epithelial Sodium Channel alpha Antibody (2G4)

Images

 
Western Blot: epithelial Sodium Channel alpha Antibody (2G4) [NBP2-59382] - Analysis of Mouse Whole kidney homogenates showing detection of ~85kDa ENaC alpha protein using Mouse Anti-epithelial Sodium Channel alpha ...read more
Immunohistochemistry: epithelial Sodium Channel alpha Antibody (2G4) [NBP2-59382] - Immunohistochemistry analysis using Mouse Anti-epithelial Sodium Channel alpha Monoclonal Antibody, Clone 2G4 (NBP2-59382). Tissue: ...read more
Immunohistochemistry: epithelial Sodium Channel alpha Antibody (2G4) [NBP2-59382] - Immunohistochemistry analysis using Mouse Anti-epithelial Sodium Channel alpha Monoclonal Antibody, Clone 2G4 (NBP2-59382). Tissue: ...read more

Product Details

Summary
Reactivity Mu, RtSpecies Glossary
Applications WB, IHC
Clone
2G4
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

epithelial Sodium Channel alpha Antibody (2G4) Summary

Immunogen
Synthetic peptide from the N-terminal of Rat ENaC alpha (aa. 46-68)
Localization
Apical Cell Membrane
Specificity
Detects 85kDa.
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
SCNN1A
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:150
  • Western Blot 1:1000

Packaging, Storage & Formulations

Storage
Store at -20C.
Buffer
PBS (pH 7.4), 50% Glycerol
Preservative
0.09% Sodium Azide
Purity
Protein G purified

Alternate Names for epithelial Sodium Channel alpha Antibody (2G4)

  • alpha ENaC-2
  • Alpha-ENaC
  • Alpha-NaCH
  • amiloride-sensitive epithelial sodium channel alpha subunit
  • amiloride-sensitive sodium channel subunit alpha 2
  • amiloride-sensitive sodium channel subunit alpha
  • BESC2
  • ENaCA
  • ENaCalpha
  • Epithelial Na(+) channel subunit alpha
  • epithelial Sodium Channel alpha
  • FLJ21883
  • nasal epithelial sodium channel alpha subunit
  • Nonvoltage-gated sodium channel 1 subunit alpha
  • SCNEA
  • SCNN1
  • SCNN1A
  • sodium channel, nonvoltage-gated 1 alpha

Background

Epithelial Sodium Channel alpha (SCNN1A) is a subunit of the epithelial sodium channel (ENaC). ENac has high sodium selectivity, low conductance, and amiloride sensitivity. The functional channel of ENaC is composed of at least 3 subunits, alpha (SCNN1A), beta (SCNN1B), and gamma (SCNN1G). The 3 subunits show sequence similarities to one another, indicating descent from a common ancestral gene. Each encodes a protein containing 2 transmembrane domains, with intracellular amino and carboxyl termini. The alpha subunit supports sodium conductance when expressed alone; the beta and gamma subunits do not support sodium conductance by themselves, but greatly augment the channel activity when expressed in conjunction with the alpha subunit. ENaC in the kidney, lung and colon plays an essential role in trans- epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium re-uptake in the distal nephron of the kidney, thus regulating blood pressure. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddels syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol SCNN1A
Uniprot