Fc gamma RIIA/CD32a Products

Description

The FCGR2A gene encodes a low affinity immunoglobulin gamma Fc region receptor II-a protein that in isoform 1 is 317 amino acids long at 35 kDA and at isoform 2 is 316 amino acids long at nearly 35 kDA. These proteins are found on the surface of many immune system response cells that act as a low affinity receptor through encouraging responses against pathogens and soluble antigens. Additionally, it functions to initiate phagocytosis of opsonized antigens. FCGR2A participates in Fc-GammaR pathway, osteoclast differentiation, signaling events controlled by PTP1B, and NFAT in immune response. It is known to interact with genes SYK, FYN, HCK, LGALS3, and PIK3R1. FCGR2A is linked to lupus, thrombocytopenia, b-cell lymphomas, otitis media, adult-onset still's disease, guillain-barre syndrome, asymptomatic dengue, severe acute respiratory syndrome.

Bioinformatics

Entrez	2212 Human
Uniprot	AAH20823 Human AAH20823.1 Human NM_021642 Human P12318 Human
Product By Gene ID	2212
Alternate Names	CD32 antigen CD32A CD32MGC23887 CDw32fc-gamma-RIIa Fc fragment of IgG, low affinity IIa, receptor (CD32) Fc fragment of IgG, low affinity IIa, receptor for (CD32) FCG2 Fc-gamma RII-a Fc-gamma-RIIa FcGR FCGR2 FCGR2A1 FcRII-a fcRII-a IGFR2MGC30032 IgG Fc receptor II-a Immunoglobulin G Fc receptor II low affinity immunoglobulin gamma Fc region receptor II-a