Hu, Mu, RtApplications:
WB, IHC, IHC-Fr, IPHost:
Species: Hu, Mu, Rt, Bv
Applications: WB, IHC, IP
Host: Rabbit Polyclonal
WB, IHC, IHC-PHost:
Applications: RNAi, RNAi SP
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a channel associated with the GABAA Receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six as, four bs and four gs, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for a- and b-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a g-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different a-subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; P ltl et al., 2003). More recently there have been a number of studies demonstrating that the -subunit of the receptor may affect subunit assembly (Korpi et al., 2002) and may also confer differential sensitivity to neurosteroids and to ethanol (Wallner et al., 2003; Wohlfarth et al., 2002).
|Product By Gene ID
- gamma-aminobutyric acid receptor subunit delta
- GABA-A receptor, delta polypeptide
- GABA(A) receptor subunit delta
- gamma-aminobutyric acid (GABA) A receptor, delta
Bioinformatics Tool for GABA-A R delta
Discover related pathways, diseases and genes to GABA-A R delta. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.