FAIM3 Antibody (992338) [PerCP]

• Reactivity: Hu, Mu, Rt
• Applications: WB, Flow, CyTOF-ready
• Clone: 992338
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: PerCP

FAIM3 Antibody (992338) [PerCP] Summary

• Immunogen: Human embryonic kidney cell line HEK293-derived recombinant human Fc mu R/FAIM3
  Arg18-Gly251
  Accession # O60667
• Specificity: Detects human Fc mu R/FAIM3 in direct ELISAs. Detects human, mouse, and rat Fc mu R/FAIM3 in Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Flow Cytometry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Alternate Names for FAIM3 Antibody (992338) [PerCP]

• FAIM3
• Fas apoptotic inhibitory molecule 3
• Fc mu R
• Fc mu receptor
• FCMR
• immunoglobulin mu Fc receptor
• Regulator of Fas-induced apoptosis Toso
• Toso
• TOSOIgM Fc receptor

Background

FAIM3 may play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.