Fascin Antibody (FSCN1/417) [Biotin]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, IHC-P
Clone
FSCN1/417
Clonality
Monoclonal
Host
Mouse
Conjugate
Biotin

Order Details

Fascin Antibody (FSCN1/417) [Biotin] Summary

Immunogen
Full length recombinant human FSCN1 protein
Localization
Cytoplasmic
Marker
Dendritic Cell Marker
Specificity
Recognizes a protein of 55kDa, which is identified as fascin-1. Its actin binding ability is regulated by phosphorylation. Antibody to fascin-1 is a very sensitive marker for Reed-Sternberg cells and variants in nodular sclerosis, mixed cellularity, and lymphocyte depletion Hodgkin's disease. It is uniformly negative in lymphoid cells, plasma cells, and myeloid cells. Fascin-1 is also expressed in dendritic cells. This marker may be helpful to distinguish between Hodgkin lymphoma and non-Hodgkin lymphoma in difficult cases. Also, the lack of expression of fascin-1 in the neoplastic follicles in follicular lymphoma may be helpful in distinguishing these lymphomas from reactive follicular hyperplasia in which the number of follicular dendritic cells is normal or increased. Antibody to fascin-1 has been suggested as a prognostic marker in neuroendocrine neoplasms of the lung as well as in ovarian cancer. Fascin-1 expression may be induced by Epstein-Barr virus (EBV) infection of B cells with the possibility that viral induction of fascin in lymphoid or other cell types must also be considered in EBV-positive cases.
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Mouse
Gene
FSCN1
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Readout System
Control
Fascin Knockout HeLa Cell Lysate

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Fascin Antibody (FSCN1/417) [Biotin]

  • FAN1
  • FAN1,55 kDa actin-bundling protein
  • fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
  • Fascin
  • FLJ38511
  • FSCN1
  • HSN
  • p55actin bundling protein
  • singed (Drosophila)-like (sea urchin fascin homolog like)
  • singed-like (fascin homolog, sea urchin)
  • Singed-like Protein
  • SNL
  • SNLfascin

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Applications: WB, IHC, IHC-P

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for Fascin Antibody (NBP2-47801B) (0)

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Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-47801AF350
Alexa Fluor 405 NBP2-47801AF405
Alexa Fluor 488 NBP2-47801AF488
Alexa Fluor 532 NBP2-47801AF532
Alexa Fluor 594 NBP2-47801AF594
Alexa Fluor 647 NBP2-47801AF647
Alexa Fluor 700 NBP2-47801AF700
Alexa Fluor 750 NBP2-47801AF750
Allophycocyanin NBP2-47801APC
Allophycocyanin/Cy7 NBP2-47801APCCY7
Biotin NBP2-47801B
DyLight 350 NBP2-47801UV
DyLight 405 NBP2-47801V
DyLight 488 NBP2-47801G
DyLight 550 NBP2-47801R
DyLight 594 NBP2-47801DL594
DyLight 650 NBP2-47801C
DyLight 680 NBP2-47801FR
DyLight 755 NBP2-47801IR
FITC NBP2-47801F
HRP NBP2-47801H
Janelia Fluor 549 NBP2-47801JF549
Janelia Fluor 646 NBP2-47801JF646
PE NBP2-47801PE
PE/Atto594 NBP2-47801PEATT594
PE/Cy5.5 NBP2-47801PECY55
PE/Cy7 NBP2-47801PECY7
PerCP NBP2-47801PCP

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Contact Information

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Bioinformatics

Gene Symbol FSCN1