Immunohistochemistry: HIF-3 alpha Antibody [NBP1-03155] - Expression of hypoxia-inducible alpha subunits in normal and diseased lung tissue. There is no significant difference in HIF-3alpha expression in fibroblasts; ...read more
Western Blot: HIF-3 alpha Antibody [NBP1-03155] - (lane 1) 3T3 cell lysate and (lane 2) control 3T3 cell lysate.
Western Blot: HIF-3 alpha Antibody [NBP1-03155] - IPF derived fibroblasts have low expression of HIF-3alpha by hypermethylation. Western blot of HIF3alpha in IPF derived fibroblasts after treatment with 2 and 5uM of ...read more
Immunohistochemistry-Paraffin: HIF-3 alpha Antibody [NBP1-03155] - Staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody ...read more
Immunohistochemistry-Paraffin: HIF-3 alpha Antibody [NBP1-03155] - Staining of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. ...read more
Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
20mM Potassium Phosphate (pH 7.2) and 0.15M NaCl
0.01% Sodium Azide
Immunogen affinity purified
Alternate Names for HIF-3 alpha Antibody - BSA Free
Basic-helix-loop-helix-PAS protein MOP7
Class E basic helix-loop-helix protein 17
hypoxia inducible factor 3, alpha subunit
hypoxia-inducible factor 3-alpha
hypoxia-inducible factor-3 alpha 4
Inhibitory PAS domain protein
Member of PAS protein 7
MOP7PAS domain-containing protein 7
One of the most important factors in the cellular response to hypoxia is hypoxia-inducible factor (HIF), which transcriptionally activates genes encoding proteins that mediate adaptive responses to reduced oxygen availability. HIF is a heterodimer consisting of one of three subunits (HIF1-a, HIF2-a, or HIF3-a) bound to the aryl hydrocarbon receptor nuclear translocator (ARNT) that is also known as HIF1-b. HIF-a is a member of the basic helix-loop-helix (bHLH) superfamily, in which the HLH domain mediates subunit dimerization while the basic domain binds to DNA. HIF target genes play critical roles in metabolism, angiogenesis, cell proliferation, and cell survival; in fact, HIF3-a may be a marker for tumor growth and angiogenesis . Examples of HIF target genes include VEGF, glucose transporter 1 (GLUT1), and EPO. HIF binds to the hypoxia-responsive element, which contains the core recognition sequence 5'-TACGTG-3', in the cis-regulatory regions of hypoxia-inducible genes. Transcriptional activation by HIF is linked to its ability to recruit coactivator proteins such as CREB-binding protein (CBP), p300, steroid receptor coactivator-1, and translation initiation factor 2.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Sun Y, Liu X, Zeng X et al. Simvastatin-loaded sulfonated PEEK enhances angiogenesis and osteogenesis via miR-29cb2-mediated HIF-3 alpha downregulation Chemical Engineering Journal 2022-11-01 (IHC, Mouse)
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HIF Antibodies: Beyond HIF-1 alpha The hypoxia inducible factors are a family of heterodimeric transcription factors which are activated in response to lowered oxygen levels, or hypoxia. Although it may seem that HIF-1 alpha receives all the attention, other HIF antibodies, such as the... Read full blog post.
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