GAT-1/SLC6A1 Antibody

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Western Blot: GAT-1/SLC6A1 Antibody [NB100-61097] - Rat hippocampal homogenate showing specific immunolabeling of the~ 67k GAT-1 protein.

Product Details

Summary
Reactivity Mu, Rt, MuSpecies Glossary
Applications WB, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

GAT-1/SLC6A1 Antibody Summary

Immunogen
Peptide corresponding to amino acid residues from the C-terminal region of rat GAT-1.
Specificity
Specific for the ~67k GAT-1 protein. Immunolabeling is blocked by the peptide used as antigen.
Predicted Species
Mouse (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SLC6A1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:1000
  • Immunohistochemistry 1:10-1:500

Reactivity Notes

It is anticipated that the antibody will also react with mouse tissue based on the fact that this species has 100% homology with the amino acid sequence used as antigen.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol
Preservative
No Preservative
Purity
Immunogen affinity purified

Alternate Names for GAT-1/SLC6A1 Antibody

  • GABA Transporter 1
  • GABATHG
  • GABATR
  • GABATRGAT-1
  • GABT1
  • GAT1
  • GAT-1
  • GAT1sodium- and chloride-dependent GABA transporter 1
  • SLC6A1
  • solute carrier family 6 (neurotransmitter transporter, GABA), member 1
  • Solute carrier family 6 member 1

Background

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl negative channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-1, the most abundant of the transporters, is found predominantly in neurons, but also in some specialized glia (Minelli et al., 1995). GAT-1 is thought to play a key role in epileptogenesis (Zhao et al. 2003).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol SLC6A1
Entrez
Uniprot