Human C-Peptide Quantikine ELISA Kit

• Reactivity: Hu
• Applications: ELISA
• Conjugate: HRP

Human C-Peptide Quantikine ELISA Kit Summary

• Background: The Quantikine Human Insulin C-Peptide Immunoassay is a 2.5 hour solid-phase ELISA designed to measure human Insulin C-Peptide in cell culture supernates, serum, plasma, and urine. It contains synthetic human Insulin C-Peptide and has been shown to accurately quantitate the peptide. Results obtained using natural human Insulin C-Peptide showed linear curves that were parallel to the standard... curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring human Insulin C-Peptide.
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• Specificity: Natural and synthetic human Insulin C-Peptide.
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: INS

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human C-Peptide Quantikine ELISA Kit

• C-P
• C-Peptide
• IDDM2
• ILPR
• Insulin C-Peptide
• insulin
• IRDN
• MODY10
• Proinsulin C-Peptide
• proinsulin

Background

Insulin and the IGFs are members of the insulin family of molecules. IGF-I and II are structurally homologous to proinsulin, and can be thought of as taking the shape of an exaggerated, inverted letter G. Intrachain disulfide bonds link sections of the G. The single chain insulin propeptide consists of a 30 amino acid B chain (aa 2554), a C-peptide (aa 5589), and a 21 aa A chain (aa 90110). Removal of the C-peptide by proteolysis enables the formation of mature Insulin, a disulfidelinked heterodimer of the A and B chains. Circulating C-peptide levels are elevated in hyperinsulinism, obesity, and type II diabetes.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for C-Peptide (DICP00)(5)

Publications using DICP00

• Ghade, NS;Thappa, DK;Lona, J;Krishnan, AR;Sonar, SM; Comparative physicochemical and structural characterisation studies establish high biosimilarity between BGL-ASP and reference insulin aspart Scientific reports 2024-02-20 [PMID: 38378730] (Human)
• Hernandez, JD;Li, T;Ghannam, H;Rau, CM;Masuda, MY;Madura, JA;Jacobsen, EA;Filippis, E; Linking adipose tissue eosinophils, interleukin-4, and leptin in human obesity and insulin resistance JCI insight 2024-01-11 [PMID: 38206766] (Bioassay, Human)
• F Hoel, A Hoel, IK Pettersen, IG Rekeland, K Risa, K Alme, K Sørland, A Fosså, K Lien, I Herder, HL Thürmer, ME Gotaas, C Schäfer, RK Berge, K Sommerfelt, HP Marti, O Dahl, O Mella, Ø Fluge, KJ Tronstad A map of metabolic phenotypes in patients with myalgic encephalomyelitis/chronic fatigue syndrome JCI Insight, 2021-08-23;6(16):. 2021-08-23 [PMID: 34423789] (Human)
• KM Mohany, O Al Rugaie, O Al-Wutayd, A Al-Nafeesa Investigation of the levels of circulating miR-29a, miR-122, sestrin 2 and inflammatory markers in obese children with/without type 2 diabetes: a case control study BMC endocrine disorders, 2021-08-03;21(1):152. 2021-08-03 [PMID: 34344352] (Human)
• Z Ren, Z Yang, Y Lu, R Zhang, H Yang Anti?glycolipid disorder effect of epigallocatechin?3?gallate on high?fat diet and STZ?induced T2DM in mice Mol Med Rep, 2020-03-26;21(6):2475-2483. 2020-03-26 [PMID: 32236613] (Mouse)

Bioinformatics

• Gene Symbol: INS