Endorepellin/Perlecan/Heparan Sulfate Proteoglycan Antibody (A7L6) [DyLight 650]

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Product Details

Summary
Reactivity Hu, Mu, Po, Fi, MkSpecies Glossary
Applications Flow, IHC-P
Clone
A7L6
Clonality
Monoclonal
Host
Rat
Conjugate
DyLight 650

Endorepellin/Perlecan/Heparan Sulfate Proteoglycan Antibody (A7L6) [DyLight 650] Summary

Immunogen
Murine EHS laminin preparation
Localization
Basement membrane
Specificity
This MAb specifically precipitates heterogeneous material of high MW, identified as perlecan, a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. It does not cross-react with laminin, fibronectin, or dermatran sulfate proteoglycan. Because of perlecan s strategic location and ability to store and protect growth factors, it has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Rat
Gene
HSPG2
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody shomld be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Endorepellin/Perlecan/Heparan Sulfate Proteoglycan Antibody (A7L6) [DyLight 650]

  • basement membrane-specific heparan sulfate proteoglycan core protein
  • endorepellin (domain V region)
  • Endorepellin
  • heparan sulfate proteoglycan 2
  • HSPG
  • HSPG2
  • perlecan proteoglycan
  • Perlecan
  • PLCSchwartz-Jampel syndrome 1 (chondrodystrophic myotonia)
  • PRCAN
  • SJA
  • SJS
  • SJS1

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics Tool for Endorepellin/Perlecan/Heparan Sulfate Proteoglycan Antibody (NBP2-47695C)

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Diseases for Endorepellin/Perlecan/Heparan Sulfate Proteoglycan Antibody (NBP2-47695C)

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Pathways for Endorepellin/Perlecan/Heparan Sulfate Proteoglycan Antibody (NBP2-47695C)

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Bioinformatics

Gene Symbol HSPG2