A full-length human Interleukin-35-Fc fusion protein was used as immunogen for this antibody.
The human Interleukin-35 protein is a dimeric protein consisting of the human IL-12a/p35 subunit (NP_000873.2) and the human EBI3 (NP_005746) protein. This clone has been tested to be specific to the EBI3 subunit of the target protein. Clone 15K8D10 tests as being specific to the EBI3 subunit.
Protein G purified
< 0.06 EU/ug
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Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.1 ml PBS
0.05% Sodium Azide
Protein G purified
Alternate Names for EBI3 Antibody (15k8D10) - BSA Free
EBV-induced gene 3 protein
Epstein-Barr virus induced 3
Epstein-Barr virus induced gene 3
Epstein-Barr virus-induced gene 3 protein
IL-27 subunit beta
interleukin-27 subunit beta
IL-35 is a novel heterodimeric cytokine composed of the IL-12p35 subunit and the Epstein-Barr virus-induced gene 3 (EBI3) protein. As one of the IL-12 family members, IL-35 is known to play an essential role in immune regulation of the CD4+CD25+ regulatory T (Treg) cells, from which IL-35 is also specifically produced. IL-35 is able to expand CD4+CD25+ Treg cells whereas it can inhibit proliferation of CD4+CD25- effector T (Teff) cells and development of proinflammatory Th17 cells, suppressing inflammatory responses.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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