Fetal Hemoglobin Products

Description

The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'- epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.

Bioinformatics

Product By Gene ID

3047

Alternate Names

abnormal hemoglobin A-gamma globin gamma A hemoglobin gamma globin gamma-1-globin gamma-2-globin gamma-globin chain G-gamma globin Paulinia Hb F Agamma hb F Ggamma HBGA HBGR HBG-T1 HBG-T2 Hemoglobin gamma-1 chain hemoglobin gamma-2 chain Hemoglobin gamma-A chain hemoglobin gamma-G chain hemoglobin subunit gamma-1 hemoglobin subunit gamma-2 hemoglobin, gamma A hemoglobin, gamma, regulator of HSGGL1 methemoglobin PRO2979