HAP1 Antibody (1B6) [FITC]

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications Flow, ICC/IF, IHC-Fr, IHC-P
Clone
1B6
Clonality
Monoclonal
Host
Mouse
Conjugate
FITC

HAP1 Antibody (1B6) [FITC] Summary

Immunogen
Fusion protein from rat HAP1. [UniProt# P54256]
Specificity
This is specific for isoforms A and B.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
HAP1
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
Application Notes
This HAP1 antibody is useful for Immunohistochemistry frozen and paraffin embedded sections, Western blot and Immunoprecipitation. In Western blot bands can be seen ~95 kDa for isoform A and ~110 kDa for isoform B. Immunocytochemistry/Immunofluorescence was reported in scientific literature.

Reactivity Notes

Human, mouse and rat.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for HAP1 Antibody (1B6) [FITC]

  • HAP2huntingtin-associated protein 2
  • hHLP1
  • HIP5
  • HLP1
  • HLPHAP-1
  • huntingtin-associated protein 1
  • Neuroan 1

Background

HAP1 (Huntingtin-associated protein 1) is a cytoplasmic protein that interacts with several proteins such as Huntingtin, p150Glued, KLC, TrkA, TATA-binding protein, proBDNF etc. and plays a key role in microtubule-dependent transport, vesicular trafficking, nerve growth, transcriptional regulation and signal transduction. HAP1 was originally discovered as huntingtin interacting neuronal protein (htt), the Huntington's disease protein, however, unlike htt (expressed ubiquitously throughout body), HAP1 is enriched in brain with abundant expression in the hypothalamus, amygdala, brain stem etc. HAP1 has been associated with microtubule-dependent transporters dynactin p150 and kinesin light chain, as well as with transport of various vesicular proteins or membrane receptors, including BDNF-containing vesicles, EGFR, type 1 inositol (1,4,5)-triphosphate receptor, gamma -aminobutyric acid, type A, receptor, and TRKA. Hap1 is also implicated in microtubule-dependent trafficking in neurons, vesicular transport, gene transcription regulation, membrane receptor trafficking and other functions such as calcium release and protein aggregation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

FAQs for HAP1 Antibody (NB110-74569F) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Biotin Labeled NB110-74569B
DyLight 405 Labeled NB110-74569V
DyLight 488 Labeled NB110-74569G
DyLight 550 Labeled NB110-74569R
DyLight 650 Labeled NB110-74569C
HRP Labeled NB110-74569H

Additional HAP1 Products

HAP1 NB110-74569F

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Bioinformatics

Gene Symbol HAP1