FAM3B Antibody

• Reactivity: Mu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: LYOPH

FAM3B Antibody Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse FAM3B
  Glu30-Arg235
  Accession # Q9D309
• Specificity: Detects mouse FAM3B in direct ELISAs and Western blots. In direct ELISAs, approximately 35% cross‑reactivity with recombinant human FAM3B is observed, approximately 5% cross-reactivity with recombinant mouse (rm) FAM3C is observed, and less than 1% cross-reactivity with rmFAM3D is observed.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: FAM3B
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot 0.1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for FAM3B Antibody

• 2-21
• C21orf11
• C21orf76PANDER
• chromosome 21 open reading frame 11
• Cytokine-like protein 2-21
• D21M16SJHU19e
• FAM3B
• family with sequence similarity 3, member B
• ORF9
• pancreatic derived factor
• Pancreatic-derived factor
• PANDER
• PRED44

Background

FAM3B, also known as Pancreatic-Derived factor (PANDER), is a secreted, monomeric, 23 kDa glycoprotein that belongs to a new family of four-helix bundle cytokines. It is highly expressed in pancreatic islet cells and reproductive epithelium. FAM3B has been shown to induce b-cell apoptosis and decrease insulin secretion. Two alternative N-termini, at Glu 30 and Ser 46, have been observed for mature FAM3B. The long version of mature mouse FAM3B shares 80%, 92%, and 75% amino acid sequence homology with the human, rat and canine mature FAM3B, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for FAM3B Antibody (AF2867)(2)

Publications using AF2867

• C Azevedo, G Teku, Y Pomeshchik, JF Reyes, M Chumarina, K Russ, E Savchenko, A Hammarberg, NJ Lamas, A Collin, GK Gouras, O Klementiev, M Hallbeck, R Taipa, M Vihinen, L Roybon Parkinson's disease and multiple system atrophy patient iPSC-derived oligodendrocytes exhibit alpha-synuclein-induced changes in maturation and immune reactive properties Proceedings of the National Academy of Sciences of the United States of America, 2022-03-16;119(12):e2111405119. 2022-03-16 [PMID: 35294277] (ICC, IHC, Human)
• Hou X, Wang O, Li Z, Mou H, Chen J, Deng B, Qian L, Liu X, Le Y Upregulation of pancreatic derived factor (FAM3B) expression in pancreatic beta-cells by MCP-1 (CCL2). Mol. Cell. Endocrinol., 2011-06-01;343(1):18-24. 2011-06-01 [PMID: 21664946] (Western Blot, Mouse)

Bioinformatics

• Gene Symbol: FAM3B
• Uniprot:
  • Q9D309()