Human ACE DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human ACE DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: ACE

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human ACE DuoSet ELISA, 15 Plate

• ACE
• ACE1angiotensin converting enzyme, somatic isoform
• angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
• carboxycathepsin
• CD143 antigen
• CD143
• DCP
• DCP1
• DCP1angiotensin-converting enzyme
• dipeptidyl carboxypeptidase 1
• Dipeptidyl carboxypeptidase I
• EC 3.2.1.-
• EC 3.4.15.1
• Kininase II
• MGC26566
• MVCD3
• peptidase P
• testicular ECA

Background

ACE and ACE-2, two cell surface proteases, are important regulators of the renin-angiotensin system (RAS), which plays a key role in maintaining blood pressure homeostasis and fluid salt balance in mammals. Because of its location and specificity, ACE plays additional roles in immunity, reproduction and neuropeptide regulation. ACE exists in two isoforms. Somatic ACE comprises two highly similar protease domains whereas germinal ACE comprises a single protease domain. ACE-2 consists of a single protease domain and is an essential regulator of heart and lung function. It is also a cellular receptor for the Spike protein of SARS cornonavirus that causes severe acute respiratory syndrome.

Publications for ACE/CD143 (DY929)(10)

Publications using DY929

• Szabó, AÁ;Enyedi, EE;Pintér, TB;Mányiné, IS;Váradi, C;Bányai, E;Tóth, A;Papp, Z;Fagyas, M; Interference-Free Measurement of Urinary Angiotensin-Converting Enzyme (ACE) Activity: Diagnostic and Therapeutic Monitoring Implications Biomedicines 2025-10-16 [PMID: 41153809] (Human)
• Arthurs, AL;Dietrich, B;Knöfler, M;Lushington, CJ;Thomas, PQ;Adikusuma, F;Williamson, JM;Babikha, S;Damhuis, T;Jankovic-Karasoulos, T;Smith, MD;Pringle, KG;Roberts, CT; Genetically edited human placental organoids cast new light on the role of ACE2 Cell death & disease 2025-02-07 [PMID: 39920116] (Human)
• D Lee, JC Park, KS Jung, J Kim, JS Jang, S Kwon, MS Byun, D Yi, G Byeon, G Jung, YK Kim, DY Lee, SH Han, I Mook-Jung Application of QPLEXTM biomarkers in cognitively normal individuals across a broad age range and diverse regions with cerebral amyloid deposition Experimental & Molecular Medicine, 2022-01-20;0(0):. 2022-01-20 [PMID: 35058557] (Human)
• V Bánhegyi, A Enyedi, GÁ Fülöp, A Oláh, IM Siket, C Váradi, K Bottyán, M Lódi, A Csongrádi, AJ Umar, M Fagyas, D Czuriga, I Édes, M Pólos, B Merkely, Z Csanádi, Z Papp, G Szabó, T Radovits, I Takács, A Tóth Human Tissue Angiotensin Converting Enzyme (ACE) Activity Is Regulated by Genetic Polymorphisms, Posttranslational Modifications, Endogenous Inhibitors and Secretion in the Serum, Lungs and Heart Cells, 2021-07-06;10(7):. 2021-07-06 [PMID: 34359878] (Human)
• S Tejpal, N Sanghera, V Manoharan, J Planas-Igl, CC Bastie, J Klein-Seet Angiotensin Converting Enzyme (ACE): A Marker for Personalized Feedback on Dieting Nutrients, 2020-02-28;12(3):. 2020-02-28 [PMID: 32121233] (Human)
• Greulich T, Nell C, Koepke J, Fechtel J, Franke M, Schmeck B, Haid D, Apelt S, Filipovic S, Kenn K, Janciauskiene S, Vogelmeier C, Koczulla A Benefits of whole body vibration training in patients hospitalised for COPD exacerbations - a randomized clinical trial. BMC Pulm Med, 2014-04-11;14(0):60. 2014-04-11 [PMID: 24725369] (Human)
• Uri K, Fagyas M, Manyine Siket I, Kertesz A, Csanadi Z, Sandorfi G, Clemens M, Fedor R, Papp Z, Edes I, Toth A, Lizanecz E New perspectives in the renin-angiotensin-aldosterone system (RAAS) IV: circulating ACE2 as a biomarker of systolic dysfunction in human hypertension and heart failure. PLoS ONE, 2014-04-01;9(4):e87845. 2014-04-01 [PMID: 24691269] (Human)
• Fagyas M, Uri K, Siket I, Darago A, Boczan J, Banyai E, Edes I, Papp Z, Toth A New perspectives in the renin-angiotensin-aldosterone system (RAAS) III: endogenous inhibition of angiotensin converting enzyme (ACE) provides protection against cardiovascular diseases. PLoS ONE, 2014-04-01;9(4):e93719. 2014-04-01 [PMID: 24690767] (Human)
• Michaud A, Acharya K, Masuyer G, Quenech'du N, Gribouval O, Moriniere V, Gubler M, Corvol P Absence of cell surface expression of human ACE leads to perinatal death. Hum Mol Genet, 2013-10-24;23(6):1479-91. 2013-10-24 [PMID: 24163131] (Human)
• Miners JS, van Helmond Z, Kehoe PG, Love S Changes with age in the activities of beta-secretase and the Abeta-degrading enzymes neprilysin, insulin-degrading enzyme and angiotensin-converting enzyme. Brain Pathol., 2010-01-12;20(4):794-802. 2010-01-12 [PMID: 20175776] (Human)

FAQs for ACE/CD143 (DY929). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: ACE