FCRN/FCGRT Products

Description

The FCGRT gene encodes a 365 amino acid long, 39 kDA IgG receptor FcRn large subunit p51 protein that transfers immunoglobulin G antibodies across the placenta from mother to fetus, as well as functions to protect the antibody from degradation. FCGRT interacts with genes CA6, ELANE, AZGP1, B2M, and ALB. It has been linked to diseases such as: lupus, nephritis, leukemia, arthritis, immunodeficiency, epidermolysis bullosa acquisita, persistent fetal circulation syndrome, and pemphigus.

Bioinformatics

Entrez	14132 Mouse 2217 Human
Uniprot	AAH08734 Human NP_001129491 Human P55899 Human
Product By Gene ID	2217
Alternate Names	alpha-chain Fc fragment of IgG, receptor, transporter, alpha FcRn alpha chain FcRn FCRNimmunoglobulin receptor, intestinal, heavy chain IgG Fc fragment receptor transporter alpha chain IgG receptor FcRn large subunit p51 major histocompatibility complex class I-like Fc receptor Neonatal Fc receptor neonatal Fc-receptor for Ig

Related FCRN/FCGRT Blog Posts

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FcRn - neonatal Fc receptor encoded by the FCGRT gene Antibodies play an important role in the innate immune system by circulating in the bloodstream to fight off invading pathogens. IgG is the most prevalent of the five classes of antibodies (IgA, IgD, IgE, IgG, and IgM) and is the only one transmit...    Read more.

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