GABA-A R delta Antibody (S151-3)

Images

 
Western Blot: GABA-A R delta Antibody (S151-3) [NBP1-47616] - analysis of Rat Cell line lysates showing detection of GABA A Receptor protein using Mouse Anti-GABA A Receptor Monoclonal Antibody, Clone S151-3. Load: 15 ...read more
Immunocytochemistry/ Immunofluorescence: GABA-A R delta Antibody (S151-3) [NBP1-47616] - analysis using Mouse Anti-GABA A Receptor Monoclonal Antibody, Clone S151-3. Tissue: HaCaT cells. Species: Human. Fixation: Cold ...read more

Product Details

Summary
Reactivity RtSpecies Glossary
Applications WB, ICC/IF, IHC
Clone
S151-3
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1 mg/ml

GABA-A R delta Antibody (S151-3) Summary

Immunogen
Apparent mol. wt of 97kD, non-glycosylated version at 68kD. Other minor bands associated with hNIS at160 kDa, and degradation products at approx. 30 kDa, and approx. 15kDa.Synthetic peptide amino acids 15-34 of rat GABA-A-R-Delta
Localization
Cell Membrane, Cell Junction, Synapse, Postsynaptic Cell Membrane
Specificity
Detects approx 55kDa.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
GABRD
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1-10 ug/ml
  • Immunocytochemistry/Immunofluorescence 0.1-1.0 ug/ml
  • Immunohistochemistry 1:1000
Application Notes
2 ug/ml of GABA-A Receptor Delta Antibody was sufficient for detection of Delta1 GABA-A receptor in 10 ug of rat brain lysate by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary Antibody.

Reactivity Notes

Based on homology, It's predicted to detect Human and Mouse.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4) and 50% Glycerol
Preservative
0.09% Sodium Azide
Concentration
1 mg/ml
Purity
Protein G purified

Alternate Names for GABA-A R delta Antibody (S151-3)

  • EIG10
  • EJM7
  • GABA A R delta
  • GABA(A) receptor subunit delta
  • GABA-A receptor, delta polypeptide
  • GABAAR delta
  • GABAARd
  • GABRD
  • gamma-aminobutyric acid (GABA) A receptor, delta
  • gamma-aminobutyric acid receptor subunit delta
  • GEFSP5
  • MGC45284

Background

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA Receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six as, four bs and four gs, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for a- and b-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a g-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different a-subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Poltl et al., 2003). More recently there have been a number of studies demonstrating that the alpha-subunit of the receptor may affect subunit assembly (Korpi et al., 2002) and may also confer differential sensitivity to neurosteroids and to ethanol (Wallner et al., 2003; Wohlfarth et al., 2002).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NBP1-47616AF405
Alexa Fluor 488 Labeled NBP1-47616AF488
Alexa Fluor 647 Labeled NBP1-47616AF647
Alexa Fluor 700 Labeled NBP1-47616AF700
DyLight 350 Labeled NBP1-47616UV
DyLight 405 Labeled NBP1-47616V
DyLight 488 Labeled NBP1-47616G
DyLight 680 Labeled NBP1-47616FR
DyLight 755 Labeled NBP1-47616IR

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Bioinformatics

Gene Symbol GABRD
Entrez
Uniprot