Dynactin Subunit 1/DCTN1 Antibody

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Western Blot: Dynactin Subunit 1/DCTN1 Antibody [NBP1-71829] - Whole cell lysate from Jurkat (5, 15 and 50 mcg for WB), HeLa (H, 50 mcg; 1 mg for IP, 20% of IP loaded) and mouse NIH3T3 (M; 50 mcg) cells. Affinity ...read more

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, IP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml
 

Independent Antibodies

 

Biological Strategies

     

Order Details

Dynactin Subunit 1/DCTN1 Antibody Summary

Immunogen
The immunogen for this product maps to a region between residue 1228 to 1278 of human 150 kDa Dynein-Associated Polypeptide using the numbering given in entry NP_004073.2 (GeneID 1639).
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
DCTN1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:2000-1:10000
  • Immunoprecipitation 2 - 5 ug/mg lysate

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Tris-Citrate/Phosphate (pH 7.0 - 8.0)
Preservative
0.09% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Dynactin Subunit 1/DCTN1 Antibody

  • DAP-150
  • DCTN1
  • DP-150
  • dynactin 1 (p150, Glued (Drosophila) homolog)
  • Dynactin 1
  • Dynactin Subunit 1
  • glued homolog, Drosophila)
  • HMN7B
  • p135
  • p150 Glued (Drosophila) homolog
  • p150-glued

Background

This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein. Alternative splicing of this gene results in at least 2 functionally distinct isoforms: a ubiquitously expressed one and a brain-specific one. Based on its cytogenetic location, this gene is considered as a candidate gene for limb-girdle muscular dystrophy.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics Tool for Dynactin Subunit 1/DCTN1 Antibody (NBP1-71829)

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Diseases for Dynactin Subunit 1/DCTN1 Antibody (NBP1-71829)

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PTMs for Dynactin Subunit 1/DCTN1 Antibody (NBP1-71829)

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Bioinformatics

Gene Symbol DCTN1
Entrez
Uniprot