Glucosylceramidase/GBA Antibody

Images

 
Western Blot: Glucosylceramidase/GBA Antibody [NBP1-32271] - Sample(30 ug of whole cell lysate) A:Hep G2 7.5% SDS PAGE diluted at 1:500
Immunocytochemistry/ Immunofluorescence: Glucosylceramidase/GBA Antibody [NBP1-32271] - Paraffin-embedded human lung cancer, using GBA antibody at 1:100 dilution.
Immunohistochemistry-Paraffin: Glucosylceramidase/GBA Antibody [NBP1-32271] - paraffin-embedded human lung cancer, using GBA antibody at 1:100 dilution.

Product Details

Summary
Reactivity Hu, Ze, Rt, Po, Bv, PmSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.82 mg/ml

Order Details

Glucosylceramidase/GBA Antibody Summary

Immunogen
Recombinant protein encompassing a sequence within the C-terminus region of human GBA. The exact sequence is proprietary.
Localization
Lysosome membrane, Peripheral membrane protein, Lumenal side
Predicted Species
Rat (91%), Porcine (92%), Bovine (92%), Primate (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GBA
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:3000
  • Immunocytochemistry/Immunofluorescence 1:100-1:1000
  • Immunohistochemistry 1:100-1:1000
  • Immunohistochemistry-Paraffin 1:100-1:1000
Theoretical MW
60 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publication using
NBP1-32271 in the following applications:

Reactivity Notes

Zebrafish reactivity reported in scientific literature (PMID: 25326392). Chimpanzee (100%), Mouse (87%).

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
Preservative
0.01% Thimerosal
Concentration
0.82 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Glucosylceramidase/GBA Antibody

  • Acid beta-glucosidase
  • Alglucerase
  • beta-glucocerebrosidase
  • D-glucosyl-N-acylsphingosine glucohydrolase
  • EC 3.2.1.45
  • GBA
  • GBA1
  • GC
  • GCB
  • GLUC
  • glucosidase, beta, acid
  • glucosidase, beta; acid (includes glucosylceramidase)
  • Glucosylceramidase
  • Imiglucerase
  • lysosomal glucocerebrosidase

Background

This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants encoding the same protein.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Glucosylceramidase/GBA Antibody (NBP1-32271)(1)

We have publications tested in 2 confirmed species: Human, Zebrafish.

We have publications tested in 2 applications: ICC/IF, WB.


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ICC/IF
(1)
WB
(1)
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(1)
Zebrafish
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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol GBA
Entrez
Uniprot