The Quantikine Human ACE Immunoassay is a 4.5 hour solid phase ELISA designed to measure ACE in cell culture supernates, serum, plasma, and saliva. It contains NS0-expressed ectodomain of recombinant human sACE, and antibodies raised against the recombinant factor. Natural human ACE showed dose-response curves that were parallel to the standard curves obtained using the recombinant Quantikin...e kit standards, indicating that this kit can be used to determine relative levels of natural human ACE.
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Specificity
Natural and recombinant human ACE. In addition to soluble ACE, this kit recognizes membrane-bound forms from lysates of cultured cells and supernates.
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
carboxycathepsin
CD143 antigen
CD143
DCP
DCP1
DCP1angiotensin-converting enzyme
dipeptidyl carboxypeptidase 1
Dipeptidyl carboxypeptidase I
EC 3.2.1.-
EC 3.4.15.1
Kininase II
MGC26566
MVCD3
peptidase P
testicular ECA
Background
ACE and ACE-2, two cell surface proteases, are important regulators of the renin-angiotensin system (RAS), which plays a key role in maintaining blood pressure homeostasis and fluid salt balance in mammals. Because of its location and specificity, ACE plays additional roles in immunity, reproduction and neuropeptide regulation. ACE exists in two isoforms. Somatic ACE comprises two highly similar protease domains whereas germinal ACE comprises a single protease domain. ACE-2 consists of a single protease domain and is an essential regulator of heart and lung function. It is also a cellular receptor for the Spike protein of SARS cornonavirus that causes severe acute respiratory syndrome.
⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.
Publications for ACE/CD143 (DACE00)(5)
We have publications tested in 1 confirmed species: Human.