Fetal Hemoglobin Antibody - BSA Free

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA
Clonality
Polyclonal
Host
Sheep
Conjugate
Unconjugated
Format
BSA Free
Concentration
1.0 mg/ml

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Fetal Hemoglobin Antibody - BSA Free Summary

Immunogen
Purified human hemoglobin F of fetal cord blood cell origin.
Specificity
By immunoelectrophoresis and ELISA this antibody reacts specifically with human hemoglobin F. No antibody was detected against hemoglobin A1, A2, S or human serum proteins.
Isotype
IgG
Clonality
Polyclonal
Host
Sheep
Gene
HBG1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA 1:1000 - 1:30000
  • Western Blot 1:1000-1:30000
Application Notes
ELISA for coating plates 1:100 - 1:500.
Control
HBG1/2 Overexpression Lysate
Publications
Read Publications using
NB110-41084 in the following applications:

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Fetal Hemoglobin Antibody - BSA Free

  • abnormal hemoglobin
  • A-gamma globin
  • gamma A hemoglobin
  • gamma globin
  • gamma-1-globin
  • gamma-2-globin
  • gamma-globin chain
  • G-gamma globin Paulinia
  • Hb F Agamma
  • hb F Ggamma
  • HBGA
  • HBGR
  • HBG-T1
  • HBG-T2
  • Hemoglobin gamma-1 chain
  • hemoglobin gamma-2 chain
  • Hemoglobin gamma-A chain
  • hemoglobin gamma-G chain
  • hemoglobin subunit gamma-1
  • hemoglobin subunit gamma-2
  • hemoglobin, gamma A
  • hemoglobin, gamma, regulator of
  • HSGGL1
  • methemoglobin
  • PRO2979

Background

The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Fetal Hemoglobin Antibody (NB110-41084)(6)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: ELISA, Flow.


Filter By Application
ELISA
(1)
Flow
(1)
All Applications
Filter By Species
Human
(2)
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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for Fetal Hemoglobin Antibody (NB110-41084). (Showing 1 - 2 of 2 FAQs).

  1. May I know if NB110-41084 is specific only to the gamma chain of Hemoglobin F and does not exhibit cross-reactivity with the Hemoglobin A chain? There are several anti-hemoglobin F antibodies on the market that exhibit cross-reactivity with the A chain; we are looking for an antibody that does NOT exhibit residual activity with the A chain.
    • For NB110-41084 please see Summary section of the datasheet. Specificity: "Hemoglobin F. No antibody was detected against hemoglobin A1, A2, S or human serum proteins." It appears that from testing, this antibody does not cross-react with Hemoglobin A1 or A2.
  2. Hello! I am looking at product NB110-41084, Fetal Hemoglobin antibody. Can you tell me if this cross reacts with Regular Hemoglobin typically found in adults?
    • No reactivity was detected against hemoglobin A1, A2, S or human serum proteins. So no, it will not crossreact with adult hemoglobin

Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Additional Fetal Hemoglobin Products

Array NB110-41084

Bioinformatics Tool for Fetal Hemoglobin Antibody (NB110-41084)

Discover related pathways, diseases and genes to Fetal Hemoglobin Antibody (NB110-41084). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for Fetal Hemoglobin Antibody (NB110-41084)

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Pathways for Fetal Hemoglobin Antibody (NB110-41084)

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Blogs on Fetal Hemoglobin

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Bioinformatics

Gene Symbol HBG1
Entrez
Uniprot