Genetic Strategies: Knockout Validated: FCRN/FCGRT Antibody [NBP1-89128] - Western blot shows lysates of 293 human embryonic kidney parental cell line and FCGRT knockout (KO) 293 cell line. PVDF membrane was ...read more
Orthogonal Strategies: Western Blot: FCRN/FCGRT Antibody [NBP1-89128] - Analysis in human cell lines Caco-2 and HeLa using anti-FCGRT antibody. Corresponding FCGRT RNA-seq data are presented for the same cell ...read more
Orthogonal Strategies: Immunohistochemistry-Paraffin: FCRN/FCGRT Antibody [NBP1-89128] - Staining in human placenta and pancreas tissues. Corresponding FCGRT RNA-seq data are presented for the same tissues.
Western Blot: FCRN/FCGRT Antibody [NBP1-89128] - Analysis in human cell line THP-1.
Immunohistochemistry-Paraffin: FCRN/FCGRT Antibody [NBP1-89128] - Immunohistochemical staining of human liver shows moderate to strong cytoplasmic positivity in Kupffer cells.
Immunohistochemistry-Paraffin: FCRN/FCGRT Antibody [NBP1-89128] - Immunohistochemical staining of human cerebellum shows no positivity in neuronal cells as expected.
Immunohistochemistry-Paraffin: FCRN/FCGRT Antibody [NBP1-89128] - Staining of human placenta shows moderate to strong cytoplasmic positivity in Hofbauer cells.
Immunohistochemistry-Paraffin: FCRN/FCGRT Antibody [NBP1-89128] - Staining of human pancreas shows no positivity in exocrine glandular cells as expected.
Simple Western: FCRN/FCGRT Antibody [NBP1-89128] - Simple Western lane view shows a specific band for FCGRT in 0.2 mg/ml of h. Liver (left), HepG2 (middle) and THP-1 (right) lysate. This experiment was performed under ...read more
Simple Western: FCRN/FCGRT Antibody [NBP1-89128] - Electropherogram image(s) of corresponding Simple Western lane view. FCRN/FCGRT antibody was used at 1:20 dilution on h. Liver, HepG2, and THP-1 lysate(s).

Product Details

Reactivity HuSpecies Glossary
Applications WB, Simple Western, IHC, IHC-Fr, IHC-P, KO

Order Details

FCRN/FCGRT Antibody Summary

Specificity of human FCRN/FCGRT antibody verified on a Protein Array containing target protein plus 383 other non-specific proteins.
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Western Blot 0.4 ug/ml
  • Simple Western 1:20
  • Immunohistochemistry 1:5000 - 1:10000
  • Immunohistochemistry-Frozen 1:5000 - 1:10000
  • Immunohistochemistry-Paraffin 1:5000 - 1:10000
  • Knockout Validated
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. Use in Immunohistochemistry-Frozen reported in scientific literature (PMID 24278022).

In Simple Western only 10 - 15 uL of the recommended dilution is used per data point. Separated by Size-Wes, Sally Sue/Peggy Sue.

Theoretical MW
40 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Positive Control
FCRN/FCGRT Lysate (NBP2-65029)
Control Peptide
FCRN/FCGRT Protein (NBP1-89128PEP)
Read Publications using
NBP1-89128 in the following applications:

Reactivity Notes

Reactivity reported in scientific literature (PMID: 24260574)

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS (pH 7.2) and 40% Glycerol
0.02% Sodium Azide
Immunogen affinity purified

Alternate Names for FCRN/FCGRT Antibody

  • alpha-chain
  • Fc fragment of IgG, receptor, transporter, alpha
  • FcRn alpha chain
  • FCRN
  • FCRNimmunoglobulin receptor, intestinal, heavy chain
  • IgG Fc fragment receptor transporter alpha chain
  • IgG receptor FcRn large subunit p51
  • major histocompatibility complex class I-like Fc receptor
  • Neonatal Fc receptor
  • neonatal Fc-receptor for Ig


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for FCRN/FCGRT Antibody (NBP1-89128)(8)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 4 applications: IHC, IHC-Fr, IHC-P, WB.

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Showing Publications 1 - 8 of 8.
Publications using NBP1-89128 Applications Species
Zimmermann N, Thormann V, Hu B et al. Human isotype-dependent inhibitory antibody responses against Mycobacterium tuberculosis. EMBO Mol Med Nov 2 2016 [PMID: 27729388] (WB, Human) WB Human
Dalloneau E, Baroukh N, Mavridis K et al. Downregulation of the neonatal Fc receptor expression in non-small cell lung cancer tissue is associated with a poor prognosis. Oncotarget. Aug 23 2016 [PMID: 27384673] (WB, Human) WB Human
Morel A, Passot C, Arnoult C et al. The neonatal Fc receptor (FcRn) does not modulate hepatitis C virus neutralization J. Gen. Virol. 2015 Jan 22 [PMID: 25614590] (WB, Human) WB Human
Ko SY, Pegu A, Rudicell RS et al. Enhanced neonatal Fc receptor function improves protection against primate SHIV infection. Nature 2014 Oct 30 [PMID: 25119033]
Gupta S, Gach JS, Becerra JC et al. The Neonatal Fc Receptor (FcRn) Enhances Human Immunodeficiency Virus Type 1 (HIV-1) Transcytosis across Epithelial Cells. PLoS Pathog. 2013 Nov [PMID: 24311991] (WB, IHC-P, Human) WB, IHC-P Human
Baker K, Rath T, Flak MB et al. Neonatal Fc Receptor Expression in Dendritic Cells Mediates Protective Immunity Against Colorectal Cancer. Immunity 2013 Dec 12 [PMID: 24290911] (IHC, Human) IHC Human
Gupta S, Gach JS, Becerra JC et al. The Neonatal Fc receptor (FcRn) enhances human immunodeficiency virus type 1 (HIV-1) transcytosis across epithelial cells. PLoS Pathog 2013 Nov [PMID: 24278022] (WB, IHC-Fr, Human) WB, IHC-Fr Human
Seijsing J, Lindborg M, Lofblom J et al. Robust expression of the human neonatal Fc receptor in a truncated soluble form and as a full-length membrane-bound protein in fusion with eGFP. PLoS One 2013 [PMID: 24260574]

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Product General Protocols

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FAQs for FCRN/FCGRT Antibody (NBP1-89128). (Showing 1 - 1 of 1 FAQs).

  1. I use the anti-FcRn (Ref #NBP1-89128) and I was wondering if you have any clue about the nature of the higher slight band that we can see on the datasheet. Is it an isoform ?
    • The theoretical molecular weight of FCGRT is ~39.7kDa. We typically see this antibody run true to size, as although there is a signal peptide lost, there is a glycoslation site that will make up for the lost weight. In our image on our datasheet, lane 3 is the FCGRT protein co-expressed with a C- terminal myc-DDK tag, which is why we are seeing the faint signal ~3kDa above the protein of interest.

Positive Control Lysate(s)

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Diseases for FCRN/FCGRT Antibody (NBP1-89128)

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Blogs on FCRN/FCGRT.

FcRn - neonatal Fc receptor encoded by the FCGRT gene
Antibodies play an important role in the innate immune system by circulating in the bloodstream to fight off invading pathogens. IgG is the most prevalent of the five classes of antibodies (IgA, IgD, IgE, IgG, and IgM) and is the only one transmit...  Read full blog post.

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Gene Symbol FCGRT