FAIM3 Antibody (1E4) Summary
FAIM3 (AAH06401, 124 a.a. ~ 223 a.a) partial recombinant protein with GST tag.SEYEPSWEEQPMPETPKWFHLPYLFQMPAYASSSKFVTRVTT PAQRGKVPPVHHSSPTTQITHRPRVSRASSVAGDKPRTFLPS TTASKISALEGLLKPQ
FAIM3 - Fas apoptotic inhibitory molecule 3
Test in a species/application not listed above to receive a full credit towards a future purchase.
Packaging, Storage & Formulations
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
PBS (pH 7.4)
Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.
Antibody reactive against cell lysate and recombinant protein for western blot. It has also been used for ELISA. Use in FLOW cytometry reported in scientific literature ( PMID 25769920)
1 Review rated 3
H00009214-M01 in the following application:
Publications using H00009214-M01 in the following applications:
Other species not tested.
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for FAIM3 Antibody (1E4)
FAIM3 Fas apoptotic inhibitory molecule 3 Fc mu receptor FCMR immunoglobulin mu Fc receptor Regulator of Fas-induced apoptosis Toso Toso TOSOIgM Fc receptor Background
Apoptosis is an important process in maintaining normal tissue homeostasis and function. One of the major signals that regulate this process is mediated by the activation of the Fas receptor by its ligand. This leads to the formation of a Fas associated death domain (FADD), containing death inducing signalling complex, and the activation of caspase-8, which in turn activates downstream effector caspases, such as caspase-3 and -7 (Curting and Cotter, 2003). Recent experiments have shown that overexpression of FAIM3, a novel regulator of Fas induced apoptosis in lymphoid cells, Jurkat cells and in transgenic mice renders these cells resistant to Fas induced apoptosis but not to TRAIL induced apoptosis (Hitoshi et al, 1998; Song and Jacob, 2005). Furthermore, FAIM3 was found to associate with FADD, suggesting that it functions by disrupting the formation of the death inducing signalling complex. Despite its predicted molecular weight, FAIM3 often migrates at 60 kDa in SDS PAGE.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
for 1 year from date of receipt.
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Applications: WB, IHC, IHC-Fr, IHC-P, IP
Applications: WB, ELISA, Flow, S-ELISA
Publications for FAIM3 Antibody (H00009214-M01)(4)
We have publications tested in 1 confirmed species: Human.
We have publications tested in 1 application: FLOW.
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Publications using H00009214-M01
Anquetil F, Clavel C, Offer G et al. IgM and IgA Rheumatoid Factors Purified from Rheumatoid Arthritis Sera Boost the Fc Receptor- and Complement-Dependent Effector Functions of the Disease-Specific Anti-Citrullinated Protein Autoantibodies. J. Immunol. 2015 Mar 13 [PMID:25769920] (FLOW, Human) FLOW
Murakami Y, Narayanan S, Su S et al. Toso, a Functional IgM Receptor, Is Regulated by IL-2 in T and NK Cells. J Immunol. 2012 Jun 06 [PMID:22675200]
Li FJ, Kubagawa Y, McCollum MK et al. Enhanced levels of both membrane-bound and soluble forms of IgM Fc receptor in patients with chronic lymphocytic leukemia. Blood. 2011 Sep 09 [PMID:21908424]
Proto-Siqueira R, Panepucci RA, Careta FP et al. SAGE analysis demonstrates increased expression of TOSO contributing to Fas mediated resistance in CLL. Blood;112(2):394-7. 2008 Jul 15. [PMID:18434611]
FAIM3 Antibody (H00009214-M01) (1)
Average Rating: 3
(Based on 1 reviews)
We have 1 review tested in 1 species: Human.
We have 1 review tested in 1 application: ELISA.
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Reviews using H00009214-M01:
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Application ELISA Sample Tested PBMC CD14 negative fraction (Tcells, Bcells and NK cells) Species Human Comments "dilution used : 1/100 in PBS 1% BSA (30min on ice)1 wash Secondary antibody : goat anti mouse total IgG -FITC (Invitrogen) : 1/100 in PBS 1% BSA (30min on ice)2 washesData : FACSCAN, Beckman Coulter" Primary Anitbody
Dilution Ratio Incubation Dilution Buffer: PBS BSA 1%, Dilution Ratio: 1/100, Incubation Time: 30 minutes, Incubation Temp: 4 degrees Celsius Secondary Antibody
Secondary Description Secondary Ab: goat anti human mouse total IgG -FITC, Secondary Ab Dilution: 1/100 Secondary Manufacturer Cat# Invitrogen Details
Detection Notes Negative Control: isotype control, Wavelength: 488 ELISA Plate Details ELISA Detection Method: Facscan, ELISA Sample Concentration: 100000 cells Comments
Comments "dilution used : 1/100 in PBS 1% BSA (30min on ice)1 wash Secondary antibody : goat anti mouse total IgG -FITC (Invitrogen) : 1/100 in PBS 1% BSA (30min on ice)2 washesData : FACSCAN, Beckman Coulter"
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