DRAM Antibody

Images

 
Western Blot: DRAM Antibody [NBP1-76759] - K562 cell lysate with DRAM antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
Immunocytochemistry/ Immunofluorescence: DRAM Antibody [NBP1-76759] - Mouse liver tissue with DRAM antibody at 20 ug/mL.
Immunohistochemistry-Paraffin: DRAM Antibody [NBP1-76759] - Mouse liver tissue with DRAM antibody at 2 ug/mL.
Immunocytochemistry/ Immunofluorescence: DRAM Antibody [NBP1-76759] - Human Liver tissue with DRAM antibody at 20 ug/mL.
Immunohistochemistry-Paraffin: DRAM Antibody [NBP1-76759] - Human liver tissue with DRAM antibody at 2.5 ug/ml.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

DRAM Antibody Summary

Immunogen
Antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human DRAM. The immunogen is located within amino acids 30 - 80 of DRAM.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
DRAM1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.5 - 2 ug/mL
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 20 ug/mL
  • Immunohistochemistry 2.5 ug/mL
  • Immunohistochemistry-Paraffin 2.5 ug/mL
Theoretical MW
30 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Control Peptide
DRAM Peptide (NBP1-76759PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for DRAM Antibody

  • Damage-regulated autophagy modulator
  • DNA damage-regulated autophagy modulator protein 1
  • DNA-damage regulated autophagy modulator 1
  • DRAMFLJ11259

Background

Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been suggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA, Bax, etc., and that the signaling pathways regulated by these genes together promote a full cell death response. By itself, DRAM cannot induce apoptosis, but the fact that it is inactivated in certain cancers highlights the importance of DRAM and suggests that autophagy may play a more important role in cancer than initially suspected. At least two different isoforms of DRAM are known to exist.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

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Diseases for DRAM Antibody (NBP1-76759)

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Bioinformatics

Gene Symbol DRAM1
Uniprot