Western Blot: ERO1L Antibody (4G3) [H00030001-M01] - ERO1L monoclonal antibody (M01), clone 4G3. Analysis of ERO1L expression in PC-12.
Immunohistochemistry-Paraffin: ERO1L Antibody (4G3) [H00030001-M01] - Analysis of monoclonal antibody to ERO1L on formalin-fixed paraffin-embedded human small Intestine. Antibody concentration 1.5 ug/ml.
Western Blot: ERO1L Antibody (4G3) [H00030001-M01] - ERO1L monoclonal antibody (M01), clone 4G3 Analysis of ERO1L expression in HeLa.
Western Blot: ERO1L Antibody (4G3) [H00030001-M01] - Analysis of ERO1L expression in transfected 293T cell line by ERO1L monoclonal antibody (M01), clone 4G3.Lane 1: ERO1L transfected lysate(54 KDa).Lane 2: ...read more
Sandwich ELISA: ERO1L Antibody (4G3) [H00030001-M01] - Detection limit for recombinant GST tagged ERO1L is approximately 3ng/ml as a capture antibody.
ERO1L (NP_055399, 90 a.a. ~ 178 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. DISQCGRRDCAVKPCQSDEVPDGIKSASYKYSEEANNLIEECEQAERLGAVDESLSEETQKAVLQWTKHDDSSDNFCEADDIQSPEAEY
ERO1L - ERO1-like (S. cerevisiae)
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Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
In 1x PBS, pH 7.4
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for ERO1L Antibody (4G3)
Endoplasmic oxidoreductin-1-like protein
ERO1 (S. cerevisiae)-like
ERO1-like (S. cerevisiae)
ERO1-like protein alpha
Perhaps the most distinctive feature of protein folding in the ER is the abundance of disulfide bonds that must form during maturation of proteins traveling along the secretory pathway. Formation of disulfide bonds is a redox reaction. Thus, to match the flux of disulfide bonds that exit from the ER by virtue of protein secretion, a flux of oxidizing equivalents into the ER is required. In eukaryotic cells, the essential protein relay supporting this flux, and hence disulfide bond formation, involves endoplasmic reticulum oxidoreductin 1 (Ero1) and protein disulfide isomerase (PDI). The temporal pattern of hypoxic ERO1-L alpha induction is very similar to that of genes triggered by the hypoxia inducible transcription factor (HIF-1) and is characteristically mimicked by cobalt and by deferoxamine, but is absent in cells with a defective aryl hydrocarbon receptor translocator (ARNT, HIF-1 alpha). We speculate from these findings that the expression of ERO1-L alpha is probably regulated via the HIF-pathway and thus belongs to the family of classic oxygen regulated genes.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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