, Owens S, Marquez V, Tao K, Huang E, Wang G, Zou W PRC2 Epigenetically Silences Th1-Type Chemokines to Suppress Effector T-Cell Trafficking in Colon Cancer. Cancer Res, 2015-11-13;76(2):275-82. 2015-11-13 [PMID: 26567139] (Human)
• Fenwick P, Macedo P, Kilty I, Barnes P, Donnelly L Effect of JAK Inhibitors on Release of CXCL9, CXCL10 and CXCL11 from Human Airway Epithelial Cells. PLoS ONE, 2015-06-19;10(6):e0128757. 2015-06-19 [PMID: 26090665] (Human)
• Maddur M, Sharma M, Hegde P, Stephen-Victor E, Pulendran B, Kaveri S, Bayry J Human B cells induce dendritic cell maturation and favour Th2 polarization by inducing OX-40 ligand. Nat Commun, 2014-06-09;5(0):4092. 2014-06-09 [PMID: 24910129] (Human)
• Manousou P, Kolios G, Drygiannakis I, Koulentaki M, Pyrovolaki K, Voumvouraki A, Notas G, Bourikas L, Papadaki H, Kouroumalis E CXCR3 axis in patients with primary biliary cirrhosis: a possible novel mechanism of the effect of ursodeoxycholic acid. Clin Exp Immunol, 2013-04-01;172(1):9-15. 2013-04-01 [PMID: 23480180] (Human)
• Brietzke E, Kauer-Sant'Anna M, Teixeira AL, Kapczinski F Abnormalities in serum chemokine levels in euthymic patients with bipolar disorder. Brain Behav. Immun., 2009-05-04;23(8):1079-82. 2009-05-04 [PMID: 19406226] (Human)
• Teixeira AL, Reis HJ, Nicolato R, Brito-Melo G, Correa H, Teixeira MM, Romano-Silva MA Increased serum levels of CCL11/eotaxin in schizophrenia. Prog. Neuropsychopharmacol. Biol. Psychiatry, 2007-11-23;32(3):710-4. 2007-11-23 [PMID: 18096286] (Human)
• Tudhope SJ, Catley MC, Fenwick PS, Russell RE, Rumsey WL, Newton R, Barnes PJ, Donnelly LE The role of IkappaB kinase 2, but not activation of NF-kappaB, in the release of CXCR3 ligands from IFN-gamma-stimulated human bronchial epithelial cells. J. Immunol., 2007-11-01;179(9):6237-45. 2007-11-01 [PMID: 17947699] (Human)
• Chang Y, Senechal S, de Nadai P, Chenivesse C, Gilet J, Vorng H, Legendre B, Tonnel AB, Wallaert B, Lassalle P, Tsicopoulos A Diesel exhaust exposure favors TH2 cell recruitment in nonatopic subjects by differentially regulating chemokine production. J. Allergy Clin. Immunol., 2006-06-21;118(2):354-60. 2006-06-21 [PMID: 16890758] (Human)
• Walker J, Tough DF Modification of TLR-induced activation of human dendritic cells by type I IFN: synergistic interaction with TLR4 but not TLR3 agonists. Eur. J. Immunol., 2006-07-01;36(7):1827-36. 2006-07-01 [PMID: 16783851] (Human)
• Curbishley SM, Eksteen B, Gladue RP, Lalor P, Adams DH CXCR 3 activation promotes lymphocyte transendothelial migration across human hepatic endothelium under fluid flow. Am. J. Pathol., 2005-09-01;167(3):887-99. 2005-09-01 [PMID: 16127166] (Human)
• Hauser IA, Spiegler S, Kiss E, Gauer S, Sichler O, Scheuermann EH, Ackermann H, Pfeilschifter JM, Geiger H, Grone HJ, Radeke HH Prediction of acute renal allograft rejection by urinary monokine induced by IFN-gamma (MIG). J. Am. Soc. Nephrol., 2005-04-27;16(6):1849-58. 2005-04-27 [PMID: 15857922] (Human)
• Kieseier BC, #N*´)2ZP, Tani M, y§/ÔcØÞ , Mahad D, Oka N, Ho T, Woodroofe N, Griffin JW, Toyka KV, Ransohoff RM, Hartung HP Chemokines and chemokine receptors in inflammatory demyelinating neuropathies: a central role for IP-10. 2002-04-01;125(0):823-34. 2002-04-01 [PMID: 11912115] (Human)

FAQs for CXCL9/MIG (DY392). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: CXCL9