epithelial Sodium Channel alpha Products

Antibodies
epithelial Sodium Channel alp ...
epithelial Sodium Channel alpha An...
NB100-74357
Species: Hu, Mu, Rt
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
epithelial Sodium Channel alp ...
epithelial Sodium Channel alpha An...
NBP2-16353
Species: Hu
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
epithelial Sodium Channel alp ...
epithelial Sodium Channel alpha An...
NBP1-84846
Species: Hu
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
epithelial Sodium Channel alp ...
epithelial Sodium Channel alpha Ov...
NBP2-10616
Applications: WB
Proteins
epithelial Sodium Channel alp ...
epithelial Sodium Channel alpha Re...
NBP1-84846PEP
Species: Hu
Applications: AC
RNAi
epithelial Sodium Channel alp ...
epithelial Sodium Channel alpha RNAi
H00006337-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Epithelial Sodium Channel alpha (SCNN1A) is a subunit of the epithelial sodium channel (ENaC). ENac has high sodium selectivity, low conductance, and amiloride sensitivity. The functional channel of ENaC is composed of at least 3 subunits, alpha (SCNN1A), beta (SCNN1B), and gamma (SCNN1G). The 3 subunits show sequence similarities to one another, indicating descent from a common ancestral gene. Each encodes a protein containing 2 transmembrane domains, with intracellular amino and carboxyl termini. The alpha subunit supports sodium conductance when expressed alone; the beta and gamma subunits do not support sodium conductance by themselves, but greatly augment the channel activity when expressed in conjunction with the alpha subunit. ENaC in the kidney, lung and colon plays an essential role in trans- epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium re-uptake in the distal nephron of the kidney, thus regulating blood pressure. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddel's syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Product By Gene ID 6337
Alternate Names
  • alpha ENaC-2
  • ENaCA
  • FLJ21883
  • Alpha-NaCH
  • ENaCa
  • Alpha-ENaC
  • BESC2
  • nasal epithelial sodium channel alpha subunit
  • SCNN1
  • amiloride-sensitive sodium channel subunit alpha 2
  • SCNEA
  • amiloride-sensitive sodium channel subunit alpha
  • Nonvoltage-gated sodium channel 1 subunit alpha
  • amiloride-sensitive epithelial sodium channel alpha subunit
  • Epithelial Na(+) channel subunit alpha
  • alpha-NaCH
  • ENaCalpha
  • alpha-ENaC
  • sodium channel, nonvoltage-gated 1 alpha

PTMs for epithelial Sodium Channel alpha

Learn more about PTMs related to epithelial Sodium Channel alpha.

Cleavage
Methylation
Phosphorylation
Demethylation
Ubiquitination

Bioinformatics Tool for epithelial Sodium Channel alpha

Discover related pathways, diseases and genes to epithelial Sodium Channel alpha. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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