Fc gamma RIIA/CD32a Antibody (7.3) [DyLight 680]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, ICC/IF, ICC/IF
Clone
7.3
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 680

Order Details

Fc gamma RIIA/CD32a Antibody (7.3) [DyLight 680] Summary

Immunogen
K562 and FcgRII+L cells
Localization
Cell Surface
Specificity
This MAb reacts with a CD32 (FcgRII) epitope (cluster-4). It displays a stronger reaction with Daudi than with U937 cells. The epitope is located in domain 2 of FcgRIIa. Its Fab'2 fragments block immune complex binding. CD32 (Fc?RII) is a type 1 transmembrane glycoprotein that mediates several functions including phagocytosis, cytotoxicity, and immunomodulation as well as platelet aggregation. Three genes (A, B, and C) encode CD32 and at least 6 isoforms are generated via alternative mRNA splicing, i.e., IIa1, IIa2, IIb1, IIb2, IIb3 and IIc. Monocytes/macrophages, placental trophoblasts and endothelial cells express all isoforms. In addition, the IIb isoform is expressed by B cells, and the IIa isoform by platelets, granulocytes and, weakly, by B cells. NK cells and neutrophils express Isoform IIc. CD32 binds weakly to the Fc region of monomeric IgG but more strongly to IgG aggregates and immune complexes.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
FCGR2A
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunocytochemistry/Immunofluorescence
  • Immunofluorescence
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Fc gamma RIIA/CD32a Antibody (7.3) [DyLight 680]

  • CD32 antigen
  • CD32a
  • CD32MGC23887
  • CDw32fc-gamma-RIIa
  • Fc fragment of IgG, low affinity IIa, receptor (CD32)
  • Fc fragment of IgG, low affinity IIa, receptor for (CD32)
  • Fc gamma RIIA
  • FCG2
  • Fc-gamma RII-a
  • Fc-gamma-RIIa
  • FcGR
  • FCGR2
  • FCGR2A
  • FCGR2A1
  • FcgRIIA
  • FCRIIA
  • fcRII-a
  • IGFR2MGC30032
  • IgG Fc receptor II-a
  • Immunoglobulin G Fc receptor II
  • low affinity immunoglobulin gamma Fc region receptor II-a

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

ICC/IF Video Protocol

FAQs for Fc gamma RIIA/CD32a Antibody (NBP2-47830FR). (Showing 1 - 1 of 1 FAQ).

  1. Does any of your FCGR2A antibodies (19C10, 6D11, 13G9) cross react to FCGR2B?
    • For these antibodies, we have used the full-length protein FCGR2A (NP_067674) as the immunogen and we have not mapped the epitope that is detected with each Ab yet. I did an alignment of these two proteins and they are highly conserved thus it seems likely that there will be cross-reactivity.

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-47830AF350
Alexa Fluor 405 NBP2-47830AF405
Alexa Fluor 488 NBP2-47830AF488
Alexa Fluor 532 NBP2-47830AF532
Alexa Fluor 594 NBP2-47830AF594
Alexa Fluor 647 NBP2-47830AF647
Alexa Fluor 700 NBP2-47830AF700
Alexa Fluor 750 NBP2-47830AF750
Allophycocyanin NBP2-47830APC
Allophycocyanin/Cy7 NBP2-47830APCCY7
Biotin NBP2-47830B
Biotin NBP2-47830B
DyLight 350 NBP2-47830UV
DyLight 405 NBP2-47830V
DyLight 488 NBP2-47830G
DyLight 550 NBP2-47830R
DyLight 594 NBP2-47830DL594
DyLight 650 NBP2-47830C
DyLight 680 NBP2-47830FR
DyLight 755 NBP2-47830IR
FITC NBP2-47830F
Janelia Fluor 549 NBP2-47830JF549
Janelia Fluor 646 NBP2-47830JF646
PE NBP2-47830PE
PE/Atto594 NBP2-47830PEATT594
PE/Cy5.5 NBP2-47830PECY55
PE/Cy7 NBP2-47830PECY7
PerCP NBP2-47830PCP

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Bioinformatics Tool for Fc gamma RIIA/CD32a Antibody (NBP2-47830FR)

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Diseases for Fc gamma RIIA/CD32a Antibody (NBP2-47830FR)

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Bioinformatics

Gene Symbol FCGR2A