ERG Antibody

Images

 
Western Blot: ERG Antibody [NBP2-60655] - Total protein from Human THP-1, Jurkat and K562 cells was separated on a 7.5% gel by SDS-PAGE, transferred to PVDF membrane and blocked in 5% non-fat milk in TBST. The membrane ...read more
Immunocytochemistry/ Immunofluorescence: ERG Antibody [NBP2-60655] - HeLa cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X TBS + 0.5% Triton-X100. The cells were incubated ...read more
Immunohistochemistry-Paraffin: ERG Antibody [NBP2-60655] - IHC analysis of a formalin fixed paraffin embedded tissue section of the human kidney (NBP1-78269) using 1:100 dilution of ERG antibody. The signal was ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

ERG Antibody Summary

Immunogen
Partial recombinant human ERG protein (amino acids 13-114) [UniPro P11308]
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
ERG
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 - 2 ug/ml
  • Immunocytochemistry/Immunofluorescence 1:500
  • Immunohistochemistry 1:100 - 1:200
  • Immunohistochemistry-Paraffin 1:100-1:200
Control
ERG Lysate (NBP2-66206)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for ERG Antibody

  • transcriptional regulator ERG
  • 10ets-related
  • erg-3
  • p55
  • TMPRSS2-ERG prostate cancer specific
  • transcriptional regulator ERG
  • Transforming protein ERG
  • v-ets erythroblastosis virus E26 oncogene homolog (avian)
  • v-ets erythroblastosis virus E26 oncogene like (avian)
  • v-ets erythroblastosis virus E26 oncogene like

Background

Transcriptional regulator ERG (ETS-related gene) belongs to a family of transcription factors that shares a highly conserved DNA-binding domain (ETS domain) and differs from each other in other domains (such as absence or presence of the Pointed/SAM domain). ERG has been widely studied in human cancers; TMPRSS2-ERG fusion, which occurs on account of oncogenic translocations and interstitial deletions, is implicated in aggressive forms of prostate cancer. ERG is linked to normal processes such as mesoderm formation and is found to form functional complexes with Jun/Fos, with the resulting ternary complexes regulating expression of genes such as metalloprotease-1 (MMP-1) and MMP-3 (1). It may also participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of the local chromatin structure. Several isoforms exist, which range from the 35-kDa isoform 7 to the 55-kDa isoform ERG-3.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for ERG Antibody (NBP2-60655). (Showing 1 - 1 of 1 FAQ).

  1. I am looking for an antibody that can IP Erg protein and doesn't cross react with Fli protein.
    • I have spoken to the lab and they have informed me that actually that the antibody (catalog #NBP1-95857) is confirmed not to cross react with Fli1 protein so it should be a viable choice for you in your experiments on Erg.

Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol ERG