Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
20mM Potassium Phosphate (pH 7.0) and 0.15M NaCl
Immunogen affinity purified
Manufactured by SDIX's proprietary Genomic Antibody Technology. GAT FAQs.
Alternate Names for Histone Deacetylase 4/HDAC4 Antibody
Histone Deacetylase 4
histone deacetylase A
Histone deacetylase 4 belongs to the histone deacetylase family type 2 which actively deacetylate the 4 core Histones. HDAC4 possesses two repression domains, one composed of the N-terminal 208 residues and the other consist of a deacetylase domain (1). The N-term will interact with the MADX-box of MEFC2 to negatively regulate expression. Additionally, the deacetylase activity of HDAC4 is subject to negative regulation by its N-terminal domain (2). HDAC4 is also implicated in the regulation of muscle differentiation. During muscle differentiation, HDC4 is shuttled between nuclear and cytoplasmic compartments. Phosphorylation by CAMK4 at S246, S467 and S632 can control HDAC4 subcellular localization (3-4).
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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