Human reactivity reported by a customer review. Mouse reactivity reported in scientific literature (PMID: 19382908). Rat reactivity reported in scientific literature (PMID: 12767046).
Packaging, Storage & Formulations
Store at -20C. Avoid freeze-thaw cycles.
Whole serum diluted in PBS
0.05% Sodium Azide
This product is unpurified. The exact concentration of antibody is not quantifiable.
Alternate Names for IP3R1 Antibody
inositol 14,5-triphosphate receptor, type 1
inositol 14,5-trisphosphate receptor type 1
IP3 receptor isoform 1
spinocerebellar ataxia 15
spinocerebellar ataxia 16
Type 1 inositol 14,5-trisphosphate receptor
Type 1 InsP3 receptor
Inositol 1,4,5-trisphosphate (IP3) is a second messenger for many growth factors, hormones, and neuro-transmitters. Upon binding to the IP3 receptor (IP3R), IP3 triggers the release of intracellular, luminal calcium to the cytosol. Functional IP3R is a homo- or heterotetramer of ~240 kDa glycoprotein subunits, that is structurally reminiscent of members of the voltage-gated ion channel superfamily. IP3R protein is structurally and functionally related to one other important intracellular calcium-release channel, the ryanodine receptor. The similarity between the two receptors continues at the physiological level owing to a physical association each receptor can have with the immunophilin protein, FKBP12. Cytosolic calcium levels appear to be regulated by a feedback loop that starts with calcium activation of protein kinase C (PKC) and calcineurin, a protein phosphatase. Phosphorylation of the IP3R by PKC causes an increase in IP3-mediated calcium release. Concomitantly, the phosphatase activity of calcineurin is stimulated upon its association with the FKBP12-IP3R complex. Calcium release is reduced when the PKC target site on the IP3R is dephosphorylated by calcineurin resulting in calcium oscillations. Mammalian IP3R subunits are the product of three distinct genes that are widely expressed and differentially regulated. Type-I IP3R has been detected in heart, liver, kidney, ovary, and Purkinje neurons of the cerebellum. IP3R-II protein is found predominantly in the brain. Isoform III expression has been shown to occur in pancreatic islets, kidney and the gastrointestinal tract.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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