Dynactin Subunit 1/DCTN1 Products

Description

The DCTN1 gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein. Alternative splicing of this gene results in at least 2 functionally distinct isoforms: a ubiquitously expressed one and a brain-specific one. Based on its cytogenetic location, this gene is considered as a candidate gene for limb-girdle muscular dystrophy.

Bioinformatics

Entrez	1639 Human 13191 Mouse 29167 Rat
Uniprot	NP_004073 Human NP_004073.2 Human NM_004082 Human Q14203 Human
Product By Gene ID	1639
Alternate Names	p150 Glued (Drosophila) homolog p150-glued p135 dynactin subunit 1 dynactin 1 (p150, Glued (Drosophila) homolog) glued homolog, Drosophila) dynactin 1

Diseases related to Dynactin Subunit 1/DCTN1

Discover more about diseases related to Dynactin Subunit 1/DCTN1.

Amyotrophic Lateral Sclerosis
Sclerosis
Primary Lateral Sclerosis
Motor Neuron Disease
Nerve Degeneration
Dementia
Neurodegenerative Disorders
Secondary Parkinson Disease
Hypoventilation
Atrophy
Dystrophy
Depressive Disorder
Parkinson Disease
Frontotemporal Lobar Degeneration
Frontotemporal Dementia
Hereditary Motor And Sensory Neuropathies
Neuromuscular Diseases
Myopathy
Charcot-marie-tooth Disease

Pathways for Dynactin Subunit 1/DCTN1

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Transport
Pathogenesis
Localization
Cell Death
Vesicle Transport
Autophagic Cell Death
Mitosis
Skin Development
Oocyte Maturation
Muscle Atrophy
Mrna Splicing
Melanosome Transport
Cytoplasmic Transport
Rna Processing
Rna Interference

Research Areas for Dynactin Subunit 1/DCTN1

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Cell Cycle and Replication

PTMs for Dynactin Subunit 1/DCTN1

Learn more about PTMs related to Dynactin Subunit 1/DCTN1.

Phosphorylation
Cleavage

Bioinformatics Tool for Dynactin Subunit 1/DCTN1

Discover related pathways, diseases and genes to Dynactin Subunit 1/DCTN1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.