GITR Ligand/TNFSF18 Antibody (109101)

Images

 
There are currently no images for GITR Ligand/TNFSF18 Antibody (MAB6941).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, B/N, CyTOF-ready
Clone
109101
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

GITR Ligand/TNFSF18 Antibody (109101) Summary

Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human GITR Ligand/TNFSF18
Glu52-Ser177
Accession # Q9UNG2
Specificity
Detects human GITR Ligand/TNFSF18 in direct ELISAs.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
TNFSF18
Purity
Protein A or G purified from ascites
Purity Statement
Protein A or G purified from ascites
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Blockade of Receptor-ligand Interaction
  • CyTOF-ready
  • Flow Cytometry 2.5 ug/10^6 cells
Publications
Read Publications using
MAB6941 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Purity
Protein A or G purified from ascites
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for GITR Ligand/TNFSF18 Antibody (109101)

  • Activation-inducible TNF-related ligand
  • AITRL
  • AITRLMGC138237
  • GITR Ligand
  • GITRL
  • GITRLglucocorticoid-induced TNFR-related protein ligand
  • Glucocorticoid-induced TNF-related ligand
  • hGITRLGITR ligand
  • TL6AITR ligand
  • TNFSF18
  • tumor necrosis factor (ligand) superfamily, member 18
  • tumor necrosis factor ligand superfamily member 18

Background

GITR (glucocorticoid-induced TNF receptor superfamily-related protein, also named AITR, activation-inducible TNF receptor superfamily-related protein) and GITR ligand (GITRL) are novel members of the TNF receptor (TNFR) and TNF superfamilies (SF) that have been designated TNFRSF18 and TNFSF18, respectively. Human GITRL cDNA encodes a 177 amino acid residues type II membrane protein. The carboxy-terminal extracellular domain shows sequence identity to TNF/TNFSF2 (21%), Fas ligand/TNFSF6 (21%), TRAIL/TNFSF10 (18%), and lymphotoxin alpha /TNFSF1 (18%). GITRL is constitutively expressed in human umbilical vein endothelial cells but is not expressed in resting or stimulated T cell lines, B cell lines or peripheral blood mononuclear cells. GITR, the receptor for GITRL, is expressed at low levels in peripheral blood T cells, bone marrow, thymus, spleen and lymph nodes. In contrast to mouse GITR, expression of human GITR is not induced by treatment with dexamethasone, but is up-regulated by antigen-receptor stimulation or by treatment with soluble anti-CD3 plus anti-CD28 or PMA plus ionomycin. Ligation of GITR has been found to induce nuclear factor (NF)-kappa B activation via TNF receptor-associated factor 2 and protect cells from TCR activation-induced cell death. It has been proposed that GITRL and GITR may modulate T lymphocyte functions in peripheral tissues.

  1. Nocentini, G. et al. (1997) Proc. Natl. Acad. Sci. USA 94:6216.
  2. Kwon, B. et al. (1999) J. Biol. Chem. 274:6056.
  3. Gurney, A.L. et al. (1999) Current Biology 9:215.
  4. Kwon, B. et al. (1999) Current Opinion in Immunology 11:340.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

MAB689
Species: Hu
Applications: Block, CyTOF-ready, ELISA(Cap), ELISA(Det), ELISA(Sta), Flow, WB
210-TA
Species: Hu
Applications: BA
NBP1-19371
Species: Ca, Hu, Mu, Po, Rb, Rt
Applications: Dual ISH-IHC, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, Simple Western, WB
DCDL40
Species: Hu
Applications: ELISA
DY417
Species: Mu
Applications: ELISA
DR2A00
Species: Hu
Applications: ELISA
H00003669-M01
Species: Hu
Applications: ELISA, ICC/IF, S-ELISA, WB
202-IL
Species: Hu
Applications: BA
NB100-56583
Species: Hu, Rb, Rt
Applications: Flow, IHC, IHC-P, KO, WB
NB100-39002
Species: Bv, Hu, Mu, Rt
Applications: Dual ISH-IHC, Flow, IB, ICC/IF, IHC, IHC-P, IP, Single-Cell Western, WB
MAB10541
Species: Hu
Applications: CyTOF-ready, Flow, ICC, Neut
285-IF
Species: Hu
Applications: BA
NBP1-49045
Species: Mu, Rt
Applications: Cell Depl, CyTOF-ready, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, InhibTFunc
AF2295
Species: Hu
Applications: CyTOF-ready, Flow, IHC, WB
462-TR/CF
Species: Mu
Applications: BA
MAB2738
Species: Hu
Applications: Flow
AF1028
Species: Hu
Applications: CyTOF-ready, Flow, IHC, WB
MAB7442
Species: Hu
Applications: B/N, WB
7268-CT
Species: Hu
Applications: BA
MAB6941
Species: Hu
Applications: Flow, B/N, CyTOF-ready

Publications for GITR Ligand/TNFSF18 Antibody (MAB6941)(6)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: ELISA Development, Flow Cytometry, Neutralization.


Filter By Application
ELISA Development
(1)
Flow Cytometry
(2)
Neutralization
(3)
All Applications
Filter By Species
Human
(6)
All Species
Showing Publications 1 - 6 of 6.
Publications using MAB6941 Applications Species
Schmiedel , Benjamin, Werner , Antje, Steinbacher , Julia, Nuebling , Tina, Buechele , Corina, Grosse-Hovest , Ludger, Salih , Helmut R Generation and preclinical characterization of a Fc-optimized GITR-Ig fusion protein for induction of NK cell reactivity against leukemia. Mol Ther, 2013;21(4):877-86. 2013 [PMID: 23380816] (Neutralization, Human) Neutralization Human
Baltz KM, Krusch M, Baessler T, Schmiedel BJ, Bringmann A, Brossart P, Salih HR Neutralization of tumor-derived soluble glucocorticoid-induced TNFR-related protein ligand increases NK cell anti-tumor reactivity. Blood, 2008;112(9):3735-43. 2008 [PMID: 18689545] (ELISA Development, Human) ELISA Development Human
Baltz KM, Krusch M, Bringmann A, Brossart P, Mayer F, Kloss M, Baessler T, Kumbier I, Peterfi A, Kupka S, Kroeber S, Menzel D, Radsak MP, Rammensee HG, Salih HR Cancer immunoediting by GITR (glucocorticoid-induced TNF-related protein) ligand in humans: NK cell/tumor cell interactions. FASEB J., 2007;21(10):2442-54. 2007 [PMID: 17360848] (Flow Cytometry, Human) Flow Cytometry Human
Cardona ID, Goleva E, Ou LS, Leung DY Staphylococcal enterotoxin B inhibits regulatory T cells by inducing glucocorticoid-induced TNF receptor-related protein ligand on monocytes. J. Allergy Clin. Immunol., 2006;117(3):688-95. 2006 [PMID: 16522472] (Neutralization, Human) Neutralization Human
Hanabuchi S, Watanabe N, Wang YH, Ito T, Shaw J, Cao W, Qin FX, Liu YJ Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL). Blood, 2006;107(9):3617-23. 2006 [PMID: 16397134] (Flow Cytometry, Human) Flow Cytometry Human
Godfrey WR, Spoden DJ, Ge YG, Baker SR, Liu B, Levine BL, June CH, Blazar BR, Porter SB Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function. Blood, 2005;105(2):750-8. 2005 [PMID: 15374887] (Neutralization, Human) Neutralization Human

Reviews for GITR Ligand/TNFSF18 Antibody (MAB6941) (0)

There are no reviews for GITR Ligand/TNFSF18 Antibody (MAB6941). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for GITR Ligand/TNFSF18 Antibody (MAB6941) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Additional GITR Ligand/TNFSF18 Products

Bioinformatics Tool for GITR Ligand/TNFSF18 Antibody (MAB6941)

Discover related pathways, diseases and genes to GITR Ligand/TNFSF18 Antibody (MAB6941). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for GITR Ligand/TNFSF18 Antibody (MAB6941)

Discover more about diseases related to GITR Ligand/TNFSF18 Antibody (MAB6941).
 

Pathways for GITR Ligand/TNFSF18 Antibody (MAB6941)

View related products by pathway.

PTMs for GITR Ligand/TNFSF18 Antibody (MAB6941)

Learn more about PTMs related to GITR Ligand/TNFSF18 Antibody (MAB6941).

Blogs on GITR Ligand/TNFSF18

There are no specific blogs for GITR Ligand/TNFSF18, but you can read our latest blog posts.
Omicron Variant Antibodies

Customers Who Bought This Also Bought

Contact Information

Download our Western Blot eHandbook

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our GITR Ligand/TNFSF18 Antibody (109101) and receive a gift card or discount.

Bioinformatics

Gene Symbol TNFSF18
Uniprot