epithelial Sodium Channel beta Antibody - BSA Free

Images

 
Western Blot: epithelial Sodium Channel beta Antibody [NBP3-18257] - Western blot analysis of Mouse mpkCCD cell lysates showing detection of epithelial Sodium Channel beta protein using Rabbit Anti-epithelial Sodium ...read more
Immunohistochemistry: epithelial Sodium Channel beta Antibody [NBP3-18257] - Immunohistochemistry analysis using Rabbit Anti-epithelial Sodium Channel beta Polyclonal Antibody (NBP3-18257). Tissue: kidney tissue. ...read more
Western Blot: epithelial Sodium Channel beta Antibody [NBP3-18257] - Western blot analysis of Rat kidney tissue lysates showing detection of epithelial Sodium Channel beta protein using Rabbit Anti-epithelial Sodium ...read more
Western Blot: epithelial Sodium Channel beta Antibody [NBP3-18257] - Western blot analysis of Mouse kidney cortex showing detection of epithelial Sodium Channel beta protein using Rabbit Anti-epithelial Sodium Channel ...read more

Product Details

Summary
Reactivity Hu, Mu, Rt, Ha, XpSpecies Glossary
Applications WB, ICC/IF, IHC, IP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Format
BSA Free
Concentration
1 mg/ml

Order Details

epithelial Sodium Channel beta Antibody - BSA Free Summary

Immunogen
Produced against the C-terminal tail (amino acids 617-638) of rat beta ENaC (antibody designation 3755-2)
Localization
Apical Cell Membrane
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SCNN1B
Purity
Protein A purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry 1:100
  • Immunoprecipitation
  • Western Blot 1:1000
Application Notes
Optimal dilutions for assays should be determined by the user.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS, 50% glycerol
Preservative
0.09% Sodium Azide
Concentration
1 mg/ml
Purity
Protein A purified

Alternate Names for epithelial Sodium Channel beta Antibody - BSA Free

  • amiloride-sensitive sodium channel subunit beta 1
  • amiloride-sensitive sodium channel subunit beta
  • BESC1
  • Beta-ENaC
  • Beta-NaCH
  • ENaCB
  • ENaCbeta
  • Epithelial Na(+) channel subunit beta
  • epithelial Sodium Channel beta
  • epithelial sodium channel beta-2 subunit
  • epithelial sodium channel beta-3 subunit
  • nasal epithelial sodium channel beta subunit
  • Nonvoltage-gated sodium channel 1 subunit beta
  • SCNEB
  • SCNN1B
  • sodium channel, nonvoltage-gated 1, beta

Background

SCNN1B is a subunit of the epithelial sodium channel, ENaC. ENac has high sodium selectivity, low conductance, and amiloride sensitivity. The functional channel of ENaC is composed of at least 3 subunits, alpha (SCNN1A), beta (SCNN1B), and gamma (SCNN1G). The 3 subunits show sequence similarities to one another, indicating descent from a common ancestral gene. Each encodes a protein containing 2 transmembrane domains, with intracellular amino and carboxyl termini. ENaC in the kidney, lung and colon plays an essential role in trans- epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium re-uptake in the distal nephron of the kidney, thus regulating blood pressure. Mutations in beta or gamma subunit of the epithelial sodium channel (ENaC) have been found to cause a hereditary form of human hypertension, Liddle syndrome.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol SCNN1B