Glucagon R/GCGR Antibody

Images

 
Immunohistochemistry-Paraffin: Glucagon R/GCGR Antibody [NLS4257] - Anti-GCGR / Glucagon Receptor antibody IHC of human Prostate, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after ...read more
Immunohistochemistry-Paraffin: Glucagon R/GCGR Antibody [NLS4257] - Analysis of anti-GCGR / Glucagon Receptor antibody with human adipocytes at 11 ug/ ml.
Immunohistochemistry-Paraffin: Glucagon R/GCGR Antibody [NLS4257] - Analysis of anti-GCGR / Glucagon Receptor antibody with human liver.

Product Details

Summary
Reactivity Hu, Bv, Ca, Eq, Ha, Mk, Pm, Mu, RtSpecies Glossary
Applications IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

Glucagon R/GCGR Antibody Summary

Immunogen
Synthetic 18 amino acid peptide from N-terminal extracellular domain of human Glucagon Receptor.
Localization
Plasma membrane
Specificity
Human Glucagon Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Predicted Species
Mouse (94%), Rat (94%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GCGR
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 15 - 20 ug/ml
Positive Control
Glucagon R/GCGR Lysate (NBL1-11006)

Reactivity Notes

Gorilla, Gibbon.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Glucagon R/GCGR Antibody

  • FLJ97182
  • GCGR
  • GGR
  • GLR
  • GL-R
  • Glucagon R
  • glucagon receptor
  • GlucagonR
  • MGC138246

Background

The Glucagon Receptor mediates the effects of glucagon in controlling glucose metabolism by initiating a cascade of events that regulate the amount of glucose released from the liver into the bloodstream. Glucagon generally functions as a counterregulatory hormone, opposing the actions of insulin, in maintaining the levels of blood glucose, particularly in patients with hypoglycemia. In patients with diabetes, excess glucagon secretion plays a primary role in the metabolic perturbations associated with diabetes, such as hyperglycemia. Glucagon knockout mice exhibit reduced glood glucose levels, improved glucose tolerance, elevated blood glucagon levels, and normal insulin levels. Despite a total absence of glucagon receptors, these animals maintained near-normal glycemia and normal lipidemia, in the presence of circulating glucagon concentrations that were elevated by two orders of magnitude. A missense mutation (Gly40Ser) in the glucagon receptor gene is associated with non-insulin-dependent diabetes mellitus. The glucagon receptor has been reported to be expressed in liver and adipose, but not in adrenal medulla. ESTs have been isolated from liver/spleen and kidney libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol GCGR
Entrez
Uniprot