EBI3 Products

Description

EBI3 (Epstein-Barr virus-induced gene 3 protein) also known as IL-27B, is a secreted cytokine (1). It shares similar domain structure as IL-12B except there are only two fibronectin type -III domains instead of three. Through non-covalent interaction, EBI-3 binds to IL-12A (IL-12 p35), IL-23A (IL-23p19), or IL-27A (IL-27p28/IL-30) to form IL-35, IL-39, or IL-27, respectively (2-4). In addition to forming the heterodimeric cytokines, EBI-3 can also function on its own. Expression of EBI-3 is induced in neutrophils stimulated with TLR8 ligands, with no detectable increase in IL-35, IL-39 or IL-27 (5). EBI-3 also mediate IL-6 trans-signaling through receptor gp130 in B9 mouse plasmacytoma cells (6).

Bioinformatics

Uniprot	Q14213.2
Product By Gene ID	10148
Alternate Names	cytokine receptor EBI3 EBI-3 EBV-induced gene 3 protein Epstein-Barr virus induced 3 Epstein-Barr virus induced gene 3 Epstein-Barr virus-induced gene 3 protein IL-27 beta IL-27 subunit beta IL27B IL-27B IL35 EBI3 IL-35 EBI3 interleukin-27 subunit beta