FAIM3 Antibody (992338) [Alexa Fluor™ Plus 680]

• Reactivity: Hu, Mu, Rt
• Clone: 992338
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 680

FAIM3 Antibody (992338) [Alexa Fluor™ Plus 680] Summary

• Specificity: Detects human Fc mu R/FAIM3 in direct ELISAs. Detects human, mouse, and rat Fc mu R/FAIM3 in Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for FAIM3 Antibody (992338) [Alexa Fluor™ Plus 680]

• FAIM3
• Fas apoptotic inhibitory molecule 3
• Fc mu R
• Fc mu receptor
• FCMR
• immunoglobulin mu Fc receptor
• Regulator of Fas-induced apoptosis Toso
• Toso
• TOSOIgM Fc receptor

Background

The human FAIM3 gene (also known as FCMR or TOSO), is a transmembrane sialoglycoprotein expressed mainly by lymphocytes. FAIM3 is a type I membrane protein with an intracellular C-terminal domain and an extracellular N-terminal domain (1). The extracellular domain has homology to the immunoglobulin variable region domains (1) and FAIM3 is identified as an Fc receptor for IgM (2, 3). The amino acid sequence of human FAIM3 is 58% and 55% identical to that of mouse and rat FAIM3, respectively. FAIM3 was shown to be over-expressed in chronic lymphocytic leukemia (CLL) (4) and associated with disease progression (5, 6). FAIM3 has also been linked to the homeostasis and activation of the innate immune system (7). Interestingly, there is growing evidence that neurodegenerative diseases are associated with the activation of the immune surveillance system. This system is responsible for controlling danger signals and responding accordingly to the magnitude and duration of the threat (8, 9).

1. Song, Y. et al (2005) J. Biol. Chem. 280(10):9618.
2. Shima H et al. (2010) Int. Immunol. 22:149.
3. Kubagawa H et al. (2009) J. Exp. Med. 206:2779.
4. Proto-Siqueira R et al. (2008) Blood, 112:394.
5. Pallasch, C et al. (2008) Blood, 112:4213.
6. Pallasch, C P et al (2009) Leukemia & lymphoma, 50:498.
7. Sigruener, A et al (2007) Biochemical and biophysical research communications, 359:723.
8. Richards R I et al (2016) Front. Neurosci. 10:193.
9. Planells-Ferrer L et al (2016) J Neurochem. 139:11.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.