Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
PBS (pH 7.4)
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for FAIM3 Antibody (1E4)
Fas apoptotic inhibitory molecule 3
Fc mu R
Fc mu receptor
immunoglobulin mu Fc receptor
Regulator of Fas-induced apoptosis Toso
TOSOIgM Fc receptor
Apoptosis is an important process in maintaining normal tissue homeostasis and function. One of the major signals that regulate this process is mediated by the activation of the Fas receptor by its ligand. This leads to the formation of a Fas associated death domain (FADD), containing death inducing signalling complex, and the activation of caspase-8, which in turn activates downstream effector caspases, such as caspase-3 and -7 (Curting and Cotter, 2003). Recent experiments have shown that overexpression of FAIM3, a novel regulator of Fas induced apoptosis in lymphoid cells, Jurkat cells and in transgenic mice renders these cells resistant to Fas induced apoptosis but not to TRAIL induced apoptosis (Hitoshi et al, 1998; Song and Jacob, 2005). Furthermore, FAIM3 was found to associate with FADD, suggesting that it functions by disrupting the formation of the death inducing signalling complex. Despite its predicted molecular weight, FAIM3 often migrates at 60 kDa in SDS PAGE.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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